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Development of multi-layered and structured skin model and search of blood vessel structure in a three-dimensional manner

Research Project

Project/Area Number 20560391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionMuroran Institute of Technology

Principal Investigator

AIZU Yoshihisa  室蘭工業大学, 大学院・工学研究科, 教授 (20212350)

Co-Investigator(Renkei-kenkyūsha) NISHIDATE Izumi  東京農工大学, 大学院・共生科学技術研究院, 准教授 (70375319)
YUASA Tomonori  室蘭工業大学, 大学院・工学研究科, 准教授 (60241410)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords計測システム / 可視化 / 生体計測 / 分光計測 / 皮膚計測 / 計測工学 / 皮膚科学
Research Abstract

We studied to develop a novel technique of searching a position of a blood vessel in skin tissue in a three dimensional manner for measurements of a glucose level, which is used for diabetic patients. We designed and developed a new skin model having nine layers and a method for multi-layered Monte Carlo simulation of spectral reflectance. We also developed a novel technique for fabricating an artificial thin layer of skin with 0.1-mm thickness and realized multi-layered human skin phantom. Using these model and methods, we studied a method and an optical system for measuring depth and diameter of veins in skin tissue using spectroscopic imaging. We finally confirmed the usefulness of this method in experiments on human arms.

Report

(4 results)
  • 2011 Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008

All Journal Article (15 results) (of which Peer Reviewed: 10 results) Presentation (12 results)

  • [Journal Article] 皮膚組織多層構造モデリングと光伝搬シミュレーション2011

    • Author(s)
      相津佳永
    • Journal Title

      日本機械学会誌

      Volume: Vol.114, No.1112 Pages: 541-541

    • Related Report
      2011 Final Research Report
  • [Journal Article] Monte Carlo simulation of spectral reflectance using a multilayered skin tissue model2010

    • Author(s)
      Takaaki MAEDA, Naomi ARAKAWA, Motoji TAKAHASHI and Yoshihisa AIZU
    • Journal Title

      Optical Review

      Volume: vol.17, No.3 Pages: 223-229

    • NAID

      10026357879

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 真皮の病変2010

    • Author(s)
      宇谷厚志, 相津佳永
    • Journal Title

      Visual Dermatology

      Volume: Vol.9, No.4 Pages: 388-394

    • Related Report
      2011 Final Research Report
  • [Journal Article] 真皮の病変2010

    • Author(s)
      宇谷厚志
    • Journal Title

      Visual Dermatology

      Volume: 9 Pages: 388-394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monte Carlo simulation of spectral reflectance using a multilayered skin tissue model2010

    • Author(s)
      Takaaki MAEDA
    • Journal Title

      Optical Review

      Volume: 17 Pages: 223-229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of Estimation Parameters in Bio-speckle Blood Flow Imaging2010

    • Author(s)
      Naomichi Yokoi
    • Journal Title

      Optical Review

      Volume: 17 Pages: 230-238

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive exponential approximation of optical density ratio using third-order regression equations for depth profiling of a blood inclusion in a skin tissue model2009

    • Author(s)
      Takaaki MAEDA, Izumi NISHIDATE, and Yoshihisa AIZU
    • Journal Title

      Optics & Laser Technology

      Volume: 41, No.6 Pages: 755-763

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多層構造皮膚モデルに基づく分光反射率のシミュレーション2009

    • Author(s)
      相津佳永
    • Journal Title

      光技術コンタクト

      Volume: Vol.47, No.1 Pages: 5-13

    • Related Report
      2011 Final Research Report
  • [Journal Article] Adaptive exponential approximation of optical density ratio using third-order regression equations for depth profiling of a blood inclusion in a skin tissue model2009

    • Author(s)
      Takaaki MAEDA
    • Journal Title

      Optics & Laser Technology Vol.41

      Pages: 755-763

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of arterial inflow and venous capacitance in human skin by use of RGB images2009

    • Author(s)
      Izumi Nishidate
    • Journal Title

      Proceedings of SPIE-OSA Biomedical Optics vol.7368

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous imaging of blood flow and hemoglobin concentration change in skin tissue using NIR speckle patterns2009

    • Author(s)
      Yoshihisa Aizu
    • Journal Title

      Proceedings of SPIE-OSA Biomedical Optics vol.7371

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多層構造皮膚モデルに基づく分光反射率のシミュレーション2009

