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Development of Mineral-medicated Hydrothermal Flow Reactor and its Application to the Analysis of Chemical Evolution of Peptides

Research Project

Project/Area Number 20540476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Geochemistry/Astrochemistry
Research InstitutionOsaka Prefecture University

Principal Investigator

KAWAMURA Kunio  Osaka Prefecture University, 工学研究科, 助教 (50204772)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords宇宙科学 / 地球化学 / 化学進化 / 分析化学 / 生体分子 / 鉱物 / ペプチド / アミノ酸 / リアルタイム分析 / 生命の起源 / 熱水噴出孔 / 高温水 / 反応速度論
Research Abstract

It is considered that a first living organisms had been emerged under hydrothermal conditions on the primitive earth. However, the mechanism how biologically important organic compounds, such as proteins, had formed under such conditions was not clearly described. Here, the hydrothermal flow reactor technology, which was established in our group, was improved and a new monitoring method was successfully developed for simulating the hydrothermal vent system as a realistic model. By using this method, the activities of naturally occurring minerals for the peptide formation reaction, which was discovered in our group at 2005, were analyzed and we found the fact that carbonate minerals possess enhancement activities for the peptide formation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (56 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (35 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 生命起源の解明をめざした熱水フローリアクターシステムの開発2011

    • Author(s)
      川村邦男
    • Journal Title

      ぶんせき 2

      Pages: 104-107

    • NAID

      10027906715

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生命起源の解明をめざした熱水フローリアクターシステムの開発2011

    • Author(s)
      川村邦男
    • Journal Title

      ぶんせき

      Pages: 104-107

    • NAID

      10027906715

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innovations of hydrothermal flow reactors for the chemical evolution on primitive earth : the next step for the experimental evaluation of life-like systems2010

    • Author(s)
      川村邦男
    • Journal Title

      Viva Origino 37 in press

    • NAID

      110008672761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temperature limit for the emergence of life-like system deduced from the prebiotic chemical kinetics under the hydrothermal conditions2010

    • Author(s)
      川村邦男
    • Journal Title

      Proceedings of the Twelfth International Conference on the Simulation and Synthesis of Living Systems (Edited by, H. Fellermann, M. Dorr, M.M. Hanczyc, L.L. Lauren, S. Maurer, D. Merkle, P.-A. Monnard, K. Stoy, S. Rasmussen)

      Pages: 37-44

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ analysis of proteins at high temperatures mediated by capillary-flow hydrothermal UV-Vis spectrophotometer with a water-soluble chromogenic reagent, Anal.2010

    • Author(s)
      Kunio Kawamura, Hiroki Nagayoshi, Toshio Yao
    • Journal Title

      Chim.Acta 667

      Pages: 88-95

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ analysis of proteins at high temperatures mediated by capillary-flow hydrothermal UV-Vis spectrophotometer with a water-soluble chromogenic reagent2010

    • Author(s)
      Kunio Kawamura, Hiroki Nagayoshi, Toshio Yao
    • Journal Title

      Analytica Chimica Acta

      Volume: 667 Pages: 88-95

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature limit for the emergence of life-like system deduced from the prebiotic chemical kinetics under the hydrothermal conditions2010

    • Author(s)
      Kunio Kawamura
    • Journal Title

      Proceedings of the Twelfth International Conferenceon the Simulation and Synthesis of Living Systems

      Pages: 37-44

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innovations of hydrothermal flow reactors for the chemical evolution on primitive earth : the next step for the experimental evaluation of life-like systems2010

    • Author(s)
      Kunio Kawamura
    • Journal Title

      Viva Origino

      Volume: 37(印刷中)

    • NAID

      110008672761

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前生物的化学に基づいてRNAワールド仮説を検証する2009

    • Author(s)
      川村邦男
    • Journal Title

      Viva Origino 37

      Pages: 31-42

    • NAID

      110007651038

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stability of ribonuclease A under hydrothermal conditions in relation to the origin-of-life hypothesis : Verification with the hydrothermal micro-flow reactor system2009

    • Author(s)
      Kunio Kawamura, Hiroki Nagayoshi, Toshio Yao
    • Journal Title

