| Project/Area Number |
20510184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUKUOKA Yutaka Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 准教授 (30242217)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUSHIMA Hiroshi 東京医科歯科大学, 大学院・疾患生命科学研究部, 特任教授 (50219630)
TANAKA Hiroshi 東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (60155158)
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| Co-Investigator(Renkei-kenkyūsha) |
INAOKA Hidenori 北里大学, 医療衛生学部, 講師 (30282768)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | システムゲノム / がん / マイクロRNA / 遺伝子 / 発現 / マイクロアレイ / microRNA / バイオインフォマティクス / 肝臓がん / 遺伝子発現 / 肝細胞がん |
|---|
| Research Abstract |
To investigate the local effect of miRNA in cancer, we analyzed gene and miRNA expressions in hepatocellular carcinoma (HCC) and surrounding non-tumor tissues. We calculated the Pearson correlation coefficients between miRNAs neighboring genes and compared the coefficients in the tumor and non-tumor tissues. This analysis was repeated for intronic and intergenic miRNAs. Finally, the correlation coefficients between miRNAs and their target genes were compared in the tumor and non-tumor tissues. The results suggested that in HCC, more miRNAs correlated with neighboring genes positively and that the correlation coefficients between the intronic miRNAs and their host genes were higher in HCC. The correlation analysis between miRNAs and their targets suggested that there was no significant difference between the correlation coefficients in the tumor and non-tumor tissues.
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