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Preparation of hydrophilic reactive biocompatible surface of amphiphilic block copolymer

Research Project

Project/Area Number 20550108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer chemistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

ISHIZONE Takashi  Tokyo Institute of Technology, 大学院・理工学研究科, 准教授 (60212883)

Co-Investigator(Renkei-kenkyūsha) YOKOYAMA Hideaki  東京大学, 新領域創成科学研究科, 准教授 (80358316)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords高分子合成 / 両親媒性ブロック共重合体 / 水溶性ポリマー / 感温性ポリマー / 側鎖末端基 / メタクリル酸トリ(エチレングリコール)ビニルエーテル / リビングアニオン重合 / ポリ(メタクリル酸トリエチレングリコール / ポリ(メタクリル酸トリエチレングリコール)
Research Abstract

A series of new amphiphilic block copolymers composed of water-soluble polymethacrylate and hydrophobic polystyrene was synthesized by the living anionic polymerization. Novel polymer surface showing hydrophilicity, reactivity, and biocompatibility was obtained by casting the block copolymer solution. The hydrophobic alkyl terminal groups in the side chains of polymethacrylate played important roles to achieve the surface segregation of water-soluble polymethacrylate segments.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (50 results)

All 2011 2010 2009 2008

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (15 results) Book (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Synthesis of Water-Soluble Poly[oligo(ethylene glycol) methacrylatels by Living Anionic Polymerization of Oligo(ethylene glycol) Vinyl Ether Methacrylates2011

    • Author(s)
      J.Yamanaka, T.Kayasuga, M.Ito, H.Yokoyama, T.Ishizone
    • Journal Title

      Polym.Chem. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Precise synthesis of thermo-responsive and water-soluble star-branched polymers and star bloc copolymers by living anionic polymerization.2011

    • Author(s)
      A.Hirao, R.Inushima, T.Nakayama, T.Watanabe, H.-S.Yoo, T.Ishizone, K.Sugiyama, T.Kakuchi, S.Carlotti, A.
    • Journal Title

      Deffieux Eur.Polym.J. 47

      Pages: 713-722

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Precise synthesis of thermo-responsive and water-soluble star-branched polymers and star block copolymers by living anionic polymerization2011

    • Author(s)
      Akira Hirao, Reiko Inushima, Takefumi Nakayama, Takumi Watanabe, Hee-Soo Yoo, Takashi Ishizone, Kenji Sugiyama, Toyoji Kakuchi, Stephane Carlotti, Alain Deffieux
    • Journal Title

      Eur.Polym.J.

      Volume: 47 Pages: 713-722

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal orientation of Poly(E-caprolactone) Homopolymers Confined in Cylindrical Nanodomains2010

    • Author(s)
      S.Nojima, Y.Oguma, K.Kadena, T.Ishizone, Y.Iwasaki, K.Yamaguchi
    • Journal Title

      Macromolecules 43

      Pages: 3916-3923

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of N-Methacryloylazetidine : Anionic Polymerizability of N, N-Dialkylmethacrylamides2010

    • Author(s)
      T.Suzuki, J.Kusakabe, K.Kitazawa, T.Nakagawa, S.Kawauchi, T.Ishizone
    • Journal Title

      Macromolecules 43

      Pages: 107-116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of N-Methacryloylazetidine : Anionic Polymerizability of N, N-Dialkylmethacrylamides2010

    • Author(s)
      Takashi Suzuki, Jun-ichi Kusakabe, Keita Kitazawa, Susumu Kawauchi, Takashi Ishizone
    • Journal Title

      Macromolecules

      Volume: 43 Pages: 107-116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal Orientation of Poly (ε-caprolactone) Homopolymers Confined in Cylindrical Nanodomaines2010

    • Author(s)
      Shuichi Nojima, Yuya Ohguma, Ken-ichi Kadena, Takashi Ishizone, Yuta Iwasaki, Kazuo Yamaquchi
    • Journal Title

      Macromolecules

      Volume: 43 Pages: 3916-3923

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Well-Defined Poly(ethylene-alt-1-vinyladamantane) via Living Anionic Polymerization of 2-(1-Adamantyl)-1, 3-butadiene, Followed by Hydrogenation2009

