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OMICS ANALYSIS TO INVESTIGATE ROLES OF MICRORNAS IN CANCER

Research Project

Project/Area Number 20510184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 基礎ゲノム科学
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FUKUOKA Yutaka  Tokyo Medical and Dental University, 大学院・疾患生命科学研究部, 准教授 (30242217)

Co-Investigator(Kenkyū-buntansha) MIZUSHIMA Hiroshi  東京医科歯科大学, 大学院・疾患生命科学研究部, 特任教授 (50219630)
TANAKA Hiroshi  東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (60155158)
Co-Investigator(Renkei-kenkyūsha) INAOKA Hidenori  北里大学, 医療衛生学部, 講師 (30282768)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsシステムゲノム / がん / マイクロRNA / 遺伝子 / 発現 / マイクロアレイ / microRNA / バイオインフォマティクス / 肝臓がん / 遺伝子発現 / 肝細胞がん
Research Abstract

To investigate the local effect of miRNA in cancer, we analyzed gene and miRNA expressions in hepatocellular carcinoma (HCC) and surrounding non-tumor tissues. We calculated the Pearson correlation coefficients between miRNAs neighboring genes and compared the coefficients in the tumor and non-tumor tissues. This analysis was repeated for intronic and intergenic miRNAs. Finally, the correlation coefficients between miRNAs and their target genes were compared in the tumor and non-tumor tissues. The results suggested that in HCC, more miRNAs correlated with neighboring genes positively and that the correlation coefficients between the intronic miRNAs and their host genes were higher in HCC. The correlation analysis between miRNAs and their targets suggested that there was no significant difference between the correlation coefficients in the tumor and non-tumor tissues.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (23 results) Book (1 results)

  • [Journal Article] 次世代オミックス医学への展開2010

    • Author(s)
      田中博、福岡豊
    • Journal Title

      計測と制御 49

      Pages: 537-542

    • NAID

      10026585811

    • Related Report
      2010 Final Research Report
  • [Journal Article] 臨床データの公的利用とトランスレーショナル研究2010

    • Author(s)
      高井貴子、福岡豊、田中博
    • Journal Title

      計測と制御 49

      Pages: 553-557

    • NAID

      10026585838

    • Related Report
      2010 Final Research Report
  • [Journal Article] iCOD : an integrated clinical omics database based on the systems-pathology view of disease,2010

    • Author(s)
      Shimokawa K, Mogushi K, Shoji S, Hiraishi A, Mizushima H, Tanaka H
    • Journal Title

      BMC Genomics 11, Sup4

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of PSF1 promotes the growth of breast cancer cells2010

    • Author(s)
      Nakahara I, Miyamoto M, Shibata T, Akashi-Tanaka S, Kinoshita T, Mogushi K, Oda K, Ueno M, Takakura N, Mizushima H, Tanaka H, Ohta T
    • Journal Title

      Genes Cells 15

      Pages: 1015-1024

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical omics analysis of colorectal cancer incorporating copy number aberrations and gene expression data2010

    • Author(s)
      Yoshida T, Kobayashi T, Itoda M, Muto T, Miyaguchi K, Mogushi K, Shoji S, Shimokawa K, Iida S, Uetake H, Ishikawa T, Sugihara K, Mizushima H, Tanaka H
    • Journal Title

      Cancer Inform 29

      Pages: 147-161

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MUC12 mRNA expression is an independent marker of prognosis in stage II and stage III colorectal cancer2010

    • Author(s)
      Matsuyama T, Ishikawa T, Mogushi K, Yoshida T, Iida S, Uetake H, Mizushima H, Tanaka H, Sugihara K
    • Journal Title

      Int J Cancer 127

      Pages: 2292-2299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 次世代オミックス医学への展開2010

    • Author(s)
      田中博, 福岡豊
    • Journal Title

      計測と制御

      Volume: 49 Pages: 537-542

    • NAID

      10026585811

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 臨床データの公的利用とトランスレーショナル研究2010

