The development of novel bioactive compounds from the nematocysts.

• Project/Area Number: 20510197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Tokyo University of Marine Science and Technology
• Principal Investigator: NAGAI Hiroshi Tokyo University of Marine Science and Technology, 海洋科学部, 教授 (50291026)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 生物活性物質 / 海洋天然物化学 / ウンバチイソギンチャク / 刺胞 / ポリペプチド / 遺伝子解析 / 質量分析 / トリプシンインヒビター / 刺胞動物 / アカクラゲ / 溶血活性 / フォスフォリパーゼA2 / リゾ型リン脂質 / ヒメイソギンチャク / タンパク質毒素 / アミノ酸・次配列 / 塩基配列

Research Abstract

The screening of the novel bioactive compounds were accomplished on some cnidarians and isolated nematocysts. We have succeeded in the isolation and characterization of some new bioactive proteins and small molecular weight compounds. A new actinoporin toxin was isolated and characterized from the sea anemone Anthopleura asiatica. Furthermore, a new Kunitz type protease inhibitor protein was characterized from the sea anemone Phyllodiscus semoni.

Research Products

• [Journal Article] Kazuhiro Irie Role of the phenolic hydroxyl group in the biological activities of simplyfied analogue of aplysiatoxin with antiproliferative activity. (2010)
  • Author(s): Ryo C. Yanagita, Hiroaki Kamachi, Keisuke Tanaka, Akira Murakami, Yu Nakagawa, Harukuni Tokuda, Hiroshi Nagai
  • Journal Title: Bioorganic & Medicinal Chemistry Letters. 20 Pages: 6064-6066
  • Peer Reviewed
• [Journal Article] Role of the phenolic hydroxyl group in the biological activities of simplyfied analogue of aplysiatoxin with antiproliferative activity. (2010)
  • Author(s): R.C.Yanagita, H.Kamachi, K.Tanaka, A.Murakami, Y.Nakagawa, H.Tokuda, H, Nagai, K.Irie
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 20 Pages: 6064-6066
  • Peer Reviewed
• [Journal Article] Characterization of a new hemolytic protein toxin from the sea anemone Anthopleura asiatica. (2009)
  • Author(s): Yuuki Kohno, Hiroshi Satoh, Akiko Iguchi, Hiroshi Nagai.
  • Journal Title: Fisheries Science 75 Pages: 1049-1054
  • NAID: 10024979800
  • Peer Reviewed
• [Journal Article] JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea. (2009)
  • Author(s): T. Fujiwara, J.H. Hwang, A. Kanamoto, H. Nagai, M. Takagi, K. Shin-Ya
  • Journal Title: Journal of Antibiotics 62 Pages: 393-395
  • NAID: 10030635826
  • Peer Reviewed
• [Journal Article] A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter : Development of a synthetically accessible protein kinase C activator with bryostatin-like activity. (2009)
  • Author(s): Yu Nakagawa, Ryo C. Yanagita, Naoko Hamada, Akira Murakami, Hideyuki Takahashi, Naoaki Saito, Hiroshi Nagai, Kazuhiro Irie.
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 7573-7579
  • Peer Reviewed
• [Journal Article] Structual characterizatio of plancitoxin I, a deoxyribonucleases II-like lethal factor from the crown-of-thorns starfich Acanthaster planci, by expression in Chinese hamster ovary cells. (2009)
  • Author(s): Ai Watanabe, Hiroshi Nagai, Yuji Nagashima, Kazuo Shiomi.
  • Journal Title: Fisheries Science 75 Pages: 225-331
  • Peer Reviewed
• [Journal Article] Isolation and cDNA cloning of an antibacterial L-amino acid oxidase from the skin mucus of the great sculpin Myoxochephalus polyacanthocephalus. (2009)
  • Author(s): Yuji Nagashima, Chihiro Tsukamoto, Yoichiro Kitani, Shoichiro Ishizaki, Hiroshi Nagai, Takashi Yanagimoto.