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone
    • Journal Title

      Macromolecules 42

      Pages: 5017-5026

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two Dimentional Nano-dot Array Engineering of Block Copolymer Surface Micelles on Water Surface2009

    • Author(s)
      S.Nagano, Y.Matsushita, S.Shinma, T.Ishizone, T.Seki
    • Journal Title

      Thin Solid Films 518

      Pages: 724-728

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of Styrenes Containing Adamantyl Skeletons2009

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone
    • Journal Title

      Journal of Physics : Conference Series 184

      Pages: 12017-12017

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Well-defined Random and Block Copolymers of 2-(1-Adamantyl)-1,3-butadiene with Isoprene via Anionic Polymerization2009

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone, T.Kato, T.Ono, S.Kubotaka, K.Arimoto, H.Ogi
    • Journal Title

      Reactive and Functional Polymers 69

      Pages: 409-415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of 11-Methacryloy1-2-methylaziridine2009

    • Author(s)
      T.Ishizone, J.Kusakabe, T.Suzuki
    • Journal Title

      Macromolecular Symposia 279

      Pages: 21-28

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アダマンタン骨格を有する高分子の精密合成2009

    • Author(s)
      石曽根隆
    • Journal Title

      有機合成化学協会誌 67

      Pages: 156-165

    • NAID

      10024967764

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of N-Methacryloyl-2-methylaziridine2009

    • Author(s)
      Takashi Ishizone, Junichi Kusakabe, Takashi Suzuki
    • Journal Title

      Macromolecular Symposia 279

      Pages: 21-28

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of well-defined random and block copolymers of 2-(1-adamantyl)-1, 3-butadiene with isoprene via anionic polymerization2009

    • Author(s)
      Shingo Kobayashi, Hiroshi Kataoka, Takashi Ishizone, Toshinori Kato, Tomohiro Ono, Syuji Kubotaka, Kikuo Arimoto, Hiroyuki Ogi
    • Journal Title

      Reactive and Functional Polymers 69

      Pages: 409-415

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of Styrenes Containing Adamantyl Skeletons2009

    • Author(s)
      Shingo Kobayashi, Hiroshi Kataoka, Takashi Ishizone
    • Journal Title

      Journal of Physics : Conference Series 184

      Pages: 12-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two dimentional nano-dot array engineering of block copolymer surface micelles on water surface2009

    • Author(s)
      Shusaku Nagao, Yu Matsushita, Satoshi Shinma, Takashi Ishizone, Takahiro Seki,
    • Journal Title

      Thin Solid Films 518

      Pages: 724-728

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Well-Defined Poly(ethylene-alt-1-vinyladamantane)via Living Anionic Polymerization of 2-(1-Adamantyl)-1,3-butadiene, Followed by Hydrogenation2009

    • Author(s)
      Shingo Kobayashi, Hiroshi Kataoka, Takashi Ishizone
    • Journal Title

      Macromolecules 42

      Pages: 5017-5026

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アダマンタン骨格を有する高分子の精密合成2009

    • Author(s)
      石曽根隆
    • Journal Title

      有機化学合成協会誌 67

      Pages: 156-165

    • NAID

      10024967764

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of New Thermoplastic Elastomers Containing Poly[4-(1-adamantyl)styrene] Hard Segments2008

    • Author(s)
      S.Kobayashi, H.Kataoka, T.Ishizone, T.Kato, T.Ono, S.Kobutaka, H.Ogi
    • Journal Title

      Macromolecules 41

      Pages: 5502-5508

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Hydrophobic Interaction of Polystyrene Surfaces by Spontaneous Segregation of Block Copolymers with Oligo(Ethylene Glycol) Methyl Ether Methacrylate Blocks : Force Measurements in Water Using Atomic Force Microscope with Hydrophobic Probes2008

    • Author(s)
      T.Ishizone, A.Seki, A.Oyane, H.Yokoyama
    • Journal Title

      Langmuir 24

      Pages: 5527-5533

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anionic Polymerizations of Oligo(ethylene glycol) Alkyl Ether Methacrylates : Effect of Side Chain Length and ω-Alkyl Group of Side Chain on Cloud Point in Water2008