      Research on Chemical Intermediates 35

      Pages: 879-891

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of condensation agents and minerals for oligopeptide formation under mild and hydrothermal conditions in related to chemical evolution of proteins2009

    • Author(s)
      Kunio Kawamura, Hitoshi Takeya, Takao Kushibe
    • Journal Title

      Advances in Space Research 44

      Pages: 267-275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stability of ribonuclease A under hydrothermal conditions in relation to the origin-of-life hypothesis : Verification with the hydrothermal micro-flow reactor system.2009

    • Author(s)
      Kunio Kawamura, Hiroki Nagayoshi, Toshio Yao
    • Journal Title

      Research on Chemical Intermediates 35

      Pages: 879-891

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of condensation agents and minerals for oligopeptide formation under mild and hydrothermal conditions in related to chemical evolution of proteins.2009

    • Author(s)
      Kunio Kawamura, Hitoshi Takeya, Takao Kushibe
    • Journal Title

      Advances in Space Research 44

      Pages: 267-275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stability of ribonuclease A under hydrothermal conditions in relation to the origin-of-life hypothesis : Verification with the hydrothermal micro-flow reactor system.2009

    • Author(s)
      Kunio Kawamura, Hiroki Nagayoshi, Toshio Yao
    • Journal Title

      Research on Chemical Intermediates

      Volume: (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of condensation agents and minerals for oligopeptide formation under mild and hydrothermal conditions in related to chemical evolution of proteins.2009

    • Author(s)
      Kunio Kawamura, Hitoshi Takeya, Takao Kushibe
    • Journal Title

      Advances in Space Research

      Volume: (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics and activation parameter analysis for the prebiotic oligocytidylate formation on Na^+-montmorillonite at 0-100℃2008

    • Author(s)
      Kunio Kawamura, Jun Maeda
    • Journal Title

      J.Phys.Chem.A 112

      Pages: 8015-8023

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-step formation of oligopeptide-like molecules from Glu and Asp in hydrothermal environments2008

    • Author(s)
      Kunio Kawamura, Masanori Shimahashi
    • Journal Title

      Naturwissenschaften 95

      Pages: 449-454

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Development of micro-flow analytical techniques for hydrothermal reactions2010

    • Author(s)
      Kunio Kawamura, Keisuke Ikoma, Tomoko Yasuda, Hiroki Nagayoshi, Hitoshi Takeya, Shukuro Igarashi, Hideaki Hisamoto, Toshio Yao
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies (Pachifichem 2010)
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2010 Final Research Report
  • [Presentation] Temperature limit for the emergence of life-like system deduced from the prebiotic chemical kinetics under the hydrothermal conditions2010

    • Author(s)
      川村邦男
    • Organizer
      Artificial Life 12
    • Place of Presentation
      Odense, Denmark
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemical evolution of life-like system under hydrothermal environments : prebiotic formation, degradation, and functions regarding protein-like molecules and RNA2010

    • Author(s)
      川村邦男
    • Organizer
      COSPAR Scientific Assembly 2010
    • Place of Presentation
      Bremen, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱水分析技術の開発と化学進化研究への展開2010

    • Author(s)
      川村邦男
    • Organizer
      生命の起原および進化学会第35回学術講演会
    • Place of Presentation
      函館(依頼シンポジウム講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 生命の定義と化学進化研究に基づいてリアルな原始生命体を描く2010

    • Author(s)
      川村邦男
    • Organizer
      国際高等研究所フェロー(池原)研究会「生命の本質-遺伝子、遺伝暗号、タンパク質および生命の起源」
    • Place of Presentation
      木津川(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of real-time and in situ UV-visible monitoring methods for hydrothermal reactions and its applications to the origin of life study2010

    • Author(s)
      Kunio Kawamura
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      ホノルル(ハワイ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of micro-flow analytical techniques for hydrothermal reactions2010

    • Author(s)
      Kunio Kawamura, Keisuke Ikoma, Tomoko Yasuda, Hiroki Nagayoshi, Hitoshi Takeya, Shukuro Igarashi, Hideaki Hisamoto, Toshio Yao
    • Organizer
      The 2010 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      ホノルル(ハワイ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱水フローリアクター反応の迅速モニタリング電気泳動チップデバイスの開発2010