  • Journal Title: Comp.Biochem.Physiol. Part B 154 Pages: 55-61
  • Peer Reviewed
• [Journal Article] Characterization of a new hemolytic protein toxin from the sea anemone Anthopleura asiatica (2009)
  • Author(s): Yuuki Kohno, Hiroshi Satoh, Akiko Iguchi, Hiroshi Nagai
  • Journal Title: Fisheries Science 75 Pages: 1049-1054
  • NAID: 10024979800
  • Peer Reviewed
• [Journal Article] Isolation and cDNA cloning of an antibacterial L-amino acid oxidase from the skin mucus of the great sculpin Myoxocephalus polyacanthoce phalus (2009)
  • Author(s): Yuji Nagashima, Chihiro Tsukamoto, Yoichiro Kitani, Shoichiro Ishizaki, Hiroshi Nagai, Takashi Yanagimoto
  • Journal Title: Comparative Biochemistry and Physiology, Part B 154 Pages: 55-61
  • Peer Reviewed
• [Journal Article] Structural characterization of plancitoxin I, a deoxyribonucleases II-like lethal factor from the crown-of-thorns starfish Acanthaster planci, by expression in Chinese hamster ovary cells (2009)
  • Author(s): Ai Watanabe, Hiroshi Nagai, Yuji Nagashima A, Kazuo Shiomi
  • Journal Title: Fisheries Science 75 Pages: 225-331
  • NAID: 10024733840
  • Peer Reviewed
• [Journal Article] JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea (2009)
  • Author(s): Fujiwara T, Hwang JH, Kanamoto A, Nagai H, Takagi M, Shin-Ya K
  • Journal Title: J Antibiot (Tokyo) 62 Pages: 393-395
  • NAID: 10030635826
  • Peer Reviewed
• [Journal Article] A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter : Development of a synthetically accessible protein kinase C activator with bryostatin-like activity (2009)
  • Author(s): Yu Nakagawa, Ryo C.Yanagita, Naoko Hamada, Akira Murakami, Hideyuki Takahashi, Naoaki Saito, Hiroshi Nagai, Kazuhiro Irie
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 7573-7579
  • Peer Reviewed
• [Journal Article] アナサンゴモドキ(火炎サンゴ)のタンパク質毒素 (2009)
  • Author(s): 井口聡子, 永井宏史
  • Journal Title: 化学と生物 47 Pages: 524-526
• [Journal Article] 海洋危険生物に由来する蛋白質毒素の性状と機能 (2009)
  • Author(s): 永井宏史
  • Journal Title: 蛋白質核酸酵素 54 Pages: 621-627
• [Journal Article] 刺胞動物の持つタンパク質毒素 (2009)
  • Author(s): 永井宏史
  • Journal Title: 月刊海洋 463 Pages: 267-274
• [Journal Article] クラゲの毒 (2009)
  • Author(s): 永井宏史
  • Journal Title: 科学(岩波書店) 79 Pages: 395-397
• [Journal Article] Purification and Seaching for Bioactive Water-Soluble Compounds from Marine Sponges. (2008)
  • Author(s): Kosaku Ito, Atsushi Tsuruta, Keiji Takahara, Satoko Matayoshi, Hiroshi Nagai.
  • Journal Title: Proceedings of the WFC2008 (5th World Fisheries Congress) 3g-0678-483 (CD)
• [Journal Article] Purification and molecular cloning of SE-cephalotoxin, a novel proteinaceous toxin from the posterior salivary gland of cuttlefish Sepia esculenta. (2008)
  • Author(s): Atsushi Ueda, Hiroshi Nagai, Masami Ishida, Yuji Nagashima, Kazuo Shiomi.
  • Journal Title: Toxicon 52 Pages: 574-581
  • Peer Reviewed
• [Journal Article] Novel peptide toxins from the sea anemone Stichodactyla haddoni. (2008)
  • Author(s): T. Homma, S. Kawahata, M. Ishida, H. Nagai, Y. Nagashima, K. Shiomi.
  • Journal Title: Peptides 29 Pages: 536-554
• [Journal Article] Isolation and characterization of a novel protein toxin from fire coral. (2008)
  • Author(s): Akiko Iguchi, Setsuko Iwanaga, Hiroshi Nagai.
