Development of chaperone-peptide beads for control of toxic nano-particle
Project/Area Number |
20550111
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Polymer chemistry
|
Research Institution | Kyoto Institute of Technology |
Principal Investigator |
TANAKA Naoki Kyoto Institute of Technology, 工芸科学研究科, 准教授 (60243127)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 環境分析 / 自己組織化 / 生体材料 / 脳・神経 / ナノ毒性 |
Research Abstract |
To develop chaperone-bead for detecting toxic nano-particle, the property of the chaperone peptide derived from the substrate binding site of the molecular chaperone αA-crystallin was studied. Chaperone peptide which corresponds to the residues 71-75 of αA-crystallin self-assemble into nano-scale fibril to efficiently reduce the aggregation of the substrate model protein. The substrate recognition mechanism of a the chaperon-peptide was studied.
|
Report
(4 results)
Research Products
(11 results)