Research for effect of cadmium induced-toxicity on FGF23 signaling
| Project/Area Number |
20510068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KUROSU Hiroshi Tokyo Women's Medical University, 大学院・医歯薬学総合研究科, 准教授 (40468690)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUOKA Masato 東京女子医科大学, 医学部, 教授 (50209516)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | カドミウム / 恒常性維持機構 |
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| Research Abstract |
Cadmium is an important occupational and environmental pollutant. It has a biological half-life exceeding 20 years, and may accumulate in various organs such as kidney. The present results showed that cadmium exposure affected FGF23 induced-gene expression which was related with vitamin D metabolism.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.2010
Author(s)
Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M
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Journal Title
Proc Natl Acad Sci USA 107
Pages: 407-412
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