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Development of Molecular Sorter using Nanofluidic Device

Research Project

Project/Area Number 20510114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMOTO Takatoki  The University of Tokyo, 大学院・理工学研究科, 准教授 (20322688)

Co-Investigator(Renkei-kenkyūsha) NOJIMA Takahiko  北里大学, 一般教育部自然科学教育センター (00291930)
FUKUBA Tatsuhiro  東京大学, 生産技術研究所, 特任准教授 (80401272)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords1分子イメージング / ナノ計測 / 1分子操作 / ナノ流体デバイス / 電気インピーダンス測定 / マイクロ化学システム / MEMS / NEMS / 1分子科学 / 分子操作 / ナノ界面・表面 / ナノバイオロジー / 1分子・ナノ計測 / 1分子計測 / マイクロ・ナノデバイス / ナノバイオ / システムオンチップ
Research Abstract

This work is to develop a single-molecule sensing device using nanofluidic system, which has a channel having tens to hundreds nanometer sized width and height. As results, we have successfully demonstrated the single DNA molecule detection in the nanochannel by ultra-sensitive (fA order) electric measurement. Furthermore, we have also successfully demonstrated an on-chip electric measurement circuit, which was integrated on the nanofluidic chip to realize portable system.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (16 results)

  • [Journal Article] マイクロ\ナノ流体デバイスのナノバイオ応用2011

    • Author(s)
      山本貴富喜
    • Journal Title

      機械の研究 Vol.63, No.2

      Pages: 117-124

    • NAID

      40018697491

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] マイクロ・ナノ流体デバイスのナノバイオ応用2011

    • Author(s)
      山本貴富喜
    • Journal Title

      機械の研究

      Volume: 63 Pages: 117-124

    • NAID

      40018697491

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Nanofluidic Single-molecule Sorting of DNA : A New Concept in Separation and Analysis of Biomolecul2010

    • Author(s)
      Takatoki Yamamoto, Teruo Fujii
    • Journal Title

      Nanotechnology Vol.21, No.39

      Pages: 395502-395502

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonlinear Electrical Impedance Measurement Controlling Conformation of DNA2010

    • Author(s)
      Takatoki Yamamoto, Sang-Wook Lee, Teruo Fujii
    • Journal Title

      Journal of Robotics and Mechatronics Vol.22, No.5

      Pages: 601-607

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] シリコーンゴム製マイクロ流体デバイスのライフサイエンス応用2010

    • Author(s)
      山本貴富喜
    • Journal Title

      材料の科学と工学 Vol.47 No.5

      Pages: 6-11

    • NAID

      10027688175

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nanofluidic single-molecule sorting of DNA : a new concept in separation and analysis of biomolecule toward ultimate level performance2010

    • Author(s)
      Takatoki Yamamoto, et al.
    • Journal Title

      Nanotechnology

      Volume: 21 Pages: 395502-395509

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonlinear Electrical Impedance Measurement Controlling Conformation of DNA2010

    • Author(s)
      Takatoki Yamamoto, et al.
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: 22 Pages: 601-607

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シリコーンゴム製マイクロ流体デバイスのライフサイエンス応用2010

    • Author(s)
      山本貴富喜
    • Journal Title

      材料の科学と工学

      Volume: 47 Pages: 6-11

    • NAID

      10027688175

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Biomolecular Nano-Flow-Sensor to Measure Near-Surface Flow2010

    • Author(s)
      Sang-Wook Lee・Haruyuki Kinoshita・Hiroyuki Noji・Teruo Fujii・Takatoki Yamamoto
    • Journal Title

      Nanoscale Research Letters 5

      Pages: 296-301

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymerase chain reaction-based biochemical logic gate coupled with cell-free transcription-translation of green fluorescent protein as a report gate2008

    • Author(s)
      Takahiko Nojima, Takatoki Yamamoto Hiroshi Kimura, Teruo Fuji
    • Journal Title

      CHEMICAL COMMUNICATIONS 32

      Pages: 3371-3373

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Multiphysics simulation to design micro/nanofluidic device for biotechnology applications2010