    • Author(s)
      高井貴子, 福岡豊, 田中博
    • Journal Title

      計測と制御

      Volume: 49 Pages: 553-557

    • NAID

      10026585838

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The phenotype and genotype experiment object model (PaGE-OM) : a robust data structure for information related to DNA variation2009

    • Author(s)
      Brookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I, Kuroda M, Mizushima H, Thorisson GA, Dash D, Rajeevan H, Darlison MW, Woon M, Fredman D, Smith AV, Senger M, Naito K, Sugawara H
    • Journal Title

      Hum Mutat 30

      Pages: 968-977

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue2009

    • Author(s)
      Yasen M, Mizushima H, Mogushi K, Obulhasim G, Miyaguchi K, Inoue K, Nakahara I, Ohta T, Aihara A, Tanaka S, Arii S, Tanaka H
    • Journal Title

      Cancer Sci 100

      Pages: 472-480

    • NAID

      10025143395

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] シリコーン膜ひずみと膜接着細胞のひずみとの比較2009

    • Author(s)
      小林こず恵、岸亜由美、田中真澄、稲岡秀検、根武谷吾、福岡豊、小林弘祐、野城真理
    • Journal Title

      生体医工学 47

      Pages: 464-469

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] シリコーン膜のひずみと膜接着細胞のみずみとの比較2009

    • Author(s)
      小林こず恵、岸亜由美、田中真澄、稲岡秀検、根武谷吾、福岡豊, ほか
    • Journal Title

      生体医工学 47

      Pages: 464-469

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生命情報の統合的解析-MEと生命情報の架け橋をめざして-2010

    • Author(s)
      福岡豊
    • Organizer
      第25回生体・生理工学シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝細胞がんにおけるmicroRNA発現量と近傍遺伝子発現量の相関解析2010

    • Author(s)
      福岡豊、岩村泰輔、根本翔太、宮口健、飯村諭、内山孝憲、稲岡秀検、Mahmut Y、水島洋、田中真二、有井滋樹、野城真理、田中博、Kohane IS
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Adaptive Threshold for detecting differentially expressed genes in microarray data-a simulation study to investigate its performance2010

    • Author(s)
      福岡豊, 稲岡秀検, 野城真理
    • Organizer
      The 32nd International IEEE EMBS Conference
    • Place of Presentation
      Buenos Aires
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Genome-wide DNA methylation analysis in tumor and normal tissues from lung squamous cell carcinoma and serous cystadenocarcinoma2010

    • Author(s)
      稲岡秀検, 福岡豊, 野城真理
    • Organizer
      IEEE International Conference on Bioinfomatics & Biomedicine
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical gene network analysis on inflammatory bowel disease2010

    • Author(s)
      Suzuki S, Takai-Igarashi T, Fukuoka Y, Tanaka H, Fusaro V, Pivovarov R, Tonellato PJ
    • Organizer
      International Omics Symposium
    • Place of Presentation
      Yokoyama
    • Related Report
      2010 Final Research Report
  • [Presentation] 生命情報の統合的解析-MEと生命情報の架け橋を目指して-2010

    • Author(s)
      福岡豊
    • Organizer
      第25回生体生理工学シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Presentation] Microarray analysis of mRNA expressions related to IL-6 in stretched normal human pulmonary artery endothelial cells2010

    • Author(s)
      小林こず恵, 田中真澄, 稲岡秀検, 根武谷吾, 福岡豊, 小林弘祐, 野城真理
    • Organizer
      第49回日本生体医工学会大会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of cyclic stretch on early response gene expressions in normal human pulmonary artery endothelial cells in vitro2010

    • Author(s)
      K Kobayasbi, M Tanaka, H Ina-oka, K Kokubo, S Nebuya, Y Fukuoka, H Kobayashi, M Noshiro
    • Organizer
      IEEE International Conference on Bioinfomatics & Biomedicine
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genome-wide DNA methylation analysis in tumor and normal tissues from lung squamous cell carcinoma and serous cystadeno-carcinoma2010

