Development of measurement system for brain function dynamics by using magneto-encephalography and transcranial magnetic stimulation

• Project/Area Number: 20560400
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Hiroshima City University
• Principal Investigator: HIWAKI Osamu Hiroshima City University, 情報科学研究科, 教授 (30264948)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 経頭蓋磁気刺激 / 脳磁界 / 脳機能ダイナミクス / 随意運動 / 第一次運動野 / 電流源推定

Research Abstract

In this study, we developed a system for investigation of the relationship between the afferent signals elicited by an electrical stimulus of a peripheral nerve and the efferent signals produced by a transcranial magnetic stimulation (TMS) of the motor cortex by using magneto-encephalography (MEG). The dynamic relation between the afferent and efferent signals was investigated by using the system we developed. The results suggested that the activation and direction of the current dipole in the primary somatosensory cortex was related to the effect of the afferent signals on the motor function.

Research Products

• [Journal Article] 手指の到達運動における外部力場の安定性の差異に対する運動適応 (2011)
  • Author(s): 福田浩士、小田垣雅人、樋脇治
  • Journal Title: 生体医工学 49(1) Pages: 100-107
  • NAID: 130004947410
  • Peer Reviewed
• [Journal Article] Disturbance on Inhibitory Control of Reaching Finger Movement Caused by Transcranial Magnetic Stimulation (2011)
  • Author(s): Osamu Hiwaki, Naoyuki Ishimaru, Hiroshi Fukuda
  • Journal Title: Proc.of IEEE Neural Engineering 5th Conference Pages: 638-641
  • Peer Reviewed
• [Journal Article] Identification of Stimulated Sites Using Artificial Neural Networks Based on Transcranial Magnetic Stimulation-Elicited Motor Evoked Ptentials and Finger Forces (2010)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Journal Title: 130(12) Pages: 2204-2209
  • Peer Reviewed
• [Journal Article] Identification of stimulated sites using artificial neural networks based on transcranial magnetic stimulation-elicited motor evoked potentials and finger forces (2010)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Journal Title: IEEJ Transactions on Electronics, Information and Systems 130(12) Pages: 2204-2209
  • NAID: 10027458347
  • Peer Reviewed
• [Journal Article] Identification of Stimulated Sites Using Artificial Neural Networks Based on Transcranial Magnetic Stimulation-Elicited Motor Evoked Ptentials and Finger Forces (2010)
  • Author(s): Hiroshi Fukuda, Masato Odagaki, Osamu Hiwaki
  • Journal Title: IEEJ Transaction on Electronics, Information and Systems Volume: 130(12) Pages: 2204-2209
  • Peer Reviewed
• [Journal Article] 手指の到達運動における外部力場の安定性の差異に対する運動適応 (2010)
  • Author(s): 福田浩士、小田垣雅人、樋脇治
  • Journal Title: 生体医工学 Volume: 49(1) Pages: 100-107
  • NAID: 130004947410
  • Peer Reviewed
• [Journal Article] A Method for Estimation of Stimulated Brain Sites Based on Columnar Structure of Cerebral Cortex in Transcranial Magnetic Stimulation (2009)
  • Author(s): Osamu Hiwaki, Tomonori Inoue
  • Journal Title: Journal of Applied Physics 105(7)
  • Peer Reviewed
• [Journal Article] Brain Activity during Bilateral Rapid Alternate Finger Tapping Measured with Magnetoencephalography (2009)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Journal Title: Journal of Applied Physics 105(7)
  • Peer Reviewed