    • Author(s)
      Takatoki Yamamoto
    • Organizer
      COMSOL conference of Tokyo 2010
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Multiphysics simulation to design micro/nanofluidic device for biotechnology applications2010

    • Author(s)
      山本貴富喜
    • Organizer
      COMSOL conference of Tokyo
    • Place of Presentation
      東京
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 両親媒性マクロ構造体による自己組織化の研究2010

    • Author(s)
      山腰一平, 山本貴富喜
    • Organizer
      第2回マイクロナノ工学シンポジウム
    • Place of Presentation
      島根
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電気的1分子検出のためのナノ流体デバイスの研究2010

    • Author(s)
      淵上裕次郎, 山本貴富喜
    • Organizer
      第2回マイクロナノ工学シンポジウム
    • Place of Presentation
      島根
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Direct bonding of solid-state silicone by atmospheric-pressure surface excitation2010

    • Author(s)
      Wataru Okada, Takatoki Yamamoto
    • Organizer
      The 27th Sensor Symposium on Sensors, Micromachines and Applied Systems
    • Place of Presentation
      島根
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロ・ナノ流体デバイスのライフサイエンス応用2010

    • Author(s)
      山本貴富喜
    • Organizer
      日本機械学会,実験流体力学-マイクロ流れ実験の基礎と応用-
    • Place of Presentation
      東京
    • Year and Date
      2010-08-24
    • Related Report
      2010 Final Research Report
  • [Presentation] NANOFLUIDIC SINGLE-MOLECULE SORTER CONCEPTUALLY PROVEN BY SORTING OF DNA2010

    • Author(s)
      T.Yamamoto, T.Fujii
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2010) 1874-1876
    • Place of Presentation
      Groningen, The Netherland
    • Related Report
      2010 Final Research Report
  • [Presentation] 両親媒性マクロ構造体による自己組織化の研究2010

    • Author(s)
      山腰一平, 山本貴富喜
    • Organizer
      第2回マイクロナノ工学シンポジウム, 講演論文集 185-186
    • Place of Presentation
      島根
    • Related Report
      2010 Final Research Report
  • [Presentation] 電気的1分子検出のためのナノ流体デバイスの研究2010

    • Author(s)
      淵上裕次郎, 山本貴富喜
    • Organizer
      第2回マイクロナノ工学シンポジウム, 講演論文集 15-16
    • Place of Presentation
      島根
    • Related Report
      2010 Final Research Report
  • [Presentation] Direct bonding of solid-state silicone by atmospheric-pressure surface excitation2010

    • Author(s)
      Wataru Okada, Takatoki Yamamoto
    • Organizer
      The 27th Sensor Symposium on Sensors, Micromachines and Applied Systems 117
    • Place of Presentation
      Shimane
    • Related Report
      2010 Final Research Report
  • [Presentation] NANOFLUIDIC SINGLE-MOLECULE SORTER CONCEPTUALLY PROVEN BY SORTING OF DNA2010

    • Author(s)
      T.Yamamoto, T.Fujii
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Groningen, The Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] AN AUTOMATED EMBRYO CULTURE SYSTEM USING DYNAMIC MICROARRAY2010

    • Author(s)
      H.Kimura, H.Nakamura, T.Kurakazu, T.Yamamoto, S.Takeuchi, Y.Sakai, T.Fujii
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Groningen, The Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Design using COMSOL for life science application of microfabrication technology2009

    • Author(s)
      Takatoki Yamamoto, Teruo Fujii
    • Organizer
      COMSOL conference of Tokyo 2009
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 微細加工技術のライフサイエンス応用におけるCOMSOLによる設計例2009

    • Author(s)
      Takatoki Yamamoto
    • Organizer
      COMSOL conference Tokyo 2009
    • Place of Presentation
      日本・東京
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electrical Single-Molecule Detection in Nanochannel for Single-Molecular Sorter2009

    • Author(s)
      Takatoki Yamamoto, Teruo Fujii
    • Organizer
      IEEE NANO2009
    • Place of Presentation
      イタリア・ジェノバ
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 機械学会No.08-59講習会-実験流体力学-マイクロ流れ実験の基礎と応用-2008

    • Author(s)
      山本貴富喜
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-26
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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