Focused Ultrasound Controlled Cavitation Bubble Collapse and Promotion of Sonoporation Effect

• Project/Area Number: 20560144
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Hokkaido University of Education
• Principal Investigator: TOMITA Yukio Hokkaido University of Education, 教育学部, 教授 (00006199)
• Co-Investigator(Renkei-kenkyūsha): KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: キャビテーション / 超音波 / ソノポレーション / マイクロジェット / 衝撃波 / 気泡 / マイクロバブル / 分子導入

Research Abstract

The relation between Sonazoid destruction and the resultant cavitation phenomena has been investigated by employing ultrasound waves with the frequency of 1 MHz which were irradiated from two types of US probes with a flat boundary as well as a curved boundary. It was found that Sonazoid microbubbles were rapidly destroyed and the survival number was reduced to half the original number within 100 ms after ultrasound irradiation. The debris of microbubbles played a role of cavitation nuclei from which a large number of cavitation bubbles grew. A liquid micro-jet and a shock wave occurred during the short period of the bubble collapse. An impact pressure resulting from one of these short term phenomena seems to be an important cause of sonoporation which could make a fine hole in the cell membrane transiently.

Research Products

• [Journal Article] 超音波によるキャピラリ波と噴霧の形成 (2011)
  • Author(s): 冨田幸雄
  • Journal Title: 日本産業技術教育学会北海道支部会研究論文集 Volume: 24 Pages: 15-18
• [Journal Article] 集束超音波によるキャビテーションの生成と噴霧形成、キャビテーションに関するシンポジウム(第15回)講演論文集 (2010)
  • Author(s): 冨田幸雄、小玉哲也、他
  • Journal Title: 電子媒体(DVD)
  • Peer Reviewed
• [Journal Article] 超音波の作用によるマイクロバブルの破壊とキャビテーション気泡の生成 (2010)
  • Author(s): 冨田幸雄、小玉哲也、他
  • Journal Title: 混相流 24巻 Pages: 162-168
  • NAID: 10026407639
  • Peer Reviewed
• [Journal Article] 超音波の作用によるマイクロバブルの破壊とキャビテーション気泡の生成 (2010)
  • Author(s): 冨田幸雄
  • Journal Title: 混相流 Volume: 24 Pages: 162-168
  • NAID: 10026407639
  • Peer Reviewed
• [Journal Article] 集束超音波によるキャビテーションの生成と噴霧形成 (2010)
  • Author(s): 冨田幸雄
  • Journal Title: キャビテーションに関するシンポジウム(第15回)講演論文集 Volume: 電子媒体(DVD)
  • Peer Reviewed
• [Journal Article] 電気分解によるマイクロバフルの発生と超音波との相互作用 (2010)
  • Author(s): 冨田幸雄
  • Journal Title: 日本産業技術教育学会北海道支部会研究論文集 第23号 Pages: 26-29
• [Journal Article] ブラインシュリンプの破壊に及ぼす超音波キャビテーションの影響 (2010)
  • Author(s): 冨田幸雄
  • Journal Title: 日本産業技術教育学会北海道支部会研究論文集 第23号 Pages: 30-33
• [Journal Article] Microbubble disruption by ultrasound and induced cavitation phenomena、 Proceedings of the 7^<th> International Symposium on Cavitation Ann Arbor、 U.S.A. August (2009)
  • Author(s): 冨田幸雄, 小玉哲也, 他
  • Journal Title: 電子媒体(DVD) Paper No.109 Pages: 16-20
  • Peer Reviewed
• [Journal Article] Cavitation bubbles mediated molecular delivery during sonoporation (2009)
  • Author(s): 小玉哲也, 冨田幸雄, 他
  • Journal Title: Journal of Biomechanical Science and Engineering JSME Vol.4、No.1 Pages: 124-140
  • NAID: 130000107450
  • Peer Reviewed
• [Journal Article] Microbubble disruption by ultrasound and induced cavitation phenomena (2009)
  • Author(s): 冨田幸雄
  • Journal Title: Proceedings of the 7^<th> International Symposium on Cavitation, CAV2009 電子媒体(DVD)
  • Peer Reviewed
• [Journal Article] Cavitation bubbles mediated molecular delivery during sonoporation (2009)
  • Author(s): T. Kodama
  • Journal Title: Journal of Biomechanical Science and Engineering, JSME Vol.4, No.1 Pages: 124-140
  • NAID: 130000107450
  • Peer Reviewed
• [Journal Article] 超音波キャビテーションの発生とマイクロバブルの破壊に関する実験的研究 (2009)
  • Author(s): 冨田幸雄
  • Journal Title: キャビテーションに関するシンポジウム(第14回)講演論文集 電子媒体(DVD)
  • Peer Reviewed
• [Journal Article] 超音波キャビテーションの初生に及ぼす定在波生成条件の影響 (2009)
  • Author(s): 冨田幸雄
  • Journal Title: 日本産業技術教育学会北海道支部会研究論文集 第22号 Pages: 1-4
• [Journal Article] Peeling off effect and damage pit formation by ultrasonic cavitation (2008)
  • Author(s): 冨田幸雄, 小玉哲也,他
  • Journal Title: Scientific Bulletin of the Politechnica University of Timisoara、 Romania、 Transactions on Mechanics (Tom)(ISSN1224-6077) 53(67)、Special Issue Pages: 19-24
  • Peer Reviewed
• [Journal Article] Peeling off effect and damage pit formation by ultrasonic cavitation (2008)
  • Author(s): Y. Tomita
