Study on the Mechanism of Apoptosis Induced by Ionizing Radiation in C3H Mouse Macrophages

Research Project

Project/Area Number	20510058
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Risk sciences of radiation/Chemicals
Research Institution	National Institute of Radiological Sciences
Principal Investigator	KUBOTA Yoshihisa National Institute of Radiological Sciences, 放射線防護研究センター, チームリーダー (70161685)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	放射線 / 感受性 / アポトーシス / マウス / マクロファージ
Research Abstract	It has been elucidated that radiation-induced apoptosis in C3H mouse macrophages is attributed to the decreased protein synthesis that subsequently resulted in the depletion of Mcl-1, an anti-apoptotic Bcl-2 protein. The present study revealed that radiation-induced suppression of global protein synthesis resulted from the sequential intracellular responses from DNA damages to eIF2alpha phosphorylation.

Report

(4 results)