Roles of odorant receptor signaling in axonal projection of olfactory sensory neurons

• Project/Area Number: 20509002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: IMAI Takeshi The University of Tokyo, 大学院・理学系研究科, 客員共同研究員 (70509851)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: シグナル伝達 / 発生・再生 / 神経科学 / 脳・神経

Research Abstract

In this study, we found that odorant receptors control axonal projection of olfactory sensory neurons via Gs and Golf, each controlling distinct phase of axon guidance. We also analyzed the pre-target axon sorting for olfactory map formation in mice, and found that pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.

Research Products

• [Journal Article] Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes respond differently to phenyl ethers. (2011)
  • Author(s): Tsuboi A, Imai T, Kato HK, Matsumoto H, Igarashi KM, Suzuki M, Mori K, Sakano H
  • Journal Title: Eur J Neurosci. 33(2) Pages: 205-13
  • Peer Reviewed
• [Journal Article] Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes respond differently to phenyl ethers. (2011)
  • Author(s): Tsuboi A*, Imai T*, Kato HK, Matsumoto H, Igarashi KM, Suzuki M, Mori K, Sakano H.(*equally contributed)
  • Journal Title: Eur J Neurosci. Volume: 33 Pages: 205-213
  • Peer Reviewed
• [Journal Article] Topographic mapping--the olfactory system. (2010)
  • Author(s): Imai T, Sakano H, Vosshall LB
  • Journal Title: Cold Spring Harb Perspect Biol. 2(8)(Review)
  • Peer Reviewed
• [Journal Article] Topographic mapping--the olfactory system. (2010)
  • Author(s): Imai T, Sakano H, Vosshall LB.
  • Journal Title: Cold Spring Harb Perspect Biol. Volume: 2
  • Peer Reviewed
• [Journal Article] Pre-target axon sorting establishes the neural map topography. (2009)
  • Author(s): Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H
  • Journal Title: Science. 325(5940) Pages: 585-90
  • NAID: 40016977752
  • Peer Reviewed
• [Journal Article] Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System. (2009)
  • Author(s): Imai T, Sakano H
  • Journal Title: Results Probl Cell Differ. 47(Review) Pages: 57-75
  • Peer Reviewed
• [Journal Article] Pre-target axon sorting establishes the neural map topography (2009)
  • Author(s): Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H
  • Journal Title: Science 325 Pages: 585-590
  • NAID: 40016977752
  • Peer Reviewed
• [Journal Article] Odorant receptor-mediated signaling in the mouse. (2008)
  • Author(s): Imai T, Sakano H
  • Journal Title: Curr Opin Neurobiol. 18(Review) Pages: 251-260
  • Peer Reviewed
• [Journal Article] Interhemispheric olfactory circuit and the memory beyond. (2008)
  • Author(s): Imai T, Sakano H
  • Journal Title: Neuron. 58(4)(Preview) Pages: 465-7
• [Journal Article] Interhemispheric olfactory circuit and the memory beyond (2008)
  • Author(s): Imai T, Sakano H
  • Journal Title: Neuron 58(4) Pages: 465-467
• [Journal Article] Odorant receptor-mediated signaling in the mouse (2008)
  • Author(s): Imai T, Sakano H
  • Journal Title: Curr Opin Neurobiol 18(3) Pages: 251-260
  • Peer Reviewed
• [Journal Article] Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System (2008)
  • Author(s): Imai T, Sakano H
  • Journal Title: Results Probl Cell Differ (Epub)
  • Peer Reviewed
• [Journal Article] Axon-axon interactions in the neuronal circuit assembly--lessons from olfactory map formation.
  • Author(s): Imai T, Sakano H
  • Journal Title: Eur J Neurosci. (in press, 掲載確定)
  • Peer Reviewed
• [Presentation] 嗅覚受容体依存的な軸索投射を制御するcAMPシグナル (2010)
  • Author(s): 今井猛、鈴木悟、坂野仁
