Basic and Epidemiological study for the carcinogenic role of obesity and nutritional factors in breast and colon cancers
| Project/Area Number |
20500734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
NAKANO Shuji Nakamura Gakuen College, 栄養科学部, 教授 (40164248)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Hitomi 中村学園大学, 栄養科学部, 助教 (60412558)
ONO Misaki 中村学園大学, 栄養科学部, 助手 (10441726)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳癌 / 癌の一次予防 / 食事性因子 / 大豆イソフラボン / 肥満 / アディポカイン / シグナル伝達 / 症例対照研究 / 乳がん / クルクミン / ゲニステイン(大豆イソフラボン) / 乳がん細胞受容体状態 / 乳がん一次予防 / 食事調査 / 植物性脂質 / 健康と食生活 / 大腸がん |
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| Research Abstract |
Incidence of breast and colon cancer is increasing recently among Japanese women. As these cancers are considered to be obesity- and diet-linked diseases, we have investigated the association of breast carcinogenesis with visceral fat obesity and dietary factors through in vivo, in vitro, and epidemiological approaches. Model rats for visceral obesity did not produce any tumor 40 weeks after oral administration of ethylmethane sulphonate (EMS), while a control rats produced tumors in 2 rats out of 16 rats. Genistein (GEN), a phytochemical with weak estrogenic activity, did not suppress the incidence of EMS-induced hormone-dependent tumor in WKA rats fed on diets with low to high concentrations of GEN. A case-control study suggests that intakes of oil and plant lipids were associated with elevated risk for breast cancer, but not with Soybean intake in postmenopausal Japanese women. These results suggest that Soybean isoflavone may not reduce the risk of breast cancer for postmenopausal women.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Phase I/II study of a 3-week cycle of irinotecan and S-1 in patients with advanced colorectal cancer.2010
Author(s)
Kusaba H, Esaki T, Futami K, Tanaka S, Fujishima H, Mitsugi K, Sakai K, Ariyama H, Tanaka R, Kinugawa N, Ueki T, Mibu R, Baba E, Nakano S, Akashi K
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Journal Title
Cancer Sci. 101(12)
Pages: 2591-2595
Related Report
Peer Reviewed
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[Journal Article] Phase I study of the sequential administration of S-1 and Cisplatin for metastatic gastric cancer.2009
Author(s)
Baba E, Fujishima H, Kusaba H, Esaki T, Ariyama H, Kato K, Tanaka R, Mitsugi K, Shibata Y, Harada M, Nakano S
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Journal Title
Anticancer Res. 29(5)
Pages: 1727-1732
Related Report
Peer Reviewed
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[Journal Article] Schedule-dependent Synergistic Interaction between Gemcitabine and Oxaliplatin in Human Gallbladder Adenocarcinoma Cell Lines.2009
Author(s)
Makiyama A, Qin B, Uchino K, Shibata Y, Arita S, Isobe T, Hirano G, Kusaba H, Baba E, Akashi K, Nakano S
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Journal Title
Anti-Cancer Drugs, Anticancer Drugs. 20(2)
Pages: 123-130
Related Report
Peer Reviewed
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[Journal Article] Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation as Immunotherapy for Pancreatic Cancer.2009
Author(s)
Abe Y, Ito T, Baba E, Nagafuji K, Kawabe K, Choi I, Arita Y, Miyamoto T, Teshima T, Nakano S, Harada M
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Journal Title
Pancreas 38(7)
Pages: 815-819
NAID
Related Report
Peer Reviewed
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[Journal Article] A multicenter phase II study of biweekly paclitaxel and S-1 combination chemotherapy for unresectable or recurrent gastric cancer.2008
Author(s)
Nakajo A, Hokita S, Ishigami S, Miyazono F, Etoh T, Hamanoue M, Maenohara S, Iwashita T, Komatsu H, Satoh K, Aridome K, Morita S, Natsugoe S, Takiuchi H, Nakano S, Maehara Y, Sakamoto J, Aikou T ; Kyushu Taxol, TS-1, Study Group (KTT-SG)
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Journal Title
Cancer Chemother Pharmacol. 62
Pages: 1103-9
Related Report
Peer Reviewed
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