| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Glycosaminoglycans are sulfated polysaccharides having important biological activities, which regulate cellular differentiation and development. In the present study, precision synthesis of heparan sulfate and sulfated-Lewis X oligomers were challenged, which have quite complex structures and are difficult to be prepared chemically. The fluoride monomer for heparan sulfate synthesis was successfully prepared, and sulfated Lewis X-related oligosaccharides were obtained successfully. Further, potent inhibitors for heparanase were also synthesized successfully.
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