• [Journal Article] Effect of Transcranial Magnetic Stimulation on Force of Finger Pinch (2009)
  • Author(s): 小田垣雅人, 福田浩士, 樋脇治
  • Journal Title: Journal of Applied Physics 105(7)
  • Peer Reviewed
• [Journal Article] Influence of Transcranial Magnetic Stimulation on Muscle Activity during Finger Movement (2009)
  • Author(s): Masato Odagaki, Sanae Ohishi, Hiroshi Fukuda, Osamu Hiwaki
  • Journal Title: IEEJ Transactions on Electrical and Electronic Engineering 4(1) Pages: 121-124
  • NAID: 10025773951
  • Peer Reviewed
• [Journal Article] Precise Coil Positioning System Using Multi-articular Arm for Location of Stimulated Brain Area in Transcranial Magnetic Stimulation (2009)
  • Author(s): Masato Odagaki, Tomonori Inoue, Taro Ikeda, Hiroshi Fukuda, Osamu Hiwaki
  • Journal Title: Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering Pages: 42-45
  • Peer Reviewed
• [Journal Article] A neural network for estimation of coil position in transcranial magnetic stimulation (2009)
  • Author(s): Hiroshi Fukuda, Masato Odagaki, Osamu Hiwaki
  • Journal Title: Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering Pages: 183-186
  • Peer Reviewed
• [Journal Article] Effects of Transcranial Magnetic Stimulation on Voluntary Thumb Movement (2009)
  • Author(s): Osamu Hiwaki, Masato Odagaki, Hiroshi Fukuda
  • Journal Title: Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering Pages: 195-198
  • Peer Reviewed
• [Journal Article] A Method for Estimation of Stimulated Brain Sites Based on Columnar Structure of Cerebral Cortex in Transcranial Magnetic Stimulation (2009)
  • Author(s): Osamu Hiwaki, Tomonori Inoue
  • Journal Title: Journal of Applied Physics VOL. 105, No. 7
  • Peer Reviewed
• [Journal Article] Brain Activity during Bilateral Rapid Alternate Finger Tapping Measured with Magnetoencephalography (2009)
  • Author(s): Hiroshi Fukuda, Masato Odagaki, Osamu Hiwaki
  • Journal Title: Journal of Applied Physics VOL. 105, No. 7
  • Peer Reviewed
• [Journal Article] Effect of Transcranial Magnetic stimulation on Force of Finger Pinch (2009)
  • Author(s): Masato Odagaki, Hiroshi Fukuda, Osamu Hiwaki
  • Journal Title: Journal of Applied Physics VOL. 105, No. 7
  • Peer Reviewed
• [Journal Article] Influence of Transcranial Magnetic stimulation on Muscle Activity during Finger Movement (2009)
  • Author(s): Masato Odagaki, Sanae Ohishi, Hiroshi Fukuda, Osamu Hiwaki
  • Journal Title: IEEJ Transactions on Electrical and Electronic Engineering VOL. 4, NO. 1 Pages: 121-124
  • NAID: 10025773951
  • Peer Reviewed
• [Journal Article] 両手指の連打タッピング運動における高密度脳電位計測 (2008)
  • Author(s): 福田浩士、小田垣雅人、樋脇治
  • Journal Title: 生体医工学 46(6) Pages: 684-689
  • NAID: 110007098777
  • Peer Reviewed
• [Journal Article] Suppression of Electromyogram of Hand Muscle Elicited by Transcranial Magnetic Stimulation Over the Primary Motor Cortex (2008)
  • Author(s): Masato Odagaki, Sanae Ohishi, Hiroshi Fukuda, Osamu Hiwaki
  • Journal Title: IEEE Transactions on Magnetics 44(11) Pages: 4445-4548
  • Peer Reviewed
• [Journal Article] Modification of Motor Evoked Potentials Caused by Electrical Peripheral Nerve Stimulation in Transcranial Magnetic Stimulation (2008)
  • Author(s): Osamu Hiwaki, Masato Odagaki, Hiroshi Fukuda, Atsushi Kodabashi, Toshiro Fujimoto
  • Journal Title: IEEE Transactions on Magnetics 44(11) Pages: 4440-44443
