| Project/Area Number |
20560070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
|
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| Research Institution | Kanazawa University |
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Principal Investigator |
TANAKA Shigeo Kanazawa University, 環日本海域環境研究センター, 准教授 (20262602)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAKOSHI Kenichi 金沢大学, 自然科学研究科, 教授 (40014310)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨形成 / 力学刺激 / 骨芽細胞 / 再生骨 / 再生医療 / ティッシュエンジニアリング / ティッシュ・エンジニアリング |
|---|
| Research Abstract |
It is believed that strain-induced fluid flow (SIFF) stimulates osteogenic response of bone cells, resulting in adaptive bone formation. However, the mechanism of the osteogenic ability of SIFF is not fully understood. In this research, the ability of SIFF was investigated using regenerative bones made of osteoblasts and porous scaffolds. The results showed that SIFF promotes the ostegenesis of regenerated bones. This ability of SIFF was influenced by the porosity and material of scaffold, and the frequency of mechanical stimulation. These findings contribute to further understanding of the bone mechano-biology and the progress of bone tissue engineering.
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