    • Author(s)
      T.Ishizone, A.Seki, M.Hagiwara, S.Han, H.Yokoyama, A.Oyane, A.Deffieux, S.Carlotti
    • Journal Title

      Macromolecules 41

      Pages: 2963-2967

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living Anionic Polymerization of A-Methacryloyl-2-methylaziridine : Polymerizable N, N-Dialkylmethacrylamide2008

    • Author(s)
      T.Ishizone, T.Suzuki, J.Kusakabe
    • Journal Title

      Macromolecules 41

      Pages: 1929-1936

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization of Homopolymers Confined in Spherical or Cylindrical Nanodomains2008

    • Author(s)
      S.Nojima, Y.Ohguma, S.Namiki, T.Ishizone, K.Yamaguchi
    • Journal Title

      Macromolecules 41

      Pages: 1915-1918

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anionic Polymerizations of Oligo(ethylene glycol)Alkyl Ether Methacrylates : Effect of Side Chain Length and ω-Alkyl Group of Side Chain on Cloud Point in Water2008

    • Author(s)
      Takashi Ishizone, Akiko Seki, Mamoru Hagiwara, Seok Han, Hideaki Yokoyama, Ayako Oyane, Alain Deffieux, Stephane Carlotti
    • Journal Title

      Macromolecules 41

      Pages: 2963-2967

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization of Homopolymers Confined in Spherical or Cylindrical Nanodomains2008

    • Author(s)
      Shuichi Nojima, Yuya Ohguma, Shingo Namiki, Takashi Ishizone, Kazuo Yamaguchi
    • Journal Title

      Macromolecules 41

      Pages: 1915-1918

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of New Thermoplastic Elastomers Containing Poly[4-(l-adamantyl)styrene]Hard Segments2008

    • Author(s)
      Shingo Kobayashi, Hiroshi Kataoka, Takashi Ishizone, Toshinori Kato, Tomohiro, Ono, Syuji Kobutaka, Hiroyuki Ogi
    • Journal Title

      Macromolecules 41

      Pages: 5502-5508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Hydrophobic Interaction of Polystyrene Surfaces by Spontaneous Segregation of Block Copolymers with Oligo(ethylene glycol)Methyl Ether Methacrylate Blocks : Force Measurements in Water Using Atomic Force Microscope with Hydrophobic Probes2008

    • Author(s)
      Rui Zhang, Akiko Seki, Takashi Ishizone, Hideaki Yokoyama
    • Journal Title

      Langmuir 24

      Pages: 5527-5533

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synthesis of novel polymers containing adamantyl skeletons2010

    • Author(s)
      T.Ishizone
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      国際会議場ホノルル,米国ハワイ州
    • Year and Date
      2010-12-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis of novel polymers containing adamantyl skeletons2010

    • Author(s)
      Takashi Ishizone
    • Organizer
      PACIFICHEM2010
    • Place of Presentation
      米国ハワイ州ホノルル国際会議場
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of Polymers Containing Adamantyl Skeletons2010

    • Author(s)
      T.Ishizone
    • Organizer
      2010 International Symposium on Nano Structures
    • Place of Presentation
      POSCO International Center (Pohang, Korea).
    • Year and Date
      2010-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis of Polymers Containing Adamantyl Skeletons2010

    • Author(s)
      Takashi Ishizone
    • Organizer
      2010 International Symposium on Nano Structures
    • Place of Presentation
      POSCO International Center (Korea, Pohang)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Living Anionic Polymerization of Styrenes Containing Adamantyl Skeletons2010

    • Author(s)
      T.Ishizone
    • Organizer
      ISAOP-10
    • Place of Presentation
      東京工業大学蔵前ホール、東京
    • Year and Date
      2010-09-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Living Anionic Polymerization of Styrenes Containing Adamantyl Skeletons2010

    • Author(s)
      Takashi Ishizone
    • Organizer
      ISAOP-10
    • Place of Presentation
      東京工業大学蔵前ホール
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anionic Polymerizability of N-NDialkylmethacrylamides2010

    • Author(s)
      T.Ishizone
    • Organizer
      MACRO2010
    • Place of Presentation
      SECC, (Glasgow, UK)
    • Year and Date
      2010-07-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Anionic Polymerizability of N, N-Dialkylmethacrylamides2010