  • Peer Reviewed
• [Journal Article] Estimation Method on Multiple Sources of MEG Based on the Columnar Structure of the Cerebral Cortex (2008)
  • Author(s): Hiroshi Fukuda, Masato Odagaki, Osamu Hiwaki, Atsushi Kodabashi, Toshiro Fujimoto
  • Journal Title: IEEE Transactions on Magnetics 44(11) Pages: 4425-44431
  • Peer Reviewed
• [Journal Article] 両手指の連打タッピング運動における高密度脳電位計測 (2008)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Journal Title: 生体医工学 VOL. 46, NO. 6 Pages: 684-689
  • NAID: 110007098777
  • Peer Reviewed
• [Journal Article] Suppression of Electromyogram of Hand Muscle Elicited by Transcranial Magnetic Stimulation Over the Primary Motor Cortex (2008)
  • Author(s): Masato Odagaki, Sanae Ohishi, Hiroshi Fukuda, Osamu Hiwaki
  • Journal Title: IEEE TRANSACTIONS ON MAGNETICS VOL. 44, NO. 11 Pages: 4445-4548
  • Peer Reviewed
• [Journal Article] Modification of Motor Evoked Potentials Caused by Electrical Peripheral Nerve Stimulation in Transcranial Magnetic Stimulation (2008)
  • Author(s): Osamu Hiwaki, Masato Odagaki, Hiroshi Fukuda, Atsushi Kodabashi, Toshiro Fujimoto
  • Journal Title: IEEE TRANSACTIONS ON MAGNETICS VOL44, NO11 Pages: 4440-4543
  • Peer Reviewed
• [Journal Article] Estimation Method on Multiple Sources of MEG Based on the Columnar structure of the Cerebral Cortex (2008)
  • Author(s): Hiroshi Fukuda, Masato Odagaki, Osamu Hiwaki, Atsushi Kodabashi, Toshiro Fujimoto
  • Journal Title: IEEE TRANSACTIONS ON MAGNETICS VOL. 44, NO. 11 Pages: 4425-4431
  • Peer Reviewed
• [Presentation] 経頭蓋磁気刺激における刺激候補部位の選択による脳刺激部位推定の高速化 (2011)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京電機大学神田キャンパス
  • Year and Date: 2011-04-29
• [Presentation] Dynamics model of motor control system for finger movement accompanied by transcranial magnetic stimulation (2010)
  • Author(s): 樋脇治, 小田垣雅人, 福田浩士
  • Organizer: NEUROSCIENCE2010
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2010-11-13
• [Presentation] 手指の二点間到達運動についてのトルク変化最小モデルによるシミュレーション解析 (2010)
  • Author(s): 井盛健詞、福田浩士、小田垣雅人、樋脇治
  • Organizer: 第33回日本生体医工学会中国四国支部大会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-09-24
• [Presentation] 手指の二点間到達運動についてのトルク変化最小モデルによるシミュレーション解析 (2010)
  • Author(s): 井盛健詞, 福田浩士, 小田垣雅人, 樋脇治
  • Organizer: 第33回日本生体医工学会中国四国支部大会
  • Place of Presentation: 岡山大学大学院保健学研究科
  • Year and Date: 2010-09-24
• [Presentation] 手指の位置を保持するタスクにおける経頭蓋磁 気刺激の運動制御モデル (2010)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第25回生体・生理工学シンポジウム
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-09-23
• [Presentation] 手指の位置を保持するタスクにおける経頭蓋磁気刺激の運動制御モデル (2010)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第25回生体・生理工学シンポジウム
  • Place of Presentation: 岡山大学大学院保健学研究科
  • Year and Date: 2010-09-23
• [Presentation] Trajectory control model of finger movement after transcranial magnetic stimulation (2010)
  • Author(s): 樋脇治, 小田垣雅人, 福田浩士
  • Organizer: NEURO2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] Trajectory control model of finger movelnent after transcranial magnetic stimulation (2010)
  • Author(s): Osamu Hiwaki, Masato Odagaki, Hiroshi Fukuda
  • Organizer: NEURO2010(第33回日本神経科学大会)
  • Place of Presentation: 科戸コンベンションセンター
  • Year and Date: 2010-09-02
• [Presentation] 手指の位置を保持する運動制御システムにおけるTMSのダイナミクスモデル (2010)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第25回日本生体磁気学会大会