  • Journal Title: Biochem. Biophys. Res. Comuun. 365 Pages: 107-112
  • Peer Reviewed
• [Journal Article] Purification and molecular cloning of SE-cephalotoxin, a novel proteinaceous toxin from the posterior salivary gland of cuttlefish Sepia esculenta. (2008)
  • Author(s): Atsushi Ueda, Hiroshi Nagai. Masami Ishida, Yuji Nagashima, Kazuo Shiomi.
  • Journal Title: Toxicon 52 Pages: 574-581
  • Peer Reviewed
• [Journal Article] Novel peptide toxins from the sea anemone Stichodactyla haddoni. (2008)
  • Author(s): Tomohiro Honma, Shino Kawahata, Masami Ishida, Hiroshi Nagai, Yuji Nagashima, Kazuo Shiomi.
  • Journal Title: Peptides 29 Pages: 536-544
  • Peer Reviewed
• [Journal Article] Isolation and characterization of a novel protein toxin from fire coral. (2008)
  • Author(s): Akiko Iguchi, Setsuko Iwanaga, Hiroshi Nagai.
  • Journal Title: Biochem. Biophys. Res. Commun. 365 Pages: 107-112
  • Peer Reviewed
• [Presentation] Dinophysis属培養株による新規エステル型オカダ酸群の探索 (2011)
  • Author(s): 内田肇・菊次沙織・内田直行・神尾道也・永井宏史・永井敏・神山孝史・渡邊龍一・鈴木敏之
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学(東京)
  • Year and Date: 2011-03-29
• [Presentation] ハブクラゲ刺胞に局在する低分子化合物の探索 (2011)
  • Author(s): 北谷龍樹・内田肇・鈴木敏之・長島裕二・神尾道也・永井宏史
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学(東京)
  • Year and Date: 2011-03-28
• [Presentation] 深海クラゲの有するポリペプチド毒素の精製 (2011)
  • Author(s): 川端建徳・喜多村稔・Dhugal Lindsay・小西聡史・西川淳・西田周平・神尾道也・永井宏史
  • Organizer: Blue Earth 2011
  • Place of Presentation: 東京海洋大学(東京)
  • Year and Date: 2011-03-07
• [Presentation] Study on proteinaceous toxins from the scyphozoan jellyfishes (2010)
  • Author(s): T.Kawabata, M.Kitamura, D.Lindsay, S.Konishi, J.Nishikawa, S.Nishida, H.Nagai
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies.
  • Place of Presentation: Hawaii convention center,(ハワイ、アメリカ、国際学会)
  • Year and Date: 2010-12-20
• [Presentation] The compounds from the isolated nematocysts and tentacles of the deadly box jellyfish, Chironex yamaguchii (2010)
  • Author(s): R. Kitatani, T.Suzuki, H.Nagai
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies.
  • Place of Presentation: Hawaii convention center,(ハワイ、アメリカ、国際学会)
  • Year and Date: 2010-12-20
• [Presentation] Study on proteinaceous toxins from the scyphozoan jellyfishes (2010)
  • Author(s): T.Kawabata, M.Kitamura, D.Lindsay, S.Konishi, J.Nishikawa, S.Nishida, H.Nagai
  • Organizer: 2010 International Chemical Congress of PacificBasin Societies.
  • Place of Presentation: Hawaii Convention Center(ホノルル ハワイ U.S.A.)
  • Year and Date: 2010-12-20
• [Presentation] The compounds from the isolated nematocysts and tentacles of the deadly box jellyfish, Chironex yamaguchii (2010)
  • Author(s): R.Kitatani, T.Suzuki, H.Nagai
  • Organizer: 2010 International Chemical Congress of PacificBasin Societies
  • Place of Presentation: Hawaii Convention Center(ホノルル ハワイ U.S.A.)
  • Year and Date: 2010-12-20
• [Presentation] Marine natural toxins in Japan (2010)
  • Author(s): 永井宏史
  • Organizer: 2010Turkey-Japan Marine Forum.
  • Place of Presentation: Istanbul technical university(イスタンブール、トルコ、国際セミナー)
  • Year and Date: 2010-12-08
• [Presentation] Marine natural toxins in Japan (2010)
  • Author(s): Hiroshi Nagai
  • Organizer: 2010 Turkey-Japan Marine Forum
  • Place of Presentation: イスタンブール(イスタンブール トルコ)
  • Year and Date: 2010-12-08
• [Presentation] Proteinaceous toxins from the venomous marine animals (2010)
  • Author(s): 永井宏史
  • Organizer: 13th International Symposium on Marine Natural Products.
