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Anti-aging effect of diet therapy-Improvement of endothelial function by nutrition-

Research Project

Project/Area Number 20500736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionSeinan Jo Gakuin University

Principal Investigator

TAGAWA Tatsuya  Seinan Jo Gakuin University, 保健福祉学部, 教授 (50347142)

Co-Investigator(Renkei-kenkyūsha) YAGI Yasuo  西南女学院大学, 保健福祉学部, 教授 (80200476)
INAKI Mitsuharu  西南女学院大学, 保健福祉学部, 教授 (20261787)
UEDA Shinichiro  琉球大学, 大学院・医学研究科, 教授 (80285105)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords血管内皮機能 / メタボリックシンドローム / 栄養学的介入 / 動脈硬化予防 / アンチエイジング
Research Abstract

The aim of the present study was to examine whether long-term treatment of L-arginine also improves endothelial function in human forearms. Forearm blood flow (FBF) was measured by strain gauge plethysmography in nine healthy women, before and four weeks after oral treatment with L-arginine (2.5 g/day). FBF was measured during reactive hyperemia (RH). The long-term treatment with L-arginine significantly improved total reactive hyperemic flow (flow debt repayment) (P < 0.01). Our results suggest that L-arginine treatment may increase NO production in endothelium during reactive hyperemia in human forearm vessel.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (17 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Free fatty acid causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells2010

    • Author(s)
      Azekoshi Y, Yasu T, Watanabe S, Tagawa T, Abe S, Yamakawa K, Uehara Y, Momomura S, Urata H, Ueda S
    • Journal Title

      Hypertension Vol.56

      Pages: 136-142

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルギニンの経口投与によるヒト血管内皮機能の改善効果に関する研究2010

    • Author(s)
      田川辰也、天本理恵、石本祐子、甲斐さや香、柏由佳、北山佳奈
    • Journal Title

      西南女学院大学紀要 Vol.14

      Pages: 69-75

    • NAID

      110008705270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルギニンの経口投与によるヒト血管内皮機能の改善効果に関する研究2010

    • Author(s)
      田川辰也、天本理恵、石本祐子、甲斐さや香、柏由佳、北山佳奈
    • Journal Title

      西南女学院大学紀要

      Volume: 14 Pages: 69-75

    • NAID

      110008705270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free fatty acid causes leukocyte activation and resultant endothelialdysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells.2010

    • Author(s)
      Azekoshi Y, Yasu T, Watanabe S, Tagawa T, Abe S, Yamakawa K, Uehara Y, Momomura S, Urata H, Ueda S
    • Journal Title

      Hypertension

      Volume: 56 Pages: 136-142

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルギニンの経口投与によるヒト血管内皮機能の改善効果に関する研究2010

    • Author(s)
      田川辰也、天本理恵、石本祐子、柏由佳、甲斐さや香、北山佳奈
    • Journal Title

      西南女学院大学紀要 14

      Pages: 69-75

    • NAID

      110008705270

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FFA causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells.2010

    • Author(s)
      Azekoshi Y, Yasu T, Watanabe S, Tagawa T, Abe S, Yamakawa K, Uehara Y, Momomura S, Urata H, Ueda S
    • Journal Title

      Hypertension (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels2008

    • Author(s)
      Minami H, Yasu T, Tagawa T, Yamakawa K, Ueda S
    • Journal Title

      Eur J Clin Parmacol Vol.64

      Pages: 859-862

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparability and reproducibility of the carotid-femoral pulse wave velocity measurements using a multi-element carotid tonometry sensor2008

    • Author(s)
      Ueda I, Tagawa T, Watanabe S, Yamakawa K, Yasu T, Ueda S
    • Journal Title

      J Hum Hypertens Vol.22

      Pages: 699-703

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparability and reproducibility of the carotid-femoral pulse wave velocity measurements using a multi-element carotid tonometry sensor.2008

    • Author(s)
      Ueda I, Tagawa T, Watanabe S, Yamakawa K, Yasu T, Ueda S
    • Journal Title

      J Hum Hypertens 22

      Pages: 699-703

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels.2008

    • Author(s)
      Minami H, Yasu T, Tagawa T, Yamakawa K, Ueda S
    • Journal Title

      Eur J Clin Parmacol 64

      Pages: 859-862

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食生活・アルコールに関する保健指導2010

    • Author(s)
      田川辰也
    • Organizer
      福岡県医師会特定健診・特定保健指導フォローアップ研修会
    • Place of Presentation
      福岡市(福岡県医師会館)
    • Year and Date
      2010-08-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 食生活・アルコールに関する保健指導2010

