| Project/Area Number |
20550043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
NISHIHARA Yasushi (2010) 岡山大学, 大学院・自然科学研究科, 教授 (20282858)
高木 謙太郎 (2008-2009) Okayama University, 大学院・自然科学研究科, 教授 (80033405)
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| Co-Investigator(Kenkyū-buntansha) |
HANAYA Tadashi 岡山大学, 大学院・自然科学研究科, 准教授 (70189588)
SUEISHI Yoshimi 岡山大学, 大学院・自然科学研究科, 准教授 (50135935)
西原 康師 岡山大学, 大学院・自然科学研究科, 准教授 (20282858)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ロジウム / クロスカップリング / アリール亜鉛化合物 / アルキル求電子剤 / カルボニル化 / 酸化的Mizoroki-Heck反応 / 三成分連結反応 / ロジウム触媒 / 挿入 / 一酸化炭素 / アルケン / アルキル-アリールクロスカップリング / 三脚型配位子 / アルキルーアリールクロスカップリング / ホスホリル基 |
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| Research Abstract |
Catalytic cross-coupling between carbon electrophiles andorganometallic nucleophiles is one of the most useful method to construct carbon-carbonbonds in organic synthesis. In this research, group 9 metals were used as the catalyst in place of conventional group 10 metals like nickel and palladium, intending to open new areas of cross-coupling.
As the results, two methods were developed, where, by the catalysis with rhodium, otherwise difficult cross-couplings between alkyl electrophiles and arylzinc nucleophiles successfully take place. The Rh catalysts also achieved unprecedented cross-couplingreactions between arylzinc compounds and unsaturated molecules like carbon monoxideand alkenes by the assistance of oxidants.
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