  • Place of Presentation: さわやかちば県民プラザ
  • Year and Date: 2010-07-29
• [Presentation] Stimulation study for voluntary movement of human thumb by minimum torque change model (2010)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Organizer: 第49回日本生体医工学会大会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2010-06-25
• [Presentation] Response of finger movement to transcranial magnetic stimulation in maintenance of constant finger force (2010)
  • Author(s): 小田垣雅人, 福田浩士, 樋脇治
  • Organizer: 第49回日本生体医工学会大会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2010-06-25
• [Presentation] Effect of transcranial magnetic stimulation on isotonic finger muscle contraction (2010)
  • Author(s): 小田垣雅人, 福田浩士, 樋脇治
  • Organizer: 11th Joint MMM-Intermag Conference 2010
  • Place of Presentation: Marriott Washington アメリカ合衆国
  • Year and Date: 2010-01-18
• [Presentation] Effect of transcranial magnetic stimulation on isotonic finger muscle contraction (2010)
  • Author(s): 小田垣雅人, 福田浩士, 樋脇治
  • Organizer: 11th Joint MMM-Intermag Conference 2010
  • Place of Presentation: Marriott Washington(アメリカ合衆国)
  • Year and Date: 2010-01-18
• [Presentation] 第一次運動野の経頭蓋磁気刺激に対する手指の等張性随意運動の応答 (2009)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第32回日本生体医工学会中国四国支部大会
  • Place of Presentation: 広島国際大学 国際教育センター
  • Year and Date: 2009-11-28
• [Presentation] 大脳皮質の錐体細胞の方向を考慮した最小ノルム法によるMEG電流現推定 (2009)
  • Author(s): 福田浩士、小田垣雅人、高田橋篤史、藤元登四郎、樋脇治
  • Organizer: 第32回日本生体医工学会中国四国支部大会
  • Place of Presentation: 広島国際大学 国際教育センター
  • Year and Date: 2009-11-28
• [Presentation] Change of continuous voluntary finger movement caused by transcranial magnetic stimulation of primary motor cortex (2009)
  • Author(s): 樋脇治, 小田垣雅人, 福田浩士
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-16
• [Presentation] 大脳皮質の構造に基づく神経興奮特性により推定した経頭蓋磁気刺激強度についての検討 (2009)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第24回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール
  • Year and Date: 2009-05-28
• [Presentation] ニューラルネットワークを用いた経頭蓋磁気刺激における運動誘発電位の判別分析 (2009)
  • Author(s): 福田浩士、小田垣雅人、樋脇治
  • Organizer: 第24回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール
  • Year and Date: 2009-05-28
• [Presentation] 手指の連続随意運動に対する第一次運動野の経頭蓋磁気刺激の効果 (2009)
  • Author(s): 樋脇治、小田垣雅人、福田浩士
  • Organizer: 第24回日本生体磁気学会大会
  • Place of Presentation: 金沢市文化ホール
  • Year and Date: 2009-05-28
• [Presentation] Precise Coil Positioning System Using Multi-articular Arm for Location of Stimulated Brain Area in Transcranial Magnetic Stimulation (2009)
  • Author(s): Masato Odagaki, Tomonori Inoue, Taro Ikeda, Hiroshi Fukuda, Osamu Hiwaki
  • Organizer: The 4th International IEEE EMBS Neural Engineering Conference
  • Place of Presentation: Sheraton at Antalyaトルコ
  • Year and Date: 2009-04-29
• [Presentation] A neural network for estimation of coil position in transcranial magnetic stimulation (2009)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Place of Presentation: Sheraton at Antalyaトルコ
  • Year and Date: 2009-04-29
• [Presentation] Effects of Transcranial Magnetic Stimulation on Voluntary Thumb Movement (2009)
  • Author(s): 樋脇治, 小田垣雅人, 福田浩士
  • Place of Presentation: Sheraton at Antalyaトルコ
  • Year and Date: 2009-04-29
• [Presentation] Effects of Transcranial Magnetic Stimulation on Voluntary Thumb Movement (2009)
