Synthesis of a new metal complex bearing N-heterocyclic carbenes and its application to catalytic asymmetric reaction
| Project/Area Number |
20550103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kansai University |
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Principal Investigator |
SAKAGUCHI Satoshi Kansai University, 化学生命工学部, 准教授 (50278602)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 錯体 / 有機金属触媒 / 不斉合成反応 / 配位子デザイン / 含窒素複素環式カルベン / パラジウム錯体 / 酸化的Heck型反応 / 遷移金属触媒反応 / 不斉触媒反応 / アニオン性アミデート錯体 / 配位化学 / 酸化的Heck反応 / 不斉共役付加反応 / 立体選択性の逆転 / アニオン性アミデートPd錯体 / β-アミノアルコール / カルベンAg錯体 / アゾリウム塩 |
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| Research Abstract |
The efficient synthetic routes to a series of hydroxy-amide-functionalized azolium salts such as azolium iodides and chlorides from chiral β-amino alcohols have been developed. For coordination of the azolium compound as NHC to palladium, the strategy based on the ligand transfer with the aid of a NHC-Ag complex intermediate was employed. Thus, a wide variety of NHC-Pd complexes have been successfully synthesized. The detail of the molecular structures of these NHC-Pd complexes was established by single-crystal X-ray diffraction studies. A chiral dimeric tridentate alkoxy/amidate/NHC palladium(II) complex effected oxidative Heck-type reactions of aryl boronic acids with acyclic alkenes at room temperature to afford the corresponding coupling products with high enantioselectivities.
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Report
(4 results)
Research Products
(66 results)
