| Project/Area Number |
20510065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
FUJIMOTO Nariaki 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Shigeyuki 日本薬科大学, 薬学部, 教授 (40136057)
SUGIHARA Kazumi 広島大学, 医歯薬総合研究科, 准教授 (20271067)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 甲状腺ホルモン / 内分泌かく乱物質 / 子供の環境リスク / 甲状腺ホルモン応答遺伝子 / 発達期影響 / 新生児期曝露 / プロム化難燃剤 / 甲状腺ホメオスタシス / ブロム化難燃剤 |
|---|
| Research Abstract |
The expression of rat liver genes was determined by a cDNA microarray method to identify the thyroid hormone responsive genes. The identified genes include RLT3-2, RLT3-13, RLT3B-24 and RLT3B-49. In rats, neonatal exposure to thyroid hormones irreversibly altered the expression profile of these genes in adulthood, which suggested these genes could be useful markers for the neonatal effects of thyroid hormone disrupting chemicals. In addition, we established an improved thyroid hormone reporter gene assay to determine environmental chemicals exhibiting weak thyroid hormone activity.
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