  • Organizer: 第33回日本神経科学大会/第53回日本神経化学会大会/第20回日本神経回路学会大会合同大会Neuro2010 A distinct cAMP signaling pathway mediates the odorant receptor-instructed coarse targeting of axons
  • Place of Presentation: 神戸、兵庫県(口頭発表)
  • Year and Date: 2010-09-02
• [Presentation] A distinct cAMP signaling pathway mediates the odorant receptor-instructed coarse targeting of axons (2010)
  • Author(s): 今井猛、鈴木悟、坂野仁
  • Organizer: 第33回日本神経科学大会/第53回日本神経化学会大会/第20回日本神経回路学会大会合同大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-02
• [Presentation] Olfactory map formation directed by the odorant receptor-derived cAMP signals (2010)
  • Author(s): Takeshi Imai
  • Organizer: The 20th Hot Spring Harbor Symposium and joint with the 6th Global COE International Symposium New Horizons for Modern Science : Biology and Medicine at the Crossroads
  • Place of Presentation: The Luigans Spa & Resort(福岡県) 招待講演
  • Year and Date: 2010-08-20
• [Presentation] Pre-target axon sorting establishes the neural map topography (2009)
  • Author(s): 今井猛
  • Organizer: 神経組織の成長・再生・移植研究会 第24回学術集会「神経回路の可塑性と再生戦略」シンポジウム
  • Place of Presentation: 伊香保、群馬県
  • Year and Date: 2009-06-21
• [Presentation] Pre-target axon sorting for the topographic map.formation in the mouse olfactory system. (2009)
  • Author(s): Imai T, Yamazaki T, Sakano H
  • Organizer: Janelia Farm Conference Constructing Neural Circuits.
  • Place of Presentation: Ashburn, VA, USA(ポスター発表)
• [Presentation] Pre-Target Axon-Axon Interactions Establish the Neural Map Topography. (2009)
  • Author(s): Imai T, Yamazaki T, Sakano H
  • Organizer: Keystone Symposia Chemical Senses : Receptors and Circuits.
  • Place of Presentation: Tahoe City, CA, USA(口頭発表, ポスター発表)
• [Presentation] Pre-target axon sorting for the topographic map formation in the mouse olfactory system (2009)
  • Author(s): 今井猛, Yamazaki T, Sakano H
  • Organizer: Janelia Farm Conference Constructing Neural Circuits
  • Place of Presentation: Ashburn, VA, USA
• [Presentation] Roles of Axon-Axon Interactions in the Formation and Maintenance of the Mouse Olfactory Map (2009)
  • Author(s): 今井猛, Yamazaki T, Sakano H
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜、神奈川県
• [Presentation] Pre-Target Axon-Axon Interactions Establish the Neural Map Topograp by (2009)
  • Author(s): Imai T, Yamazaki T, Sakano H.
  • Organizer: Keystone Symposia Chemical Senses : Receptors and Circuits
  • Place of Presentation: Tahoe City
• [Presentation] Axon-axon interaction in the neural map formation. (2008)
  • Author(s): Imai T, Yamazaki T, Sakano H
  • Organizer: Cold Spring Harbor Laboratory Meeting : Axon Guidance, Synaptogenesis & Neural Plasticity.
  • Place of Presentation: ニューヨーク(口頭発表)
• [Presentation] Novel Mechanisms of Glomerular Map Formation by Sorting Axons of Olfactory Sensory Neurons (2008)
  • Author(s): Imai T, Yamazaki T, Sakano H
  • Organizer: 第31回日本神経科学大会 Neuroscience2008
  • Place of Presentation: 東京(口頭発表)
• [Presentation] Novel Mechanisms of Glomerular Map Formation, by Sorting Axons of Olfactory Sensory Neurons (2008)
  • Author(s): Imai T, Yamazaki T, Sakano H
  • Organizer: 第31回日本神経科大会Neuroscience2008
  • Place of Presentation: 東京
• [Presentation] Axon-axon interaction in the neural map formation (2008)
  • Author(s): Imai T, Yamazaki T, Sakano H.
  • Organizer: Cold Spring Harbor Laboratory Meeting: Axon G uidance, Synaptogenesis & Neural Plasticity
  • Place of Presentation: New York
• [Remarks] ホームページ等
  • URL: http://www.cdb.riken.go.jp/jp/02_research/0202_creative26.html
• [Remarks]
  • URL: http://www.cdb.riken.jp/jp/02_research/0202_creative26.html