    • Author(s)
      田川辰也
    • Organizer
      福岡県医師会特定健診・特定保健指導フォローアップ研修会
    • Place of Presentation
      福岡県医師会館(福岡市)
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] メタボリックシンドロームの血管内皮機能障害の問題点と対策2010

    • Author(s)
      田川辰也
    • Organizer
      福岡県研究教育栄養士協議会研究会
    • Place of Presentation
      福岡市(中村学園大学)
    • Year and Date
      2010-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] メタボリックシンドロームの血管内皮機能障害の問題点と対策2010

    • Author(s)
      田川辰也
    • Organizer
      福岡県研究教育栄養士協議会研修会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生活習慣病と栄養~メタボリックシンドロームを中心に~2009

    • Author(s)
      田川辰也
    • Organizer
      食育のための協力栄養士養成研修会
    • Place of Presentation
      北九州市(総合保健福祉センター)
    • Year and Date
      2009-08-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 生活習慣病と栄養 ~メタボリックシンドロームを中心に~2009

    • Author(s)
      田川辰也
    • Organizer
      食育のための協力栄養士養成研修会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-08-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 食生活・アルコールに関する保健指導2009

    • Author(s)
      田川辰也
    • Organizer
      福岡県医師会特定健診・特定保健指導フォローアップ研修会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放置するとこわいメタボリックシンドローム-食事と運動で脱メタボ-2009

    • Author(s)
      田川辰也
    • Organizer
      第19回市民健康セミナー
    • Place of Presentation
      北九州市(私立商工貿易会館)
    • Year and Date
      2009-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 放置するとこわいメクボリックシンドローム-食事と運動で脱メタボ-2009

    • Author(s)
      田川辰也
    • Organizer
      第19回市民健康セミナー
    • Place of Presentation
      北九州市
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脱メタボリックシンドロームで動脈硬化予防-栄養と運動の役割-2009

    • Author(s)
      田川辰也
    • Organizer
      食と健康を学ぼう2009-合同公演会・健診-
    • Place of Presentation
      北九州市(小倉医師会館)
    • Year and Date
      2009-01-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 脱メタボリックシンドロームで動脈硬化予防-栄養と運働の役割-2009

    • Author(s)
      田川辰也
    • Organizer
      食と健康を学ぼう2009-合同公演会・健診-
    • Place of Presentation
      北九州市
    • Year and Date
      2009-01-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] メタボリックシンドロームと血管内皮機能障害2008

    • Author(s)
      田川辰也
    • Organizer
      心血管疾患アップ・トゥ・デート討論会
    • Place of Presentation
      福岡市(ミタカホール)
    • Year and Date
      2008-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] メタボリックシンドロームと血管内皮機能障害2008

    • Author(s)
      田川辰也
    • Organizer
      心血管疾患アップ・トゥ・デート討論会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 栄養・食生活の基礎知識及び今日的課題と対策2008

    • Author(s)
      田川辰也
    • Organizer
      福岡県医師会食生活改善指導担当者研修会
    • Place of Presentation
      福岡市(福岡県医師会館)
    • Year and Date
      2008-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 栄養・食生活の基礎知識及び今日的課題と対策2008

    • Author(s)
      田川辰也
    • Organizer
      福岡県医師会食生活改善指導担当者研修会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-10-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] The relationship between the sensitivity to Umami and Eating Habits in young female2008

    • Author(s)
      Toyama K, Tagawa T, Sakamaki R, Amamoto R
    • Organizer
      15^<th> International Congress of Dietetics
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Related Report
      2010 Final Research Report
  • [Presentation] The relationship between the sensitivity to Umami and Eating Habits in young female.2008

    • Author(s)
      Toyama K, Tagawa T, Sakamaki R, Amamoto R
    • Organizer
      15^<th> International Congress of Dietetics
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2008 Annual Research Report
  • [Book] 人体の構造と機能および疾病の成り立ち疾病の成因・病態・診断・治療(第2版)2010

    • Author(s)
      竹中優、田川辰也、他
    • Total Pages
      330
    • Publisher
      医歯薬出版
    • Related Report
      2010 Final Research Report
  • [Book] 人体の構造と機能および疾病の成り立ち 疾病の成因・病態・診断・治療2010

    • Author(s)
      竹中優, 田川辰也, 他
    • Total Pages
      330
    • Publisher
      医歯薬出版
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.seinan-jo.ac.jp/univers/c00195.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.seinan-jo.ac.jp/univers/c00195.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.seinan-jo.ac.jp/univers/c00195.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.seinan-jo.ac.jp/univers/c00195.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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