The effect of environmental chemicals on the interaction of thyroid hormone receptor and retinoic acid receptor-related orphan receptor (ROR).
| Project/Area Number |
20510061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Gunma University |
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Principal Investigator |
IWASAKI Toshiharu Gunma University, 大学院・医学系研究科, 講師 (80375576)
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| Co-Investigator(Kenkyū-buntansha) |
KOIBUCHI Noriyuki 群馬大学, 大学院・医学系研究科, 教授 (80234681)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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|---|
| Keywords | 小脳初代培養細胞 / Purkinje細胞 / 顆粒細胞 / 環境化学物質 / 甲状腺ホルモン / 脳発達抑制 / ROR / オーファン受容体 / 脳発達 / 相互作用 |
|---|
| Research Abstract |
(1) We investigated the effect of interaction between thyroid hormone receptor (TR) and retinoic acid receptor-related orphan receptor (ROR).
(2) We investigated the effects of Brominated Organic Chemicals (BOCs) such as polybrominated diphenylethers (PBDEs) on TR-related signaling using newly developed primary culture-based assays.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) alpha in breast cancer cells : identification of a novel ROR response element.2009
Author(s)
Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N
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Journal Title
J Biol Chem. 284
Pages: 17711-17719
Related Report
Peer Reviewed
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[Journal Article] Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor.2008
Author(s)
Rokutanda N, Iwasaki T, Odawara H, Nagaoka R, Miyazaki W, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, Iino Y, Morishita Y, Koibuchi N
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Journal Title
Endocrine. 33
Pages: 305-316
Related Report
Peer Reviewed
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[Book] 生物の事典2010
Author(s)
石原勝敏, 他編集、岩崎俊晴, 他
Total Pages
542
Publisher
朝倉書店
Related Report
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[Book] 生物学大事典
Author(s)
岩崎俊晴
Publisher
東京化学同人(In press)
Related Report