    • Author(s)
      Takashi Ishizone
    • Organizer
      MACR02010
    • Place of Presentation
      SECC, Glasgow, UK
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anionic polymerization of N,N-Dialkylmethacrylamides2010

    • Author(s)
      T.Ishizone
    • Organizer
      2010 JAPAN-TAIWAN BILATERAL POLYMER SYMPOSIUM
    • Place of Presentation
      北海道大学100周年記念館、札幌
    • Year and Date
      2010-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Anionic polymerization of N, N-Dialkylmethacrylamides2010

    • Author(s)
      Takashi Ishizone
    • Organizer
      2010 JAPAN-TAIWAN BILATERAL POLYMER SYMPOSIUM
    • Place of Presentation
      北海道大学100周年記念館
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Living anionic polymerization of oligo(ethylene glycol)methacrylates2009

    • Author(s)
      石曽根隆
    • Organizer
      2009 International symposium on Nano structures
    • Place of Presentation
      韓国光州科学技術院
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis of novel polymers containing adamantyl skeletons2009

    • Author(s)
      石曽根隆
    • Organizer
      2009 Japan-Taiwan Bilateral Polymer Symposium
    • Place of Presentation
      台湾大学Locke Hall
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anionic Polymerizability of N, N-Dialkylmethacrylamides2008

    • Author(s)
      石曽根隆
    • Organizer
      2nd Japan-Korea Joint Seminar 2008 and International Symposium
    • Place of Presentation
      東京工業大学(日本)
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Living Anionic Polymerizations of N, N-Dialkylmethacrylamides2008

    • Author(s)
      石曽根隆
    • Organizer
      42nd World Polymer Congress, MACRO2008
    • Place of Presentation
      台北国際会議場(台湾)
    • Year and Date
      2008-07-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthesis of Polymers Containing Adamantyl Skeletons2008

    • Author(s)
      石曽根隆
    • Organizer
      Prospects for the development of Chemistry and practical application of alicyclic compounds
    • Place of Presentation
      ボルゴグラード工科大学(ロシア)
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Book] Complex Macromolecular Architectures : Synthesis, Characterization, and Self-Assembly N.(Synthesis of Well-Defined Poly (meth)acrylamides with Varied Stereoregularity by Living Anionic Polymerization)(Hadjichristidis (Ed.))2011

    • Author(s)
      石曽根隆
    • Publisher
      Wiley, Asia
    • Related Report
      2010 Final Research Report
  • [Book] ベーシックマスター高分子化学(第10章アニオン重合)(西久保忠臣編)2011

    • Author(s)
      石曽根隆(分担)
    • Publisher
      オーム社
    • Related Report
      2010 Final Research Report
  • [Book] ベーシックマスター 高分子化学 西久保忠臣編2011

    • Author(s)
      石曽根隆(分担)
    • Total Pages
      394
    • Publisher
      オーム社
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 1-メチレンインダン重合体及びその製造方法、ブロック共重合体及びその製造方法、並びに、光学フィルム2010

    • Inventor(s)
      石曽根隆、高嶋務、椎橋彬
    • Industrial Property Rights Holder
      東京工業大学、新日本石油株式会社
    • Industrial Property Number
      2010-032777
    • Filing Date
      2010-02-17
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 1-メチレンテトラリン重合体及びその製造方法2010

    • Inventor(s)
      石曽根隆、高嶋務、椎橋彬
    • Industrial Property Rights Holder
      東京工業大学、新日本石油株式会社
    • Industrial Property Number
      2010-032781
    • Filing Date
      2010-02-17
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 抗血栓性高分子組成物2010

    • Inventor(s)
      横山英明、大矢根綾子、石曽根隆、酒井克子
    • Industrial Property Rights Holder
      産業技術総合研究所
    • Acquisition Date
      2010-10-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] N-メタクリロイルアジリジン系重合体ならびにその重合体の製造方法2010

    • Inventor(s)
      石曽根隆、小林真盛
    • Industrial Property Rights Holder
      東京工業大学、リンテソク株式会社
    • Acquisition Date
      2010-09-17
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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