    • Author(s)
      船内直樹・川村邦男・久本秀明
    • Organizer
      東京コンファレンス
    • Place of Presentation
      幕張(千葉)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高温高圧液相UV-VIS-NIR吸光光度法の開発とバイオマス処理過程のその場分析東京コンファレンス2010

    • Author(s)
      安田知子・畑中翼・中村薫・松田奈美・濱比嘉一泰・久本秀明・川村邦男・仲井和之
    • Organizer
      東京コンファレンス
    • Place of Presentation
      幕張(千葉)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temperature limit for the emergence of life-like system deduced from the prebiotic chemical kinetics under the hydrothermal conditions2010

    • Author(s)
      Kunio Kawamura
    • Organizer
      Artificial Life 12
    • Place of Presentation
      オーデンセ(デンマーク)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemical evolution of life-like system under hydrothermal environments : prebiotic formation, degradation, and functions regarding protein-like molecules and RNA2010

    • Author(s)
      Kunio Kawamura
    • Organizer
      COSPAR Scientific Assembly 2010
    • Place of Presentation
      ブレーメン(ドイツ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱水フローリアクターを利用する超微量イリジウムのフローインジェクション分析法2010

    • Author(s)
      生駒佳祐・久本秀明・八尾俊男・五十嵐淑郎・川村邦男
    • Organizer
      第71回分析化学討論会
    • Place of Presentation
      松江(島根)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hydrothermal reactor system for the flow injection analysis of trace metalions2010

    • Author(s)
      Kunio Kawamura, Keisuke Ikoma, Shukuro Igarashi, Hideaki Hisamoto, Toshio Yao
    • Organizer
      16th International Conference on Flow Injection Analysis
    • Place of Presentation
      パタヤ(タイ)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生命の定義と化学進化研究に基づいてリアルな原始生命体を描く2010

    • Author(s)
      川村邦男
    • Organizer
      国際高等研究所フェロー(池原)研究会
    • Place of Presentation
      国際高等研究所(木津川市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 熱水分析技術の開発と化学進化研究への展開2010

    • Author(s)
      川村邦男
    • Organizer
      生命の起原および進化学会第35回学術講演会
    • Place of Presentation
      公立はこだて未来大学(函館市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高温高圧溶液反応を用いたリアルタイム高速分析法の開発2009

    • Author(s)
      生駒佳祐, 安田知子, 八尾俊男, 川村邦男
    • Organizer
      第48回フローインジェクション分析講演会
    • Place of Presentation
      大阪府立大学(堺市)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] In situ monitoring of fast chemical processes under the hydrothermal conditions2009

    • Author(s)
      Yasuda Tomoko, Hiroki Nagayoshi, Toshio Yao, Kunio Kawamura^1
    • Organizer
      2009年日中分析化学研究会
    • Place of Presentation
      幕張メッセ(幕張)
    • Year and Date
      2009-09-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質の化学進化と生命の熱水起原2009

    • Author(s)
      川村邦男
    • Organizer
      国際高等研究所フェロー(池原)研究会「生命の本質-遺伝子、遺伝暗号、タンパク質および生命の起源」
    • Place of Presentation
      木津川(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 生命らしさからみるRNAワールド2009

    • Author(s)
      川村邦男
    • Organizer
      国際高等研究所フェロー(池原)研究会「生命の本質-遺伝子、遺伝暗号、タンパク質および生命の起源」
    • Place of Presentation
      木津川(招待講演)
    • Related Report
      2010 Final Research Report
  • [Presentation] 原始地球環境におけるオリゴペプチド生成反応に対する縮合剤および鉱物の影響2009

    • Author(s)
      川村邦男・竹家均・櫛部崇夫
    • Organizer
      2009年度日本地球化学会年会
    • Place of Presentation
      東広島
    • Related Report
      2010 Final Research Report
  • [Presentation] 高温高圧マイクロフローUV-vis吸光光度法の開発:ベンジルアルコール酸化反応の追跡2009

    • Author(s)
      安田知子, 川村邦男, 八尾俊男
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      和歌山大学(和歌山市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高温高圧溶液反応のリアルタイム高速分析法の展開2009

