| Project/Area Number |
20550071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Utsunomiya University |
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Principal Investigator |
UEHARA Nobuo Utsunomiya University, 工学研究科, 准教授 (50203469)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHITA Takashi 上智大学, 理工学部, 教授 (70183564)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 金ナノ粒子 / 化学センサー / バイオ分析 / チオール化合物 / 色彩計測 / グルタチオン / ドラッグデリバリー / ナノマテリアル / センサー |
|---|
| Research Abstract |
Thermoresponsive gold nanocomposites have been fabricated by conjunction of gold nanoparticles with thermoresponsive polymers and their colorimetric functions to sense sulfhydryl compounds have been also examined. The thermoresponsive gold nanocomposites exhibit disassembly by thermal stimuli, heating followed by cooling. Cysteine and homocysteine, sulfhydryl monopeptide, inhibit the disassembly while cysteinylglycine, sulfhydryl dipeptide, and glutathione, sulfhydryl tripeptides, promote the disassembly. Colorimetric quantification methods of cysteine, glutathione andγ-GPT are exploited based on the inhibition and promotion of the disassembly.
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