| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
To determine the absolute stereochemistry of palau'amide we synthesized four possible diasteremers of palau'amide with regard to C37 and C38. Among the NMR spectra of the four synthetic diastereomers, that of 1 was identical to that of natural palau'amide. This established the complete stereostructure. SAR study of aurilide was carried out, and target biomolecule of aurilide was determined to be prohibitin in the mitochondria. Synthetic studies on miuraenamide have been carried out. Miuraenamide induces actin polymerization and stabilizes actin filament. In addition, isolation, structure determination, and synthetic studies of related compounds have been carried out.
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