Development of Nano Device to Detect Cellular Stress by Using Supercritical Coating method.
Project/Area Number |
20560707
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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Research Institution | Fukuoka University |
Principal Investigator |
MISHIMA Kenji Fukuoka University, 工学部, 准教授 (40190623)
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Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 薄膜・微粒子形成操作 / 医療工学 / 超臨界流体 |
Research Abstract |
In this work, we synthesized the peptides including an amino benzoic acid group as fluorescent probe in supercritical carbon dioxide in order to detect ACE inhibitor which reduces hypertension. The cellular stress detection was tried by using this synthesized fluorescent peptide. The effect of ACE inhibitor on the reduction of the cellular stress and blood vessel dilation was experimentally examined by means of cardiomyocyte. Furthermore, in order to search the hypertension control substances, separation and purification of target substances included in the soybean milk and the tofu (food related to the soybean) were carried out by using the synthesized fluorescent peptide.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Increment of Hypothalamic 2-Arachido-noylglycerol Induces the Preference for a High-fat Diet via Activation of Cannabinoid 1 Receptors2011
Author(s)
S.Higuchi, M.Ohji, M.Araki,R.Furuta, M.Katsuki, R.Yamaguchi, Y.Akitake, K.Matsuyama, K.Irie, K.Mishima, K.Mishima, K.Iwasaki, M.Fujiwara
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Journal Title
Behavioural Brain Research 216/1
Pages: 477-480
Related Report
Peer Reviewed
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[Journal Article] Measurement of Cerebral Blood Oxygenation during a Verbal Fluency Task with Juggling by Means of fNIRS2011
Author(s)
K.MISHIMA, K.IRIE, T.KATO, T.SUETSUGU, S.ARAMAK, T, H.TANAKA, Y.HIGAKI, S.HIGUCHI, Y.AKITAKE, K.MISHIMA, M.FUJIWARA
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Journal Title
Proceedings of IEEE Region 10 Conference(TENCON)2010
Related Report
Peer Reviewed
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[Journal Article] Increment of Hypothalamic 2-Arachidonoylglycerol Induces the Preference for a High-fat Diet via Activation of Cannabinoid 1 Receptors2011
Author(s)
S.HIGUCHI, M.OHJI, M.ARAKI, R.FURUTA, M.KATSUKI, R.YAMAGUCHI, Y.AKITAKE, K.MATSUYAMA, K.IRIE, K.MISHIMA, K.MISHIMA, K.IWASAKI, M.FUJIWARA
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Journal Title
Behavioural Brain Research
Volume: 216
Pages: 477-480
Related Report
Peer Reviewed
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[Journal Article] Reducing Acyl Migration during Purification of 2-Arachidonoylglycerol from Biological Samples before Gas Chromatography Mass Spectrometry Analysis2010
Author(s)
S.Higuchi, K.Irie, T.Nakano, Y.Sakamoto, Y.Akitake, M.Araki, M.Ohji, R.Furuta, M.Katsuki, R.Yamaguchi, K.Matsuyama, K.Mishima, K.Mishima, K.Iwasaki, M.Fujiwara
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Journal Title
Analytical Sciences 26/11
Pages: 1199-1202
NAID
Related Report
Peer Reviewed
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[Journal Article] Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion2010
Author(s)
M.Hazekawa, A.Kataoka, K.Hayakawa, T.Uchimasu, R.Furuta, K.Irie, Y.Akitake, M.yoshida, T.Fujioka, N.Egashira, R.Oishi, K.Mishima, K.Mishima, T. Uchida, K. Iwasaki, M.Fujiwara
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Journal Title
J.Health Science 56(3)
Pages: 296-303
NAID
Related Report
Peer Reviewed
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[Journal Article] マウスを用いた駆〓血丹参製剤の脳虚血性疾患に対する予防効果2010
Author(s)
榎木麻希子, 金子朋博, 入江圭一, 秋武義治, 早川和秀, 長戸麻実, 三島健一, 三島健司, 岡本拓也, 神村英利, 岩崎克典, 藤原道弘
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Journal Title
漢方と最新治療
Volume: 19
Pages: 251-258
Related Report
Peer Reviewed
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[Journal Article] Reducing Acyl Migration during Punfication of 2-Arachidonoylglycerol from Biological Samples before Gas Chromatography Mass Spectrometry Analysis2010
Author(s)
S.HIGUCHI, K.IRIE, T.NAKANO, Y.SAKAMOTO, Y.AKITAKE, M.ARAKI, M.OHJI, R.FURUTA, M.KATSUKI, R.YAMAGUCHI, K.MATSUYAMA, K.MISHIMA, K.MISHIMA, K.IWASAKI, M.FUJIWARA
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Journal Title
Analytical Sciences
Volume: 26
Pages: 1199-1202
Related Report
Peer Reviewed
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[Journal Article] The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice2010
Author(s)
Higuchi S, Irie K, Mishima S, Araki M, Ohji M, Shirakawa A, Akitake Y, Matsuyama K, Mishima K, Mishima K, Iwasaki K, Fujiwara M.
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Journal Title
J Pharmacol Sci. (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
吉田昌弘, 三島健司, 他29名
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Journal Title
若手研究者の大きな可能性を秘めた研究開発(化学工学会九州支部若手ケミカルエンジニア連絡会)
Pages: 17-23
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[Presentation] Challenge of Interdisciplinary and Integrated Education of Engineering, Medicine, Pharmacology, and Economics in Fukuoka University2009
Author(s)
K.Mishima, T.Kato, S.Aramaki, K.Irie, K.Mishima, M.Fujiwara, K.Tachibana, K.Saku, M.Abiru, K.Nishijima
Organizer
ITK-FUKUOKA2009
Place of Presentation
福岡大学
Year and Date
2009-11-07
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