    • Author(s)
      安田知子, 永吉広樹, 竹家均, 八尾俊男, 川村邦男
    • Organizer
      東京コンファレンス
    • Place of Presentation
      幕張メッセ(幕張)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 原始地球環境におけるオリゴペプチド生成反応に対する縮合剤および鉱物の影響2009

    • Author(s)
      川村邦男, 竹家均, 櫛部崇夫
    • Organizer
      2009年度日本地球化学会年会
    • Place of Presentation
      広島大学(東広島市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生命らしさからみるRNAワールド2009

    • Author(s)
      川村邦男
    • Organizer
      国際高等研究所フェロー(池原)研究会
    • Place of Presentation
      国際高等研究所(木津川市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質の化学進化と生命の熱水起原2009

    • Author(s)
      川村邦男
    • Organizer
      国際高等研究所フェロー(池原)研究会
    • Place of Presentation
      国際高等研究所(木津川市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前生物的化学に基づいてRNAワールド仮説を検証する2009

    • Author(s)
      川村邦男
    • Organizer
      生命の起原および進化学会第34回学術講演会
    • Place of Presentation
      熊取(大阪)(依頼シンポジウム講演)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 化学の冒険:生命の起源への挑戦2008

    • Author(s)
      川村邦男
    • Organizer
      第201回自然環境論セミナー
    • Place of Presentation
      神戸大学(神戸)(招待講演)
    • Year and Date
      2008-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 化学の冒険:生命の起源への挑戦2008

    • Author(s)
      川村邦男
    • Organizer
      第201回自然環境論セミナー
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロフロー高温高圧液相反応分析法の展開:オリゴペプチドの水熱合成2008

    • Author(s)
      竹家均・川村邦男・八尾俊男
    • Organizer
      Separation Sciences 2008(分離と検出の科学)
    • Place of Presentation
      野田
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱水マイクロフローリアクターを用いるオリゴペプチドの非生物的生成反応の速度解析2008

    • Author(s)
      川村邦男・竹家均・嶋橋政徳・秋吉藍・西輝之・崎山智文
    • Organizer
      2008年度日本地球化学会年会
    • Place of Presentation
      東京(依頼講演)
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Ai Akiyoshi, Masanori Shimahashi, Oligopeptide formation under hydrothermal conditions using a micro-flow hydrothermal reactor2008

    • Author(s)
      川村邦男, 竹家均
    • Organizer
      15th International Conference on the Origin of Life : 12th ISSOL meeting
    • Place of Presentation
      Florence, Italy
    • Related Report
      2010 Final Research Report
  • [Presentation] Oligopeptide formation under hydrothermal conditions using a micro-flow hydrothermal reactor.2008

    • Author(s)
      K.Kawamura, H.Takeya, A.Akiyoshi, M.Shimahashi
    • Organizer
      15th International Conference on the Origin of Life
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] An RNA world under hydrothermal environments on the basis of kinetic analyses of the prebiotic formation of RNA.2008

    • Author(s)
      K.Kawamura, J.Maeda, H.Nagayoshi
    • Organizer
      15th International Conference on the Origin of Life
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高温溶液用UV-vis吸光光度法の開発と生体分子挙動の観測, 日本分析化学会第57年会2008

    • Author(s)
      川村邦男, 永吉広樹, 八尾俊男
    • Organizer
      日本分析化学会第57年会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] マイクロフロー高温高圧液相反応分析法の展開:オリゴペプチドの水熱合成2008

    • Author(s)
      竹家均, 川村邦男, 八尾俊男
    • Organizer
      Separation Sciences 2008 (分離と検出の科学)
    • Place of Presentation
      野田(千葉)
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.osakafu-u.ac.jp/ohka/ohka1/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.chem.osakafu-u.ac.jp/ohka/ohkal/kawamura/kawamuramain.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 固体充填フロー型高温高圧液相反応装置およびオリゴペプチドの合成法2010

    • Inventor(s)
      川村邦男
    • Industrial Property Rights Holder
      大阪府立大学
    • Industrial Property Number
      2010-021576
    • Filing Date
      2010-02-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Patent(Industrial Property Rights)] オリゴペプチドの製造方法2009

    • Inventor(s)
      川村邦男
    • Industrial Property Rights Holder
      大阪府立大学
    • Industrial Property Number
      2009-248365
    • Filing Date
      2009-10-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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