| Project/Area Number |
20510205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
|
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| Research Institution | Musashino University |
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Principal Investigator |
ICHINOSE Koji Musashino University, 薬学研究所, 教授 (40282610)
|
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Takaaki 武蔵野大学, 薬学研究所, 講師 (80409383)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 抗生物質 / 生合成 / 放線菌 / フラビン酵 / 酸素添加 / フラビン酵素 / 酵素添加 |
|---|
| Research Abstract |
One of the key factors for medicinal developments is the structural diversity in the lead compounds. Our research has focused on the actinomycete bacteria, which produce most of the clinically important antibiotics, to reveal the function of a key biosynthetic enzyme leading to structural diversity. In this project, we characterized an oxygenase, ActVA-5/ActVB, for the actinorhodin biosynthesis in Streptomyces coelicolor A3 (2), to discover its quinine-forming activity, together with an additional enzymatic function as epoxyquinone formation.
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