| Project/Area Number |
20550153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHMAE Eiji (2010) Hiroshima University, 大学院・理学研究科, 助教 (30284152)
月向 邦彦 (2008-2009) Hiroshima University, 大学院・理学研究科, 特任教授 (10023467)
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| Co-Investigator(Kenkyū-buntansha) |
大前 英司 広島大学, 大学院・理学研究科, 助教 (30284152)
|
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| Research Collaborator |
MATSUO Koichi 広島大学, 放射光科学研究センター, 特任助教 (40403620)
WOODY Robert W. 米国コロラド州立大学, 教授
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射光 / 真空紫外円二色性 / タンパク質 / 二次構造解析 / ニューラルネットワーク法 / 糖類 |
|---|
| Research Abstract |
Synchrotron-radiation vacuum-ultraviolet circular dichroism (VUVCD) spectroscopy was applied for the detailed structural analysis of biomolecules which was difficult by a conventional CD spectroscopy as follows : (1) prediction of amino acid sequence of protein secondary structures ; comprehensive secondary-structure analysis of disulfide variants of lysozyme ; (3) experimental and theoretical analyses of VUVCD spectra of mono- and polysaccharides ; (4) secondary structure analysis of acid-glycoprotein ; and (5) structural analysis of amyloid fibrils.
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