| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
Artificial metalloenzymes containing unnatural multinuclear core were constructed in this project. Dioxygen-binding diiron protein, DcrH-Hr, was studied to elucidate the characteristics and the approaches using a mutation of amino acid residues around the active site led to conversion of the oxygen-binding function. Successful incorporation of a diiron hexacarbonyl core into the protein matrix of cytochrome c provided us artificial hydrogenase capable of photocatalytic hydrogen evolution in an aqueous solution.
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