  • Author(s): 樋脇治, 小田垣雅人, 福田浩士
  • Organizer: The 4th International IEEE EMBS Neural Engineering Conference
  • Place of Presentation: Sheraton at Antalya(トルコ)
  • Year and Date: 2009-04-29
• [Presentation] A neural network for estimation of coil position in transcranial magnetic stimulation (2009)
  • Author(s): 福田浩士, 小田垣雅人, 樋脇治
  • Organizer: The 4th International IEEE EMBS Neural Engineering Conference
  • Place of Presentation: Sheraton at Antalya(トルコ)
  • Year and Date: 2009-04-29
• [Presentation] Precise Coil Positioning System Using Multi-articular Arm for Location of Stimulated Brain Area in Transcranial Magnetic Stimulation (2009)
  • Author(s): Masato Odagaki, Tomonori Inoue, Taro Ikeda, Hiroshi Fukuda, Osamu Hiwaki
  • Organizer: The 4th International IEEE EMBS Neural Engineering Conference
  • Place of Presentation: Sheraton at Antalya(トルコ)
  • Year and Date: 2009-04-29
• [Presentation] 手指のピンチ動作における筋の最大随意収縮に対する経頭蓋磁気刺激の影響 (2009)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第48回日本生体医工学会大会
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2009-04-23
• [Presentation] 経頭蓋磁気刺激に誘発される筋活動と指力の解析 (2009)
  • Author(s): 福田浩士、堀泰基、小田垣雅人、樋脇治
  • Organizer: 第48回日本生体医工学会大会
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2009-04-23
• [Presentation] Study on sensory-motor interaction by measurement of SEFs and MEPs elicited with TMS and peripheral nerve stimulation (2008)
  • Author(s): Osamu Hiwaki, Masato Odagaki, Hiroshi Fukuda, Atsushi Kodabashi, Toshiro Fujimoto
  • Organizer: International Conference on Biomagnetism 2008
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2008-08-27
• [Presentation] Estimation method for MEG source distribution using spatial interpolation of magnetic sensors (2008)
  • Author(s): Hiroshi Fukuda, Masato Odagaki, Osamu Hiwaki, Atsushi Kodabashi, Toshiro Fujimoto
  • Organizer: International Conference on Biomagnetism 2008
  • Year and Date: 2008-08-27
• [Presentation] Effects of transcranial magnetic stimulation on hand electromyogram and finger trajectory (2008)
  • Author(s): 小田垣雅人, 大石沙苗, 福田浩士, 樋脇治
  • Organizer: International Conference on Biomagnetism 2008
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2008-08-27
• [Presentation] 経頭蓋磁気刺激の手指随意運動に対する抑制効果 (2008)
  • Author(s): 樋脇治、小田垣雅人、大石沙苗、福田浩士
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-11
• [Presentation] 体性感覚刺激と経頭蓋磁気刺激を用いた運動誘発電位計測と体性感覚誘発磁界計測による感覚運動連関についての検討 (2008)
  • Author(s): 樋脇治、小田垣雅人、福田浩士、高田橋篤史、藤元登四郎
  • Organizer: 第23回日本生体磁気学会大会
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2008-06-13
• [Presentation] 手指の筋電図および自発運動に対する経頭蓋磁気刺激の効果 (2008)
  • Author(s): 小田垣雅人、福田浩士、樋脇治
  • Organizer: 第23回日本生体磁気学会大会
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2008-06-12
• [Presentation] 大脳皮質の機能的円柱構造を反映したMEGの電流双極子分布推定法 (2008)
  • Author(s): 福田浩士、小田垣雅人、樋脇治、高田橋篤史、藤元登四郎
  • Organizer: 第23回日本生体磁気学会大会
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2008-06-12
• [Presentation] 大脳皮質一次運動野への経頭蓋磁気刺激が手指の随意運動に与える影響 (2008)
  • Author(s): 小田垣雅人、大石沙苗、福田浩士、樋脇治
  • Organizer: 第47回日本生体医工学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-05-10
• [Patent(Industrial Property Rights)] 脳機能解析装置 (2008)
  • Inventor(s): 樋脇治
  • Industrial Property Rights Holder: 広島市
  • Industrial Property Number: 2008-257509
  • Filing Date: 2008-10-02