Does catechin from tea leaves improve diabetes-induced depression?
| Project/Area Number |
20500735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
YAMATO Takako Nakamura Gakuen College, 栄養科学部, 准教授 (70271434)
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| Co-Investigator(Kenkyū-buntansha) |
AOMINE Masahiro 中村学園大学, 栄養科学部, 教授 (60091261)
NISHIYAMA Atsuko 中村学園大学, 栄養科学部, 助手 (90461475)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 健康と食生活 / 糖尿病 / カテキン / ストレス / 一酸化窒素 / 食行動 / 酸化ストレス / 抗酸化力 / 神経伝達物質 / ラット / マイクロダイアリシス |
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| Research Abstract |
We studied the effects of catechins (EC, EGC, ECG, EGCG, and CAT) from tea leaves on hippocampal serotonin (5-HT) release in normal and diabetic rats,using in vivo microdialysis techniques. In addition, the effects of green tea beverage containing high concentration of catechins on oxidative stress and antioxidative activity in the serum of both rats were examined. Catechins significantly increased 5-HT release from hippocampus in both rats, more or less. Experiments of administration of beverage with high catechin in diabetic rat suggest that the level of the oxidative stress tended to decrease but the antioxidative activity increased.
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Report
(4 results)
Research Products
(41 results)