    • Author(s)
      相津佳永
    • Journal Title

      光技術コンタクト Vol.47

      Pages: 5-13

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Visualizing of skin chromophore concentrations by use of RGB images2008

    • Author(s)
      Izumi Nishidate, Kiyohiro Sasaoka, Testuya Yuasa, Kyuichi Niizeki, Takaaki Maeda, and Yoshihisa Aizu
    • Journal Title

      Optics Letters

      Volume: 33, No.19 Pages: 2263-2265

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing of skin chromophore concentrations by use of RGB images2008

    • Author(s)
      Izumi Nishidate
    • Journal Title

      Optics Letters Vol.33

      Pages: 2263-2265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 散乱と吸収を利用するバイオスペックルイメージング2008

    • Author(s)
      相津佳永
    • Journal Title

      光技術コンタクト Vol.46

      Pages: 16-22

    • Related Report
      2008 Annual Research Report
  • [Presentation] 皮下局所血液領域の深さ・厚み計測のための使用波長の検討2011

    • Author(s)
      長沼大史,田中規之,西舘泉,前田貴章,新関久一,相津佳永
    • Organizer
      Optics & Photonics Japan 2011
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Noninvasive and noncontact imaging of skin hemodynamics using a digital RGB camera2011

    • Author(s)
      Izumi Nishidate, Tatsuya Kawase, Noriyuki Tanaka, Kyuichi Niizeki, Yoshihisa Aizu
    • Organizer
      Optics & Photonics Japan 2011,日韓生体医用光学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Monte Carlo simulation of light penetration into skin tissue using a nine-layered skin model2011

    • Author(s)
      N. Akiyoshi, T. Maeda, I. Nishidate, H. Funamizu, and Y. Aizu
    • Organizer
      9th Japan-Finland Joint Symposium on Optics in Engineering, OIE'11,Turku
    • Place of Presentation
      トゥルク・フィンランド
    • Year and Date
      2011-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 多層構造皮膚モデルを用いた光侵達のモンテカルロ解析2011

    • Author(s)
      秋吉騎慎,前田貴章,西舘泉,船水英希,相津佳永
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形
    • Year and Date
      2011-09-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 多層構造モデルに基づく皮膚組織内光浸達のモンテカルロシミュレーション2011

    • Author(s)
      秋吉騎慎,前田貴章,西舘泉,船水英希,相津佳永
    • Organizer
      応用物理学会第48回光波センシング技術研究会講演会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 等吸収点反射率画像による皮下静脈血管径変化の計測2010

    • Author(s)
      長沼大史,田中規之,西舘泉,前田貴章,新関久一,相津佳永
    • Organizer
      Optics & Photonics Japan 2010
    • Place of Presentation
      東京
    • Year and Date
      2010-11-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 真皮内病変に由来する皮膚色のモンテカルロシミュレーション2010

    • Author(s)
      鎌田沙由里
    • Organizer
      Optics & Photonics Japan 2010
    • Place of Presentation
      p.646-647
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Skin image reconstruction using Monte Carlo based color generation2010

    • Author(s)
      Yoshihisa Aizu, Takaaki Maeda, Tomohiro Kuwahara, and Tetsuji Hirao
    • Organizer
      Information Optics and Optical Data Storage, SPIE Photonics Asia 2010 symposium in Beijing
    • Place of Presentation
      北京・中国
    • Year and Date
      2010-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 光波センシングを切り拓くイメージング技術の進展【招待講演】2010

    • Author(s)
      相津佳永
    • Organizer
      第57回応用物理学関係連合講演会
    • Place of Presentation
      東海大学湘南キャンパス(神奈川県)
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多層構造型モンテカルロモデルに基づく皮膚の分光反射率特性2009

    • Author(s)
      前田貴章,鎌田沙由里,吉村淳,桑原智裕,平尾哲二,高橋元次,相津佳永
    • Organizer
      応用物理学会第44回光波センシング技術研究会講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 皮下血液層モデルの深さ・厚み計測における照明・撮影角度の光学特性2009

    • Author(s)
      佐藤啓介,前田貴章,西舘泉,相津佳永
    • Organizer
      日本機械学会第21回バイオエンジニアリング講演会
    • Place of Presentation
      札幌
    • Year and Date
      2009-01-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 医用生体情報光センシングのこれから【招待講演】2008

    • Author(s)
      相津佳永
    • Organizer
      応用物理学会第42回光波センシング技術研究会講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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