  • Place of Presentation: Hilton Phuket Arcadia Resort & Spa Hotel(プーケット、タイ、国際学会)
  • Year and Date: 2010-10-21
• [Presentation] Proteinaceous toxins from the venomous marine animals (2010)
  • Author(s): Hiroshi Nagai
  • Organizer: 13th International Symposium on Marine Natural Products
  • Place of Presentation: Hilton Phuket ArcadiaResort & Spa Hotel(プーケット タイ)(招待講演)
  • Year and Date: 2010-10-21
• [Presentation] 海洋危険生物のもつタンパク質毒素 (2010)
  • Author(s): 永井宏史
  • Organizer: 第57回トキシンシンポジウム
  • Place of Presentation: 長浜ロイヤルホテル(滋賀県長浜市)
  • Year and Date: 2010-07-16
• [Presentation] 海洋危険生物のもつタンパク質毒素 (2010)
  • Author(s): 永井宏史
  • Organizer: 第57回トキシンシンポジウム
  • Place of Presentation: 長浜ロイヤルホテル(滋賀)
  • Year and Date: 2010-07-16
• [Presentation] 刺胞動物の刺胞に由来する低分子化合物について (2010)
  • Author(s): 北谷龍樹・戸高匠・鈴木敏之・永井宏史
  • Organizer: 第24回海洋生物活性談話会
  • Place of Presentation: 国民休暇村大久野島(広島県竹原市)
  • Year and Date: 2010-06-05
• [Presentation] 刺胞動物の刺胞に由来する低分子化合物について (2010)
  • Author(s): 北谷龍樹・戸高匠・鈴木敏之・永井宏史
  • Organizer: 第24回海洋生物活性談話会
  • Place of Presentation: 国民休暇村大久野島(広島)
  • Year and Date: 2010-06-05
• [Presentation] アカクラゲ(Chrysaora melanaster)触手から得られた化合物とフォスフォリパーゼA2の関係 (2010)
  • Author(s): 戸高匠・藤原健史・永井宏史
  • Organizer: 2010年度日本水産学会春季大会
  • Place of Presentation: 日本大学生物資源科学部(藤沢、神奈川)
  • Year and Date: 2010-03-29
• [Presentation] 横浜市野島海岸の海洋生物が持つ生理活性物質に関する研究 (2010)
  • Author(s): 石田遥祐・周威・佐藤真耶・卜英悦・北谷龍樹・菅原孝太郎・永井宏史
  • Organizer: 2010年度日本水産学会春季大会
  • Place of Presentation: 日本大学生物資源科学部(藤沢、神奈川)
  • Year and Date: 2010-03-28
• [Presentation] The chemical study on small weight compounds from the deadly box jellyfish (2010)
  • Author(s): Ryuju Kitatani, Hiroshi Nagai
  • Organizer: JSPS-NRCT International symposium, JSPS Core University Program. Productivity techniques and effective utilization of aquatic animal resources to the new century.
  • Place of Presentation: 東京海洋大学(東京、国際学会)
  • Year and Date: 2010-02-26
• [Presentation] 横浜市野島海岸の海洋生物が持つ生理活性物質に関する研究 (2010)
  • Author(s): 石田遥祐・周威・佐藤真耶・卜英悦・北谷龍樹・菅原孝太郎・永井宏史
  • Organizer: 2010年度日本水産学会春季大会
  • Place of Presentation: 神奈川
• [Presentation] アカクラゲ(Chrysaora melanaster) 触手から得られた化合物とフォスフォリパーゼA2の関係 (2010)
  • Author(s): 戸高匠・藤原健史・永井宏史
  • Organizer: 2010年度日本水産学会春季大会
  • Place of Presentation: 神奈川
• [Presentation] The chemical study on small weight compounds from the deadly box jellyfish (2010)
  • Author(s): 北谷龍樹, 永井宏史
  • Organizer: JSPS-NRCT International symposium, JSPS Core University Program. Productivity techniques and effective utilization of aquatic animal resources to the new century
  • Place of Presentation: Tokyo
• [Presentation] Isolation and characterization of a new hemolytic protein toxin from the sea anemone (2009)
  • Author(s): 永井宏史
  • Organizer: JSPS-NRCT International symposium, Joint Seminar 2009 in Fisheries Science.
