Practical Asymmetric Alkylation of Aldehydes by Using Grignard Reagents
| Project/Area Number |
20550095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
HARADA Toshiro Kyoto Institute of Technology, 工芸科学研究科, 教授 (30135628)
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| Co-Investigator(Kenkyū-buntansha) |
KUSUKAWA Takahiro 京都工芸繊維大学, 工芸科学研究科, 准教授 (70300720)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 合成化学 / 触媒・化学プロセス / 有機化学 / 有機金属化合物 / マグネシウム / 不斉合成 |
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| Research Abstract |
A practical catalytic method has been developed for the enantioselective synthesis of optically active secondary alcohols by using Grignard reagents in the reaction of aldehydes. A mixed titanium reagents derived from Grignard reagents and a titanium alkoxide undergo smooth addition to various aldehydes in the presence of a chiral titanium catalyst (2mol%) to give the corresponding optically active alcohols in high yields and in high enantioselectivities.
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Report
(4 results)
Research Products
(38 results)
