Development of a novel DNA damage sensor mouse model.
| Project/Area Number |
20510059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KOIKE Manabu 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (70280740)
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Aki 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 准研究員 (50415410)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Ku70 / DSB / GFP / DNA repair / Ku80 |
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| Research Abstract |
We generated transgenic mice that were overexpressed GFP-Ku70.Furthermore, we confirmed that the GFP-Ku70 is a useful tool as a detection marker of DNA damaged sites in living mouse epithelial cells.
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Report
(4 results)
Research Products
(5 results)
