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Development of the next-generation simulation system for cardiovascular circulatory function

Research Project

Project/Area Number 20560253
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionOsaka University

Principal Investigator

AKAGAWA Eiki  Osaka University, 知的資産部, 室長 (40416219)

Co-Investigator(Kenkyū-buntansha) LEE Hwangsung  国立循環器病センター, 人工臓器部, 特任研究員 (10463275)
Co-Investigator(Renkei-kenkyūsha) HOMMA Akihiko  東京電機大学, 理工学部, 准教授 (20287428)
OHNUMA Kentarou  独立行政法人国立循環器病研究センター, 人工臓器部, 流動研究員 (50527992)
SUMIKURA Hirohito  独立行政法人国立循環器病研究センター, 人工臓器部, 流動研究員 (20433998)
FUJII Yutaka  独立行政法人国立循環器病研究センター, 心臓機能生理部, 流動研究員 (20589303)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsシミュレータ / 流体工学 / 循環器 / シミュレーション工学 / 流本工学 / 循環器・高血圧 / 医療・福祉
Research Abstract

In this study, the newly circulation simulator which reproduce blood flow and blood pressure wave forms was developed. This circulation simulator was composed of the pulsatile pump using closed chamber which mimics the left ventricle, the closed chamber which mimics compliance of aorta, the control valve which mimics resistance of peripheral, and the pipeline connected by fitting ferrule reservoir which mimics left atrium. It was suggested that a wide range of circulatory states such as failure and healthy heart may be reproduced under conditions of children and adults, because blood flow wave form can be obtained by using this simulator.

Report

(3 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010 2009 2008 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Effects of the leaflets' geometry on the flow field in three bileaflet valves : using a pneumatic ventricular assist device2009

    • Author(s)
      H.Lee, et al.
    • Journal Title

      Journal of Artificial Organs 12

      Pages: 98-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 補助循環装置用耐久試験装置の開発と特性評価2011

    • Author(s)
      大沼健太郎, 住倉博仁, 本間章彦, 妙中義之, 向林宏, 片野一夫, 巽英介.
    • Organizer
      第39回人工心臓と補助循環懇話会
    • Place of Presentation
      米子
    • Related Report
      2010 Final Research Report
  • [Presentation] Heart rate variability in ventricular assist device animals in view of the mathematical models2010

    • Author(s)
      E.Akagawa, Y.Takewa, H.Sumikura, K.Ohnuma, Y.Kakuta, A.Homma, S.Hanada, Y.Zhou, T.Mizuno, T.Tsukiya, E.Tatsumi.
    • Organizer
      56^<th> Annual Conference American Society for Artificial Internal Organs
    • Place of Presentation
      Baltimore
    • Related Report
      2010 Final Research Report
  • [Presentation] 数理工学的解析による補助人工心臓装着下での心拍変動2009

    • Author(s)
      赤川英毅, 武輪能明, 住倉博仁, 角田幸秀, 本間章彦, 大沼健太郎, 花田繁, 周粤閲, 水野敏秀, 巽英介
    • Organizer
      第47回日本人工臓器学会大会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 数理的に解析した補助人工心臓装着患者の心拍変動2009

    • Author(s)
      赤川英毅, 市川肇, 大沼健太郎, 松宮護郎, 本間章彦, 巽英介, 妙中義之, 澤芳樹.
    • Organizer
      第48回日本生体医工学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 数理的手法を用いた補助人工心臓装着患者の心拍変動解析2009

    • Author(s)
      赤川英毅, 市川肇, 大沼健太郎, 松宮護郎, 本間章彦, 巽英介, 妙中義之, 澤芳樹.
    • Organizer
      第37回人工心臓と補助循環懇話会
    • Place of Presentation
      越後湯沢
    • Related Report
      2010 Final Research Report
  • [Presentation] 数理的解析からみた補助人工心臓装着患者の心拍変動2008

    • Author(s)
      赤川英毅, 市川肇, 大沼健太郎, 松宮護郎, 本間章彦, 巽英介, 妙中義之, 澤芳樹.
    • Organizer
      第46回日本人工臓器学会大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Remarks] 現在,特許申請の準備中であるため,シミュレータ構造等が明らかになるような研究発表は実施していない.

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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