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The investigation of the effects of electromagnetic fields on insulin-secreting cells

Research Project

Project/Area Number 20510046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHirosaki University

Principal Investigator

SAKURAI Tomonori  Hirosaki University, 生存圏研究所, 特定准教授 (90400142)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords糖尿病 / 電磁界 / インスリン分泌細胞 / サイトカイン刺激 / 極低周波 / 定常磁場 / 電磁波 / 強定常磁場 / インターロイキン-1β / インターフェロン-γ
Research Abstract

The cytokine-induced dysfunction of insulin-secreting cells is a mechanism of occurrence of diabetes. In this study, the effects of exposure to electromagnetic fields, to which one are exposed in daily life, on cytokine-induced dysfunction of insulin-secreting cells were investigated. The weak electromagnetic fields did not affect cytokine-induced dysfunction of insulin-secreting cells, and the strong electromagnetic fields, which are 50-100 times larger than that generated from home appliances, enhanced cytokine-induced dysfunction.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (16 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Analysis of Gene Expression in a Human-derived Glial Cell Line Exposed to 2.45 GHz Continuous Radiofrequency Electromagnetic Fields.2011

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      Journal of Radiation Research

      Volume: 52 Pages: 185-192

    • NAID

      10027956684

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ionising irradiation-induced inhibition of differentiation of C3H10T1/2 cells to the osteoblastic lineage.2011

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      International Journal of Radiation Biology

      Volume: 87(in press)

    • NAID

      120004225592

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shingo Terashima, Junji Miyakoshi. Effects of strong static magnetic fields used in magnetic resonance imaging on insulin-secreting cells.2009

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      Bioelectromagnetics誌 30巻

      Pages: 1-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biological effects of strong static magnetic fields on insulin-secreting cells.2009

    • Author(s)
      Tomonori Sakurai, Junji Miyakoshi.
    • Journal Title

      Journal of Physics : Conference Series誌 156巻

      Pages: 12014-12014

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intermediate frequency magnetic fields generated by an induction heating (IH) cooktop do not affect genotoxicities and expression of heat shock proteins2009

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      International of Radiation biology 85

      Pages: 883-890

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological effects of strong static magnetic fields on insulin-secreting cells2009

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      Journal of Physics : Conference Series 156

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of strong static magnetic fields used in magnetic resonance imaging on insulin-secreting cells2009

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      Bioelectromagnetics 30

      Pages: 1-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of insulin-like growth factor-I on decrease in myogenic differentiation by ionizing radiation2009

    • Author(s)
      Tomonori Sakurai
    • Journal Title

      International Journal of Radiation Biology 85

      Pages: 153-158

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Microarray analysis of human-derived glial cells exposed to 2.45 GHz radiofrequency electromagnetic fields2011

    • Author(s)
      Tomonori Sakurai
    • Organizer
      10th International Conference of European Bioelectromagnetics Association
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2011-02-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 強定常磁場による筋管の配向現象2010

    • Author(s)
      櫻井智徳
    • Organizer
      第5回日本磁気科学会年次大会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] X線誘発筋管形成阻害に対する増殖因子の効用2010

    • Author(s)
      櫻井智徳
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of extremely low frequency magnetic fields on insulin-secreting cells.2010

    • Author(s)
      櫻井智徳, 清川倫子, 宮越順二
    • Organizer
      AP-RASC'10
    • Place of Presentation
      富山市
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of extremely low frequency magnetic fields on insulin-secreting cells2010

    • Author(s)
      Tomonori Sakurai
    • Organizer
      AP-RASC'10
    • Place of Presentation
      富山市
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 増殖因子によるX 線誘発筋形成阻害の軽減2010

    • Author(s)
      櫻井智徳
    • Organizer
      第49回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of gene expression in glial cells exposed to radiofrequency electromagnetic fields using microarray2010

    • Author(s)
      Tomonori Sakurai
    • Organizer
      The Bioelectromagnetics Society 32nd Annual Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] アストロサイト前駆細胞に対する強定常磁場の影響2009

    • Author(s)
      櫻井智徳
    • Organizer
      第4回日本磁気科学会年次大会
    • Place of Presentation
      松本市
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 強定常磁場の神経細胞への影響2009

    • Author(s)
      櫻井智徳
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] マイクロアレイ法による高周波電磁波の影響評価2009

    • Author(s)
      櫻井智徳、成田英二郎、清川倫子、多氣昌生、鈴木敬久、宮越順二
    • Organizer
      電気学会マグネティックス研究会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] マイクロアレイ法による高周波電磁波の影響評価2009

    • Author(s)
      櫻井智徳
    • Organizer
      マグネティックス研究会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] X線による筋管形成阻害に対するIGFの作用2009

    • Author(s)
      櫻井智徳
    • Organizer
      第48回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      富山市
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] The effects of extremely low frequency magnetic fields on adipogenesis.2009

    • Author(s)
      櫻井智徳, 清川倫子, 宮越順二
    • Organizer
      BioEM2009
    • Place of Presentation
      ダボス、スイス
    • Year and Date
      2009-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] The effects of extremely low frequency magnetic fields on adipogenesis2009

    • Author(s)
      Tomonori Sakurai
    • Organizer
      BioEM2009
    • Place of Presentation
      Davos, Switzerland
    • Year and Date
      2009-06-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] The effects of strong static magnetic fields on astrocyte differentiation2009

    • Author(s)
      Tomonori Sakurai
    • Organizer
      BioEM2009
    • Place of Presentation
      Davos, Switzerland
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] IGF-1によるX線誘発筋管形成阻害の緩和2008

    • Author(s)
      櫻井智徳
    • Organizer
      日本放射線影響学会第51回大会
    • Place of Presentation
      北九州市
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.rish.kyoto-u.ac.jp/space/people/sakurai/SakuraiTopPage.htm

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Method of increasing amount of insulin production and/or secreted by insulin-producing cells2008

    • Inventor(s)
      宮越順二、櫻井智徳
    • Industrial Property Rights Holder
      弘前大学
    • Acquisition Date
      2008-09-25
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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