Evaluation of time response of skin cells under artificial ischemia condition and a delay of pressure ulcer through an adjustment of physical environment
| Project/Area Number |
20560078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
YAMADA Hiroshi Kyushu Institute of Technology, 大学院・生命体工学研究科, 教授 (00220400)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYATA Shogo 慶應義塾大学, 理工学部, 講師 (70376515)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生体力学 / 褥瘡 / 微小血管 / 有限要素解析 / 体積変化 / 粘弾性 / 空気圧 / 周期的負荷 / 線維芽細胞 / 低酸素 / 接着 / 温度 / 二価陽イオン / エネルギ代謝 |
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| Research Abstract |
Single-layered rabbit fibroblast-like cells in culture are insensitive to a reduction of oxygen and sensitive to the temperature due to the fact that a rate of detachment from the substrate decreases significantly for the cells in divalent cation free medium at 25 degrees centigrade compared to those at 37 degrees centigrade. Results from the finite element analysis for the soft tissues with microvessels near a bone prominence which is compressed onto a mattress show that the microvessels deform largely if the soft tissue is compressive over a long time scale and that an air support is valuable. To delay an occurrence of pressure ulcer, a prototype was created to support the soft tissues near a bone prominence by supplying the air with about 10 kPa to a polyethylene tube.
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Report
(4 results)
Research Products
(11 results)