    • Author(s)
      H Inaoka, Y Fukuoka, M Noshiro
    • Organizer
      IEEE International Conference on Bioinfomatics & Biomedicine
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞がんにおけるmicroRNA発現量と近傍遺伝子発現量の関係2009

    • Author(s)
      岩村泰輔、福岡豊、内山孝憲、稲岡秀検、Mahmut Y、水島洋、田中真二、有井滋樹、野城真理、田中博、Kohane IS
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 大規模がん発現データにおける共発現解析2009

    • Author(s)
      稲岡秀検、福岡豊、野城真理
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Cytokine productions and gene expressions caused by mechanical stretching of normal human pulmonary artery endothelial cells2009

    • Author(s)
      Kobayashi K, Tanaka M, Inaoka H, Nebuya S, Fukuoka Y, Kobayashi H, Noshiro M
    • Organizer
      The 20th International Conference on Genome Informatics
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 大規模がん発現データにおける共発現解析2009

    • Author(s)
      稲岡秀検、福岡豊、野城真理
    • Organizer
      第48回生体医工学大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺胞上皮細胞の機械的伸展による形状変化の測定2009

    • Author(s)
      小林こず恵、岸亜由美、田中真澄、稲岡秀検、根武谷吾、福岡豊, ほか
    • Organizer
      第48回生体医工学大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺動脈内皮細胞の機械的伸展による形状変化の測定2009

    • Author(s)
      小林こず恵、岸亜由美、田中真澄、稲岡秀検、根武谷吾、福岡豊, ほか
    • Organizer
      第24回生体生理工学シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝細胞がんにおけるmicroRNA発現量と近傍遺伝子発現量の関係2009

    • Author(s)
      岩村泰輔、福岡豊、内山孝憲、稲岡秀検、Muhmut Y、水島洋, ほか
    • Organizer
      第32回分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Co-expression analysis in close physical proximity using tumor data2009

    • Author(s)
      稲岡秀検, 福岡豊, 野城真理
    • Organizer
      The 20th International Conference on Genome Informatics
    • Place of Presentation
      Yokohama
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝細胞がんにおけるmicroRNAと近傍の遺伝子の発現の関係2008

    • Author(s)
      福岡豊, 稲岡秀検査, 岩村泰輔, Y Mohmut, 水島洋ほか
    • Organizer
      BMB2008(第31回日本分子生物学会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 適応闇値による遺伝子発現解析2008

    • Author(s)
      稲岡秀検, 福岡豊, 野城真理
    • Organizer
      第23回生体・生理工学シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Adaptive threshold to detect biologically meaningfulchanges in microarray data2008

    • Author(s)
      Y Fukuoka, H Inaoka, M Noshiro
    • Organizer
      30th Annu. Intl. Conf. IEEE Eng. Med. Biol. Soc.
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-08-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝細胞がんにおけるmicroRNAと近傍の遺伝子の発現の関係2008

    • Author(s)
      福岡豊、稲岡秀検、岩村泰輔、Mahmut Y、水島洋、田中真二、有井滋樹、内山孝憲、野城真理、田中博、Kohane IS
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 適応閾値による遺伝子発現解析2008

    • Author(s)
      稲岡秀検、福岡豊、野城真理
    • Organizer
      第23回生体・生理工学シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Adaptive threshold to detect biologically meaningful changes in microarray data2008

    • Author(s)
      福岡豊, 稲岡秀検, 野城真理
    • Organizer
      30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 5708-5711
    • Place of Presentation
      Vancouver
    • Related Report
      2010 Final Research Report
  • [Book] 次世代創薬テクノロジー実践:インシリコ創薬の最前線(創薬に向けた生命情報の統合)遺伝子医学MOOK14第3章2009

    • Author(s)
      田中博
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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