  • Place of Presentation: Novotel hotel(ラヨーン、タイ、国際学会)
  • Year and Date: 2009-12-14
• [Presentation] 沖縄の海洋危険生物の毒素 (2009)
  • Author(s): 永井宏史
  • Organizer: 平成21年度 沖縄沿岸海域エリア・都市エリア産学官連携促進事業 マリンバイオ産業創出シンポジウム
  • Place of Presentation: ロワジールホテル&スパタワー那覇(那覇)
  • Year and Date: 2009-12-03
• [Presentation] 沖縄の海洋危険生物の毒素 (2009)
  • Author(s): 永井宏史
  • Organizer: 平成21年度 沖縄沿岸海域エリア・都市エリア産学官連携促進事業 マリンバイオ産業創出シンポジウム
  • Place of Presentation: 那覇
  • Year and Date: 2009-12-03
• [Presentation] Study on the protein toxins from the deep-sea jellyfishes in Sagami bay. (2009)
  • Author(s): Takenori Kawabata, Hiroshi Nagai
  • Organizer: The 2009 international exchange seminar on the effective use of marine resources towards the future relationship between Japan and Turkey.
  • Place of Presentation: 東京海洋大学(東京、国際セミナー)
  • Year and Date: 2009-11-17
• [Presentation] The study on antibacterial substances from the egg mass of Bladder Moon snail Glossaulax didyma. (2009)
  • Author(s): Yosuke Ishida, Hiroshi Nagai
  • Organizer: 5^<th> Asia-Pacific Conference on Chemical Ecology.
  • Place of Presentation: Hilton Waikiki Prince Kuhio Hotel(ハワイ、アメリカ、国際学会)
  • Year and Date: 2009-10-28
• [Presentation] 神奈川県野島海浜に生息する生物からの生理活性物質の探索 (2009)
  • Author(s): 石田遥祐・佐藤真耶・永井宏史
  • Organizer: 第16回臨海研究若手の会
  • Place of Presentation: 筑波大学下田臨海実験センター(下田、静岡)
  • Year and Date: 2009-09-20
• [Presentation] アカクラゲ(Chrysaora melanaster)触手に含まれる低分子溶血活性物質に関する研究 (2009)
  • Author(s): 戸高匠・藤原健史・永井宏史
  • Organizer: 第16回臨海研究若手の会
  • Place of Presentation: 筑波大学下田臨海実験センター(下田、静岡)
  • Year and Date: 2009-09-20
• [Presentation] ハブクラゲ刺胞および触手に存在する低分子化合物に関する研究 (2009)
  • Author(s): 北谷龍樹・藤原健史・岩永節子・永井宏史
  • Organizer: 第12回マリンバイオテクノロジー学会大会
  • Place of Presentation: 早稲田大学理工学部(東京)
  • Year and Date: 2009-05-30
• [Presentation] アカクラゲおよびハブクラゲに由来する低分子化合物について (2009)
  • Author(s): 北谷龍樹、戸高匠、藤原健史、永井宏史
  • Organizer: 第23回海洋生物活性談話会
  • Place of Presentation: 東京大学三崎臨海実験所(三浦、神奈川)
  • Year and Date: 2009-05-23
• [Presentation] 海綿Spongia sp.に含まれる溶血活性タンパク質 (2009)
  • Author(s): 伊藤光作・鶴田敦・高原景滋・又吉聖子・永井宏史
  • Organizer: 2009年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学(東京)
  • Year and Date: 2009-03-30
• [Presentation] 深海クラゲAtolla属が持つ種間特異的ポリペプチドの化学的性状解析 (2009)
  • Author(s): 川端建徳・喜多村稔・Dhugal Lindsay・小西聡史・西川淳・西田周平・永井宏史
  • Organizer: Blue Earth 2009
  • Place of Presentation: 東京海洋大学(東京)
  • Year and Date: 2009-03-12
• [Presentation] Chemical study on natural products from the isolated nematocysts and tentacles of the deadly box jellyfish, Chiropsalmus quadrigatus (Habukurage) (2009)
  • Author(s): Ryuju Kitatani, Hiroshi Nagai
  • Organizer: Pacific Science Intercongress 2009.
