Establishment of biological foundation on asymmetry of the brain

• Project/Area Number: 20509009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Hokkaido University (2010); National Institute for Physiological Sciences (2008-2009)
• Principal Investigator: KAWAKAMI Ryosuke Hokkaido University, 電子科学研究所, 助教 (40508818)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,940,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: ニューロン / シナプス / 神経回路

Research Abstract

In the present study, we tried to clarify biological relevance for the asymmetry of mouse brain by analyzing internal organs inversion mouse's (iv mouse) cranial nerve circuit what meaning right and left asymmetry in the synapse. As a result, functional asymmetry existed also in the cerebral cortex nerve system. This suggested the possibility that a research for asymmetry on the mouse brain leads to a research for laterality on the higher order function of human brain.

Research Products

• [Journal Article] Comprehensive behavioural study of GluR4 knockout mice : implication in cognitive function. (2010)
  • Author(s): N.Sagata, A.Iwaki, T.Aramaki, N.Tsunekawa, K.Takao, S.Kura, T.Tsuzuki, R.Kawakami, I.Ito, T.Kitamura, H.Sugiyama, T.Miyakawa, Y.Fukumaki
  • Journal Title: Genes, Brain and Behavior 9 Pages: 899-909
  • Peer Reviewed
• [Journal Article] Comprehensive behavioural study of GluR4 knockout mice : implication in cognitive function (2010)
  • Author(s): N.Sagata, A.Iwaki, T.Aramaki, N.Tsunekawa, K.Takao, S.Kura, T.Tsuzuki, R.Kawakami, I.Ito, T.Kitamura, H.Sugiyama, T.Miyakawa, Y.Fukumaki
  • Journal Title: Genes, Brain and Behavior Volume: 9 Pages: 899-909
  • Peer Reviewed
• [Journal Article] Right isomerism of the brain in inversus viscerum mutant mice. (2008)
  • Author(s): R.Kawakami, Dobi A, Shigemoto R, Ito I
  • Journal Title: PLoS ONE. 3
  • NAID: 120002695755
  • Peer Reviewed
• [Journal Article] Right isomerism of the brain in inversus viscerum mutant mice (2008)
  • Author(s): Kawakami R, Dobi A, Shigemoto R, Ito I.
  • Journal Title: PLoS ONE 3
  • NAID: 120002695755
  • Peer Reviewed
• [Presentation] Morphological characterization of left and right hippocampal pyramidal cell synapses (2010)
  • Author(s): 川上良介、重本隆一
  • Organizer: 第16回Takeda Science Foundation Symposium on Bioscience
  • Place of Presentation: 東京
  • Year and Date: 2010-12-01
• [Presentation] Morphological characterization of left and right hippocampal pyramidal cell synapses (2010)
  • Author(s): Ryosuke Kawakami, Ryuichi Shigemoto
  • Organizer: The 16th Takeda Science Foundation Symposium on Bioscience
  • Place of Presentation: シェラトン都ホテル東京東京
• [Presentation] マウス海馬CA1-CA1錐体細胞シナプスにおける左右半球間の形態学的特徴 (2009)
  • Author(s): 川上良介、重本隆一
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] 「マウス海馬CA1-CA1錐体細胞シナプスにおける左右半球間の形態学的特徴 (2009)
  • Author(s): 川上良介、重本隆一
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-09-17
• [Presentation] Morphological characterization of left and right hippocampal CA1-CA1 pyramidal cell synapses (2009)
  • Author(s): 川上良介、重本隆一
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-07-30
• [Presentation] Morphological characterization of left and right hippocampal CA1-CA1 pyramidal cell synapses. (2009)
  • Author(s): 川上良介、重本隆一
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28