| Project/Area Number |
20550157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | The Noguchi Institute |
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Principal Investigator |
YAMANOI Takashi The Noguchi Institute, 研究部, 主任研究員 (20182595)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Masaya 公益財団法人野口研究所, 研究部, 研究員 (20321672)
ODA Yoshiki 公益財団法人野口研究所, 研究部, 研究員 (00442567)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 抗ピロリ / ピロリ菌 / αGlcNAc / ステロイド / N-アセチル-グルコサミン / グリコシド / クラスター / 医薬品 / シクロデキストリン / 抗菌剤 |
|---|
| Research Abstract |
Aiming to develop the antimicrobial agent for H. pylori, a novel α-stereoselective glycosidation method of GlcNAc derivatives for producing the αGlcNAc glycosides has been successfully developed. This method was applicable to the productions of several kinds of αGlcNAc glycosides having a steroid structure, which led to the partial library construction of the αGlcNAc derivatives. In addition, the αGlcNAc assembly, which was expected to have a highly efficient antimicrobial activity toward H. pylori based on the sugar-cluster effect, was synthesized using cyclodextrin as a scaffolding molecule.
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