A novel mechanism for polychlorinated biphenyl-induced decrease in serum thyroxine level
| Project/Area Number |
20510070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
YOSHIHISA Kato Tokushima Bunri University, 薬学部, 教授 (90161132)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 甲状腺ホルモン撹乱 / サイロキシン / PCB / UDP-glucuronosyltransferase / トランスサイレチン / CB153 / 肝臓 / マウス / CB126 / 4-OH-CB187 |
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| Research Abstract |
In general, PCBs, including 3,3',4,4',5-pentachlorobiphenyl (CB126) and Aroclor 1254, have the abilities to decrease serum thyroid hormone levels in rats and mice, and the decreases are thought to occur through the induction of thyroxine (T_4)-UDP-glucuronosyltransferases (UDPGTs), especially UGT1A1 and UGT1A6. The present findings indicate that for the first time the PCB-mediated decrease in the serum T_4 level in mice, hamsters, rats and guinea pigs occurs mainly through an increase in the accumulation level of T_4 in the liver.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo-p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice.2010
Author(s)
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Takashi Okura, Shin-ichi Ikushiro, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa
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Journal Title
Drug Metab.Dispos. 38
Pages: 150-156
Related Report
Peer Reviewed
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[Journal Article] 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver.2009
Author(s)
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa
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Journal Title
Drug Metab.Dispos. 37
Pages: 2095-2102
Related Report
Peer Reviewed
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[Journal Article] Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries.2009
Author(s)
Koichi Haraguchi, Akio Koizumi, Kayoko Inoue, Kouji H. Harada, Toshiaki Hitomi, Mutsuko Minata, Miyako Tanabe, Yoshihisa Kato, Eri Nishimura, Yoshiaki Yamamoto, Takao Watanabe, Katsunobu Takenaka, Shigeki Uehara, Hye-Ran Yang, Min-Young Kim, Chan-Seok Moon, Hae-Sook Kim, Peiyu Wang, Aiping Liu, Nguyen Ngoc Hung
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Journal Title
Environ. Int. 35
Pages: 1072-1079
Related Report
Peer Reviewed
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[Presentation] Species difference in the in vitro metabolism of 2,2',3,4,4',5,5'-heptachlorobiphenyl (CB180).2010
Author(s)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Futoshi Matsubara, Nobuyuki Koga
Organizer
30th International Symposium on Halogenated Persistent Organic Pollutants, Organohalogen Compounds(72 1796-1799)
Place of Presentation
San Antonio, USA.
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[Presentation] A possible mechanism for the decrease in serum thyroxine level by TCDD-like PCB, 3,3',4,4',5-pentachlorobiphenyl in mice.2009
Author(s)
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa
Organizer
29th International Symposium on Halogenated Persistent Organic Pollutants, Organohalogen Compounds(71 119-122)
Place of Presentation
Beijing, China.
Related Report
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[Presentation] Metabolism of 2,2',3,4',5',6-hexachlorobiphenyl (CB149) by liver microsomes from rats, hamsters, guinea pigs and humans.2009
Author(s)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Nobuyuki Koga
Organizer
29th International Symposium on Halogenated Persistent Organic Pollutants, Organohalogen Compounds(71 308-311)
Place of Presentation
Beijing, China.
Related Report
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[Presentation] A possible mechanism for the decrease in serum thyroxine level by 4-OH-2,2',3,4',5,5',6-heptachlorobiphenyl in mice.2008
Author(s)
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa
Organizer
28th International Symposium on Halogenated Persistent Organic Pollutants, Organohalogen Compounds(70 1601-1604)
Place of Presentation
Birmingham, UK.
Related Report
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[Presentation] Metabolism of 2,2',3,4',5,5'-hexachlorobiphenyl (CB146) by liver microsomes from rats, hamsters and guinea pigs.2008
Author(s)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Mikiko Matsuoka, Nobuyuki Koga
Organizer
28th International Symposium on Halogenated Persistent Organic Pollutants, Organohalogen Compounds(70 1185-1188)
Place of Presentation
Birmingham, UK.
Related Report
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[Book] Persistent Organic Pollutants (POPs) Research in Asia(Edited by Masatoshi Morita)(The distribution of metabolites of 2,2',3,4,4',5',6-heptachlorobiphenyl (CB183) in rats and guinea pigs.)2008
Author(s)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Mikiko Matsuoka, Tetsuya Endo, Nobuyuki Koga
Publisher
The DIOXIN2007 International symposium organizing committee.
Related Report
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[Book] Persistent Organic Pollutants (POPs) Research in Asia(Edited by Masatoshi Morita)(The formation of a catechol metabolite of 2,2',4,5,5'-pentachlorobiphenyl (CB101) by liver microsomes from rats, hamsters, guinea pigs and humans.)2008
Author(s)
Nobuyuki Koga, Chiho Ohta, Koichi Haraguchi, Mikiko Matsuoka, Yoshihisa Kato, Tetsuya Endo
Publisher
The DIOXIN2007 International symposium organizing committee.
Related Report
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