Research for effect of cadmium induced-toxicity on FGF23 signaling

• Project/Area Number: 20510068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KUROSU Hiroshi Tokyo Women's Medical University, 大学院・医歯薬学総合研究科, 准教授 (40468690)
• Co-Investigator(Renkei-kenkyūsha): MATSUOKA Masato 東京女子医科大学, 医学部, 教授 (50209516)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: カドミウム / 恒常性維持機構

Research Abstract

Cadmium is an important occupational and environmental pollutant. It has a biological half-life exceeding 20 years, and may accumulate in various organs such as kidney. The present results showed that cadmium exposure affected FGF23 induced-gene expression which was related with vitamin D metabolism.

Research Products

• [Journal Article] Mangelsdorf DJ, Kliewer SA Research resource : Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010)
  • Author(s): Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M
  • Journal Title: Mol Endocrinol 24 Pages: 2050-2064
• [Journal Article] Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. (2010)
  • Author(s): Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 407-412
• [Journal Article] Research resource : Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010)
  • Author(s): Fon Tacer K
  • Journal Title: Molecular Endocrinology Volume: 24 Pages: 2050-2064
  • Peer Reviewed
• [Journal Article] Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-HIotho complex formation (2010)
  • Author(s): Regina Goetz
  • Journal Title: Proceeding of the National Academy of Sciences of the United States of America 107 Pages: 407-412
  • Peer Reviewed
• [Journal Article] NaF activates MAPKs and induces apoptosis in odontoblast-like cells (2009)
  • Author(s): Karube H, Nishitai G, Inageda K, Kurosu H, Matsuoka M
  • Journal Title: J Dent Res 88 Pages: 461-465
• [Journal Article] Regulation of renal outer medullary potassium channel and renal K^+ excretion by klotho. (2009)
  • Author(s): Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe OW, Huang CL
  • Journal Title: Mol Pharmacol 38 Pages: 38-46
• [Journal Article] Endocrine FGFs as regulators of metabolic homeostasis. (2009)
  • Author(s): 黒須洋, 黒尾誠
  • Journal Title: Biofactors Review 35 Pages: 52-60
• [Journal Article] The Klotho gene family as a regulator of endocrine fibroblast growth factors. (2009)
  • Author(s): 黒須洋, 黒尾誠
  • Journal Title: Mol Cell Endocrinol. Review 299 Pages: 72-78
• [Journal Article] KlothoとFGF19サブファミリー (2009)
  • Author(s): 黒須洋、黒尾誠
  • Journal Title: 季刊 腎と骨代謝 22 Pages: 113-126
• [Journal Article] Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. (2009)
  • Author(s): Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-o M, Huang CL
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 9805-9810
• [Journal Article] NaF activates MAPKs and induces apoptosis in odontoblast-like cells (2009)
  • Author(s): Hiroko Karube
  • Journal Title: Journal of Dental Research 88 Pages: 461-455
  • Peer Reviewed
• [Journal Article] Regulation of renal outer medullary potassium channel and renal K^+ excretion by Klotho (2009)
  • Author(s): Seung-Kuy Cha
  • Journal Title: Molecular Pharmacology 76 Pages: 72-78
  • Peer Reviewed
• [Journal Article] Endocrine fibroblast growth factors as regulators of metabolic homeostasis (2009)
  • Author(s): Hiroshi Kurosu
  • Journal Title: Biofactors 35 Pages: 52-60
  • Peer Reviewed
• [Journal Article] The Klotho gene family as a regulator of endocrine fibroblast growth factors. (2009)
  • Author(s): Hiroshi Kurosu
  • Journal Title: Molecular and Cellular Endocrinology 299 Pages: 72-78
  • Peer Reviewed
• [Journal Article] KlothoとFGF19サブファミリー (2009)
  • Author(s): 黒須 洋
  • Journal Title: 季刊 腎と骨代謝 22 Pages: 113-126
• [Journal Article] The Klotho gene family and the endocrine fibroblast growth factors. (2008)
  • Author(s): 黒須洋, 黒尾誠
  • Journal Title: Curr Opin Nephrol Hypertens. Review 17 Pages: 368-372
• [Journal Article] Klotho遺伝子からみた老化 (2008)
  • Author(s): 黒須洋、黒尾誠
  • Journal Title: Surgery Frontier 387-393
• [Journal Article] KlothoファミリーとエンドクラインFGFによる生体の恒常性維持制御 (2008)
  • Author(s): 黒須洋、黒尾誠
  • Journal Title: 内分泌・糖尿病科 26 Pages: 527-535
• [Journal Article] The Klotho gene family and the endocrine fibroblast growth factors. (2008)
  • Author(s): Hiroshi Kurosu
  • Journal Title: Current Opinion in Nephrology and Hypertension 17 Pages: 368-372
  • Peer Reviewed
• [Journal Article] Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. (2008)
  • Author(s): Seung-Kuy Cha
  • Journal Title: Proceeding of the National Academy of Sciences of the United States of America 105 Pages: 9805-9810
  • Peer Reviewed
• [Journal Article] Klotho遺伝子からみた老化 (2008)
  • Author(s): 黒須 洋
  • Journal Title: Surgery Frontier 15 Pages: 387-393
• [Journal Article] Klotho分子ファミリーとエンドクラインFGPによる生体の恒常性維持制御 (2008)
  • Author(s): 黒須 洋
  • Journal Title: 内分泌・糖尿病科 26 Pages: 527-535
• [Presentation] プロサイモシンαミクログリア活性化機構の解析 (2009)
  • Author(s): 黒須洋
  • Organizer: 第62回日本薬理学会西南部会
  • Place of Presentation: 松山
  • Year and Date: 2009-11-28
• [Presentation] リゾホスファチジン酸によるミクログリア活性化とATP遊離を介する間接的BDNF産生機構 (2009)
  • Author(s): 植村朋香
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] フッ化ナトリウム曝露による象牙芽細胞様細胞株のアポトーシス (2009)
  • Author(s): 軽部 裕代
  • Organizer: 第79回 日本衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-31
• [Presentation] フッ化ナトリウム曝露による象牙芽細胞様細胞株のアポトーシス軽部
  • Author(s): 裕代、西躰元、黒須洋、松岡雅人
  • Organizer: 第79回日本衛生学会
• [Presentation] リゾホスファチジン酸によるミクログリア活性化とATP遊離を介する間接的BDNF産生機構
  • Author(s): 植村朋香、藤田亮介、黒須洋、植田弘師
  • Organizer: 第82回日本生化学会大会
• [Presentation] 西南部会プロサイモシンαミクログリア活性化機構の解析
  • Author(s): 黒須洋、植村朋香、藤村一輝、黒須洋、植田弘師
  • Organizer: 第62回日本薬理学会
• [Presentation] 九州支部会モルヒネ鎮痛耐性を制御するアンチオピオイド機能の解明
  • Author(s): 三浦裕、西建也、荒木康平、内田仁司、黒須洋、植田弘師
  • Organizer: 第27回日本薬学会
• [Presentation] 九州支部会オピオイド受容体欠損マウスへの脳領域特異的遺伝子レスキューと疼痛モダリティーとの関連
  • Author(s): 西建也、三浦裕、荒木康平、内田仁司、黒須洋、植田弘師
  • Organizer: 第27回日本薬学会
• [Remarks]
  • URL: http://www.twmu.ac.jp/Basic/hygienel/index.html