| Project/Area Number |
20510070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
YOSHIHISA Kato Tokushima Bunri University, 薬学部, 教授 (90161132)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 甲状腺ホルモン撹乱 / サイロキシン / PCB / UDP-glucuronosyltransferase / トランスサイレチン / CB153 / 肝臓 / マウス / CB126 / 4-OH-CB187 |
|---|
| Research Abstract |
In general, PCBs, including 3,3',4,4',5-pentachlorobiphenyl (CB126) and Aroclor 1254, have the abilities to decrease serum thyroid hormone levels in rats and mice, and the decreases are thought to occur through the induction of thyroxine (T_4)-UDP-glucuronosyltransferases (UDPGTs), especially UGT1A1 and UGT1A6. The present findings indicate that for the first time the PCB-mediated decrease in the serum T_4 level in mice, hamsters, rats and guinea pigs occurs mainly through an increase in the accumulation level of T_4 in the liver.
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