| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Mannich reaction between tosylimines and ketones smoothly took place in the presence of chiral silicon enolates, which were catalytically generated from the reaction of chiral Lewis acids with ketones, giving the corresponding Mannich adducts with moderate enantiomeric excess. In the presence of silicon Lewis acid catalysis,β,γ-unsaturatedγ-ractams react with tosylimines to afford 4, 5-disubstitutedγ-lactam in moderate yields. The most striking characteristic of this reaction is high atom economy.
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