| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The efficient synthetic routes to a series of hydroxy-amide-functionalized azolium salts such as azolium iodides and chlorides from chiral β-amino alcohols have been developed. For coordination of the azolium compound as NHC to palladium, the strategy based on the ligand transfer with the aid of a NHC-Ag complex intermediate was employed. Thus, a wide variety of NHC-Pd complexes have been successfully synthesized. The detail of the molecular structures of these NHC-Pd complexes was established by single-crystal X-ray diffraction studies. A chiral dimeric tridentate alkoxy/amidate/NHC palladium(II) complex effected oxidative Heck-type reactions of aryl boronic acids with acyclic alkenes at room temperature to afford the corresponding coupling products with high enantioselectivities.
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