  • Place of Presentation: Hilton Hotel Tahiti (タヒチ、国際学会)
  • Year and Date: 2009-03-05
• [Presentation] Study of the bioactive substances from deep-sea jellyfishes (2009)
  • Author(s): Takenori Kawabata, Minoru Kitamura, Dhugal J Lindsay, Satoshi Konishi, Jun Nishikawa, Shuhei Nishida, Hiroshi Nagai
  • Organizer: Pacific Science Intercongress 2009.
  • Place of Presentation: Hilton Hotel Tahiti(タヒチ、国際学会)
  • Year and Date: 2009-03-05
• [Presentation] ヒメイソギンチャクに由来する溶血活性タンパク質毒素の性状解析 (2009)
  • Author(s): 河野友希・佐藤寛・井口聡子・永井宏史
  • Organizer: 2009年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学(東京)
• [Presentation] Chemical study on natural products from the isolated nematocysts and tentacles of the deadly box jellyfish, Chiropsalmus quadrigatus (Habukurage) (2009)
  • Author(s): 北谷龍樹, 永井宏史
  • Organizer: Pacific Science Intercongress 2009
  • Place of Presentation: Tahiti
• [Presentation] Study of the bioactive substances from deep-sea jellyfishes (2009)
  • Author(s): Takenori Kawabata, Minoru Kitamura, Dhugal J Lindsay, Satoshi Konishi, Jun Nishikawa, Shuhei Nishida, Hiroshi Nagai
  • Organizer: Pacific Science Intercongress 2009
  • Place of Presentation: Tahiti
• [Presentation] Isolation and characterization of a new hemolytic protein toxin from the sea anemone Anthopleura asiatica (2009)
  • Author(s): 永井宏史
  • Organizer: JSPS-NRCT International symposium, Joint Seminar 2009 in Fisheries Science
  • Place of Presentation: Rayong, Thailand
• [Presentation] Study on the protein toxins from the deep-sea jellyfishes in Sagamibay (2009)
  • Author(s): Takenori Kawabata, Hiroshi Nagai
  • Organizer: The 2009 International Exchange Seminar on the effective use of marine resources towards the future relationship between Japan and Turkey
  • Place of Presentation: Tokyo
• [Presentation] The study on antibacterial substances from the egg mass of Bladder Moon snail Glossaulax didyma (2009)
  • Author(s): 石田遥祐, 永井宏史
  • Organizer: 5th Asia-Pacific Conference on Chemical Ecology
  • Place of Presentation: Honolulu, Hawaii
• [Presentation] アカクラゲ(Chrysaora melanaster) 触手に含まれる低分子溶血活性物質に関する研究 (2009)
  • Author(s): 戸高匠・藤原健史・永井宏史
  • Organizer: 第16回臨海研究若手の会
  • Place of Presentation: 静岡
• [Presentation] 神奈川県野島海浜に生息する生物からの生理活性物質の探索 (2009)
  • Author(s): 石田遥祐・佐藤真耶・永井宏史
  • Organizer: 第16回臨海研究若手の会
  • Place of Presentation: 静岡
• [Presentation] ハブクラゲ刺胞および触手に存在する低分子化合物に関する研究 (2009)
  • Author(s): 北谷龍樹・藤原健史・岩永節子・永井宏史
  • Organizer: 第12回マリンバイオテクノロジー学会大会
  • Place of Presentation: 東京
• [Presentation] アカクラゲおよびハブクラゲに由来する低分子化合物について (2009)
  • Author(s): 北谷龍樹, 戸高匠, 藤原健史, 永井宏史
  • Organizer: 第23回海洋生物活性談話会
  • Place of Presentation: 神奈川
