Analysis of extracellular distribution and cellular uptake system of thyroid-disrupting chemicals
| Project/Area Number |
20510062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Shizuoka University |
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Principal Investigator |
YAMAUCHI Kiyoshi Shizuoka University, 理学部, 教授 (50201827)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Akinori 静岡大学, 理学部, 助教 (70432193)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Hiroaki 静岡大学, 理学部, 准教授 (90216854)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 甲状腺ホルモン / 内分泌撹乱 / 化学物質 / 甲状線ホルモン / 内分秘撹乱 |
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| Research Abstract |
To clarify the factors that influence the biological effects of endocrine disrupting chemicals within target cells, we investigated the interaction of 2,4,6-triiodophenol (TIP) and ioxynil (IOX), potent thyroid hormone disrupting chemicals, with serum proteins from rainbow trout, bullfrog, chicken, pig, and rat. [^<125>I]-chemicals bound weakly to proteins in trout and bullfrog serum, and strongly to proteins in chicken, pig, and rat serum samples. A weak interaction of [^<125>I]-chemicals with tadpole serum proteins accelerated [^<125>I]-chemical cellular uptake in vitro. The cellular uptake of [^<125>I]-chemicals suggested the presence of phenol-specific cellular uptake system. The differences in the molecular and binding properties of chemical-binding proteins among vertebrates, and a phenol-specific cellular uptake system would affect in part the cellular actions of these chemicals.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article]2009
Author(s)
K.Yamauchi
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Journal Title
Transthyretin and Endocrine Disruptors. In : Recent Advances in Transthyretin Evolution, Structure and Biological Functions(Springer-Verlag)
Related Report
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