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A study of the physiological psychology to investigate the brain mechanisms of the hyperactive and learning disorders using Tsukuba emotional strain rats as an animal model of these disorders.

Research Project

Project/Area Number 20530670
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionJin-ai University

Principal Investigator

YOSHIDA Kazunori  Jin-ai University, 人間学部, 教授 (50143938)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords生理 / 多動 / 学習障害モデル / 学習障害 / 多動障害 / 動物障害モデル / 脳内メカニズム / 海馬
Research Abstract

The present study was intended to clarify the brain mechanism of the hyperactivity and learning disorder, as well as to determine the appropriateness of Tsukuba low emotional strain (L strain) rats as an animal model of the hyperactive and learning disorder, by observing the general activity and various learning acquisition processes of these rats in detail. As a result, it revealed an interesting fact that the L strain rats showed a clear spatial learning disorder in the spatial learning problem with an 8-arm radial maze needing a working memory. In addition, peculiar circadian rhythm was observed in the L strain rats, and the validity of the hyperactive and learning disorder model of the L strain rats was confirmed. The morphological study mainly performed on the hippocampus which was important to spatial memory made very obvious that the volume ratio of the rostral part of the dorsal hippocampus for the whole hippocampus significantly decreased in the L strain rats, and that the volume ratio of the dentate gyrus for the dorsal hippocampus in these strain rats was quite lower compared with that in the other rats. Moreover, the findings displayed the negative correlation between the number of trials achieved in the spatial learning and the volume ratio of the dentate gyrus in the L strain rats. Therefore, the morphological transformation of the hippocampal dentate gyrus was suggested in terms of the spatial learning disorder.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 2008 Other

All Journal Article (5 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Tsukuba情動系ラットの空間学習成績と海馬内の神経構造との関連-飼育環境条件による影響について-2010

    • Author(s)
      吉田和典
    • Journal Title

      仁愛大学研究紀要 9

      Pages: 35-41

    • NAID

      110009468821

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tsukuba情動系ラットの空間学習成績と海馬内の神経構造との関連-飼育環境条件による影響について-2010

    • Author(s)
      吉田和典
    • Journal Title

      仁愛大学研究紀要

      Volume: 9 Pages: 35-41

    • NAID

      110009468821

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Tsukuba情動系ラットの概日リズムの特徴-輪回し行動による検討-2009

    • Author(s)
      吉田和典
    • Journal Title

      仁愛大学研究紀要 8

      Pages: 53-59

    • NAID

      110009468861

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Morris型水迷路によるTsukuba高・低情動系ラットの空間学習過程2008

    • Author(s)
      吉田和典
    • Journal Title

      人間学研究 7

      Pages: 87-94

    • NAID

      120005517200

    • Related Report
      2010 Final Research Report
  • [Journal Article] Morris型水迷路によるTsukuba高・低情動系ラットの空間学習過程2008

    • Author(s)
      吉田 和典
    • Journal Title

      人間学研究 7

      Pages: 87-94

    • NAID

      120005517200

    • Related Report
      2008 Annual Research Report
  • [Presentation] Tsukuba情動系ラットの輪回し行動によるサーカディアンリズムの特徴2010

    • Author(s)
      吉田和典
    • Organizer
      第28回日本生理心理学会
    • Place of Presentation
      茨城大学(茨城県)
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Tsukuba情動系ラットの輪回し行動によるサーカディアンリズムの特徴2010

    • Author(s)
      吉田和典
    • Organizer
      第28回日本生理心理学会大会
    • Related Report
      2010 Final Research Report
  • [Presentation] モーリス水迷路を用いたTsukuba情動系ラットの空間学習過程2009

    • Author(s)
      吉田和典
    • Organizer
      第27回日本生理心理学会
    • Place of Presentation
      同志社大学
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tsukuba低情動系ラットにおける行動抑制の検討-DRLスケジュールを用いて-2009

    • Author(s)
      木村誠,吉田和典
    • Organizer
      第69回日本動物心理学会大会
    • Related Report
      2010 Final Research Report
  • [Presentation] モーリス水迷路を用いたTsukuba情動系ラットの空間学習過程2009

    • Author(s)
      吉田和典
    • Organizer
      第27回日本生理心理学会大会
    • Related Report
      2010 Final Research Report
  • [Presentation] Tsukuba情動系ラットの海馬機能について2008

    • Author(s)
      吉田 和典
    • Organizer
      第26回日本生理心理学会
    • Place of Presentation
      琉球大学
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tsukuba情動系ラットの海馬機能について2008

    • Author(s)
      吉田和典
    • Organizer
      第26回日本生理心理学会大会
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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