• [Presentation] ヒメイソギンチャクに由来する溶血活性タンパク質毒素の性状解析 (2009)
  • Author(s): 河野友希, 佐藤 寛, 井口聡子, 永井宏史
  • Organizer: 2009年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] 海綿Spongia sp. に含まれる溶血活性タンパク質 (2009)
  • Author(s): 伊藤光作, 鶴田 敦, 高原景滋, 又吉聖子, 永井宏史
  • Organizer: 2009年度日本水産学会春季大会
  • Place of Presentation: 東京
• [Presentation] 深海クラゲAtolla属が持つ種間特異的ポリペプチドの化学的性状解析 (2009)
  • Author(s): 川端建徳, 喜多村稔, Dhugal J. Lindsay, 小西聡史, 西川淳, 西田周平, 永井宏史
  • Organizer: Blue Earth 2009
  • Place of Presentation: 東京
• [Presentation] study of the bioactive substances from deep-sea jellyfishes (2009)
  • Author(s): Takenori Kawabata, Minoru Kitamura, Dhugal J Lindsay, Satoshi Konishi, Jun Nishikawa, Shuhei Nishida, Hiroshi Nagai
  • Organizer: Pacific Science Intercongress 2009
  • Place of Presentation: Tahiti
• [Presentation] 海洋危険生物に由来するタンパク質毒素研究の新展開 (2008)
  • Author(s): 永井宏史
  • Organizer: シンポジウム「生体分子による生物間の攻撃と防御」
  • Place of Presentation: 東京大学農学部(東京)
  • Year and Date: 2008-11-08
• [Presentation] 海洋危険生物に由来するタンパク質毒素研究の新展開 (2008)
  • Author(s): 永井宏史
  • Organizer: シンポジウム「生体分子による生物間の攻撃と防御」
  • Place of Presentation: 東京
  • Year and Date: 2008-11-08
• [Presentation] Isolation and characterization of a new hemolytic protein from the sea anemone Anthopleura asiatica (2008)
  • Author(s): Yuuki Kohno, Hiroshi Sato, Akikazu Yasuda, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008.
  • Place of Presentation: パシフィコ横浜(横浜、国際学会)
  • Year and Date: 2008-10-22
• [Presentation] Bioactive screening of deep-sea jellyfish (2008)
  • Author(s): Takenori Kawabata, Minoru Kitamura, Dhugal J Lindsay, Satoshi Konishi, Jun Nishikawa, Shuhei Nishida, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008.
  • Place of Presentation: パシフィコ横浜(横浜、国際学会)
  • Year and Date: 2008-10-22
• [Presentation] Searching for bioactive water-soluble compounds from marine sponges (2008)
  • Author(s): Kosaku Ito, Atsushi Tsuruta, Keiji Takahara, Satoko Matayoshi, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008.
  • Place of Presentation: パシフィコ横浜(横浜、国際学会)
  • Year and Date: 2008-10-22
• [Presentation] Chemical study on natural products from the isolated nematocysts of the deadly box jellyfish, Chiropsalmus quadrigatus (Habukurage) (2008)
  • Author(s): Ryuju Kitatani, Takeshi Fujiwara, Setsuko Iwanaga, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008.
  • Place of Presentation: パシフィコ横浜(横浜、国際学会)
  • Year and Date: 2008-10-22
• [Presentation] Construction of the biological resource library from Okinawan coastal waters (2008)
  • Author(s): Takeshi Fujiwara, Akihiko Kanamoto, Hiroshi Nagai, Junichi Tanaka, Kazuo Shinya.
  • Organizer: World Fisheries Congress 2008.