  • Journal Title: Scientific Bulletin of the "Politechnica University of Timisoara, Romania, Transactions on Mechanics Special Issue, Tom 53(67) Pages: 19-24
  • Peer Reviewed
• [Presentation] Sonazoid destruction and cavitation phenomena induced by focused ultrasound waves (2010)
  • Author(s): 冨田幸雄
  • Organizer: Presented at the meeting as a part of Joint Research Project under the Japan-Korea Basic Scientific Cooperation Program for FY 2009
  • Place of Presentation: Jeju National University、 Republic of Korea
  • Year and Date: 2010-11-29
• [Presentation] Sonazoid destruction and cavitation phenomena induced by focused ultrasound waves (2010)
  • Author(s): Y.Tomita
  • Organizer: Presented at the meeting as a part of Joint Research Project under the Japan-Korea Basic Scientific Cooperation Program for FY 2009
  • Place of Presentation: Jeju National University, Republic of Korea
  • Year and Date: 2010-11-29
• [Presentation] 集束超音波によるキャビテーションの生成と噴霧形成 (2010)
  • Author(s): 冨田幸雄
  • Organizer: キャビデーションに関するシンポジウム(第15回)
  • Place of Presentation: 大阪府立大学(大阪)
  • Year and Date: 2010-11-22
• [Presentation] 集束超音波によるキャピラリ波と噴霧の形成 (2010)
  • Author(s): 端場大竜
  • Organizer: 日本産業技術教育学会北海道支部会第24回大会
  • Place of Presentation: 北海道教育大学釧路校(釧路)
  • Year and Date: 2010-10-30
• [Presentation] 集束超音波によるソナゾイドの破壊実験 (2010)
  • Author(s): 冨田幸雄
  • Organizer: 日本機械学会2010年度年次大会
  • Place of Presentation: 名古屋工業大学(名古屋)
  • Year and Date: 2010-09-06
• [Presentation] 集束超音波で生成するキャビテーションと液体ジェットの衝突による破壊作用 (2010)
  • Author(s): 冨田幸雄
  • Organizer: 日本混相流学会年会講演会2010
  • Place of Presentation: 静岡大学(浜松)
  • Year and Date: 2010-07-19
• [Presentation] 超電気分解によるマイクロバフルの発生と超音波との相互作用 (2009)
  • Author(s): 皆川隆一郎
  • Organizer: 日本産業技術教育学会北海道支部会第23回大会
  • Place of Presentation: 北海道教育大学札幌校(札幌)
  • Year and Date: 2009-10-31
• [Presentation] ブラインシュリンプの破壊に及ぼす超音波キャビテーションの影響 (2009)
  • Author(s): 下村文吾
  • Organizer: 日本産業技術教育学会北海道支部会第23回大会
  • Place of Presentation: 北海道教育大学札幌校(札幌)
  • Year and Date: 2009-10-31
• [Presentation] Microbubble disruption by ultrasound and induced cavitation phenomena (2009)
  • Author(s): 冨田幸雄
  • Organizer: the 7th International Symposium on Cavitation、 CAV2009
  • Place of Presentation: Ann Arbor、 U.S.A
  • Year and Date: 2009-08-20
• [Presentation] Microbubble disruption by ultrasound and induced cavitation phenomena (2009)
  • Author(s): 冨田幸雄
  • Organizer: Presented at the 7^<th> International Conference on Cavitation, CAV2009
  • Place of Presentation: Ann Albor, U.S.A.
  • Year and Date: 2009-08-20
• [Presentation] 超音波の作用によるマイクロバブルの破壊とキャビテーション気泡の挙動 (2009)
  • Author(s): 冨田幸雄
  • Organizer: 日本混相流学会年会講演会2009
  • Place of Presentation: 熊本大学(熊本)
  • Year and Date: 2009-08-09
• [Presentation] 超音波キャビテーションの発生とマイクロバブルの破壊に関する実験的研究 (2009)
  • Author(s): 冨田幸雄
  • Organizer: 日本学術会議機械工学委員会主催「キャビテーションに関するシンポジウム(第14回)」
  • Place of Presentation: 東北大学「片平さくらホール」(仙台)
  • Year and Date: 2009-03-20
• [Presentation] 超音波キャビテーションの初生に及ぼす定在波生成条件の影響 (2008)
  • Author(s): 打越亮介
  • Organizer: 日本産業技術教育学会北海道支部会第22回大会
  • Place of Presentation: 北海道教育大学札幌校(札幌)
  • Year and Date: 2008-10-25
• [Presentation] Peeling off effect and damage pit formation by ultrasonic cavitation (2008)
  • Author(s): 冨田幸雄
  • Organizer: the International Conference on Hydraulic and Machinery and Equipments
  • Place of Presentation: Politechnic University of Timisoara、 Timisoara、 Romania(Invited Lecture)
  • Year and Date: 2008-10-16
• [Presentation] Peeling off effect and damage pit formation by ultrasonic cavitation (2008)
  • Author(s): Y. Tomita
  • Organizer: Presented as an Invited Lecture at the International Conference on Hydraulic Machinery and Equipments
  • Place of Presentation: Politechnic University of Timisoara, Timisoara, Romania
  • Year and Date: 2008-10-16
• [Presentation] Physical effect of bubbles in cavitation and underwater acoustics (2008)
  • Author(s): 冨田幸雄
  • Organizer: Presented at Open Seminar of Environmental Studies
  • Place of Presentation: Saint Mary's University、 Halifax、 Canada
  • Year and Date: 2008-10-03
• [Presentation] Physical effect of bubbles in cavitation and underwater acoustics (2008)
  • Author(s): Y. Tomita
  • Organizer: Open Seminar of Environmental Studies
  • Place of Presentation: Saint Mary's University, Halifax, Canada
  • Year and Date: 2008-10-03