  • Place of Presentation: パシフィコ横浜(横浜、国際学会)
  • Year and Date: 2008-10-22
• [Presentation] Toxins from the marine venomous animals (2008)
  • Author(s): 永井宏史
  • Organizer: University of Gothenburg and JSPS Stockholm Office Joint Seminar
  • Place of Presentation: Gothenburg University,(イェーテボリ、スウェーデン)
  • Year and Date: 2008-10-03
• [Presentation] Toxins from the marine venomous animals (2008)
  • Author(s): Hiroshi Nagai
  • Organizer: University of Gothenburg and JSPS Stockholm office Joint Seminar
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 2008-10-03
• [Presentation] 深海クラゲAtolla wyvilleiおよびA. banhoeffeniに存在する種間特異的ポリペプチド (2008)
  • Author(s): 川端建徳・喜多村稔・Dhugal Lindsay・小西聡史・西川淳・西田周平・永井宏史
  • Organizer: 第3回化学生態学研究会
  • Place of Presentation: 湯の川プリンスホテル(函館、北海道)
  • Year and Date: 2008-07-04
• [Presentation] 海洋生物のタンパク質毒素研究を通して見えかけてきたもの (2008)
  • Author(s): 永井宏史
  • Organizer: 第22回海洋生物活性談話会
  • Place of Presentation: 金沢大学理学部附属臨海実験所(能登、石川)
  • Year and Date: 2008-05-24
• [Presentation] 刺胞動物のもつタンパク質毒素 (2008)
  • Author(s): 永井宏史
  • Organizer: 東京大学海洋研究所共同利用研究集会 シンポジウム「我が国における刺胞動物研究」
  • Place of Presentation: 東京大学海洋研究所(東京)
• [Presentation] 刺胞動物のもつタンパク質毒素 (2008)
  • Author(s): 永井宏史
  • Organizer: シンポジウム「我が国における刺胞動物研究」東京大学海洋研究所共同利用研究集会
  • Place of Presentation: 東京
• [Presentation] Isolation and characterization of a new hemolytic protein from the sea anemone Anthopleura asiatica (2008)
  • Author(s): Yuuki Kohno, Hiroshi Sato, Akikazu Yasuda, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008
  • Place of Presentation: Yokohama Japan
• [Presentation] Bioactive screening of deep-sea jellyfish (2008)
  • Author(s): Takenori Kawabata, Minoru Kitamura, Dhugal J Lindsay, Satoshi Ronishi, Jun Nishikawa, Shuhei Nishida, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008
  • Place of Presentation: Yokohama Japan
• [Presentation] Searching for bioactive water-soluble compounds from marine Sponges (2008)
  • Author(s): Kosaku Ito, Atsushi Tsuruta, Keiji Takahara, Satoko Matayoshi, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008
  • Place of Presentation: Yokohama Japan
• [Presentation] Chemical study on natural products from the isolated nematocysts of the deadly box jellyfish, Chiropsalmus quadrigatus (Habukurage) (2008)
  • Author(s): Ryuju Kitatani, Takeshi Fujiwara, Setsuko Iwanaga, Hiroshi Nagai
  • Organizer: World Fisheries Congress 2008
  • Place of Presentation: Yokohama Japan
• [Presentation] Construction of the biological resource library from Okinawancoastal waters (2008)
  • Author(s): Takeshi Fujiwara, Akihiko Kanamoto, Hiroshi Nagai, Junichi Tanaka, Kazuo Shin-ya
  • Organizer: World Fisheries Congress 2008
  • Place of Presentation: Yokohama Japan
• [Presentation] 深海クラゲAttola wyvilleiおよびA. vanhoeffeniに存在する種間特異的ポリペプチド (2008)
  • Author(s): 川端建徳, 喜多村稔, Dhugal Lindsay, 小西聡史, 西川淳, 西田周平, 永井宏史
  • Organizer: 第3回化学生態学研究会
  • Place of Presentation: 函館
• [Presentation] 海洋生物のタンパク質毒素研究を通して見えかけてきたもの (2008)
  • Author(s): 永井宏史
  • Organizer: 第22回海洋生物活性談話会
  • Place of Presentation: 石川 能登
• [Book] タンパク質毒素 天然物化学-海洋生物編 山村庄亮、長谷川宏司、木越英夫編 (2008)
  • Author(s): 永井宏史(分担執筆)
  • Publisher: (株)アイピーシー
• [Remarks] ホームページ等
  • URL: http://www2.kaiyodai.ac.jp/~nagai/nagailabhomepage/index.html
• [Remarks]
  • URL: http://www2.kaiyodai.ac.jp/~nagai/nagailabhomepage/
• [Remarks]
  • URL: http://www2.kaiyodai.ac.jp/~nagai/nagailabhomepage/
• [Remarks]
  • URL: http://www2.kaiyodai.ac.jp/~nagai/nagailabhomepage/