• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Enhanced xylitol fermentation based on the activation of central metabolism caused by metabolic modification

Research Project

Project/Area Number 20560724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionKitami Institute of Technology

Principal Investigator

HORIUCHI Jun-ichi  Kitami Institute of Technology, 工学部, 教授 (30301980)

Co-Investigator(Renkei-kenkyūsha) TADA Kiyoshi  北見工業大学 (90333666)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsキシリトール / バイオマス / 代謝反応モデル / 最適化 / xylitol / Candida / Biorefinery / oxygen supply / optimization / Xylitol / Central metabolism / Fermentation / Biomass / 中枢代謝 / エネルギー代謝 / 酵母
Research Abstract

Microbial xylitol production from renewable resources is expected to have potentials to realize a cheaper production of xylitol with low environmental impact. In this study, in order to realize enhanced production of xylitol using Candida magnoliae from corn cobs, we developed a simplified metabolic reaction model concerning xylose metabolism. The metabolic flux analysis was successfully applied for effective production of xylitol and it can be a useful tool to obtain reliable information not only for genetic modification but also for operational improvements in microbial processes.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (20 results) Remarks (2 results)

  • [Journal Article] Hydrolysis of Sasa senanensis culm with dilute sulfuric acid for production of a fermentable substrate.2011

    • Author(s)
      M.Miura, A.Shimahata, T.Nishikawa, M.Aoyama, K.Tada, J.Horiuchi, M.Nakahara, C.Sakai
    • Journal Title

      J.Mater Cycles Waste Manag. 13

      Pages: 80-83

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hydrolysis of Sasa senanensis culm with dilute sulfuric acid for production of a fermentable substrate.2011

    • Author(s)
      M.Miura, A.Shimahata, T.Nishikawa, M.Aoyama, K.Tada, J.Horiuchi, M.Nakahara, C.Sakai
    • Journal Title

      J.Mater.Cycles Waste Manag.

      Volume: 13 Pages: 80-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biorefinery for bioethanol, lactic acid, xylitol and astaxanthin production from corn cobs2010

    • Author(s)
      J., Horiuchi, K.Tada, T.Kanno
    • Journal Title

      J.Biotechnol. 150, Suppl.1

      Pages: 171-171

    • Related Report
      2010 Final Research Report
  • [Journal Article] Biorefinery for bioethanol, lactic acid, xylitol and astaxanthin production from corn cobs2010

    • Author(s)
      J., Horiuchi, K.Tada, T.Kanno
    • Journal Title

      J.Biotechnol.

      Volume: 150 Pages: 171-171

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biorefinery for Effective Utilization of Agricultural Wastes2009

    • Author(s)
      J.Horiuchi, K.Tada
    • Journal Title

      J.Biosci.Bioeng. 108, Supplement 1

    • NAID

      210000003365

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prehydrolysis of xylan in culm of Sasa kurilensis with dilute sulfuric acid2009

    • Author(s)
      M.Miura, K.Yokono, H.Miyamoto, M.Aoyama, K.Tada, J.Horiuchi, Y.Kojima, C.Sakai, M.Nakahara
    • Journal Title

      European Journal of Wood and Wood Products, Published online

    • Related Report
      2010 Final Research Report
  • [Journal Article] Biorefinery for Effective Utilization of Agricultural Waste2009

    • Author(s)
      J.Horiuchi, K.Tada
    • Journal Title

      J.Biosci.Bioeng. 107

    • NAID

      210000003365

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioprocess Development for Microbial Xylitol Production from Agricultural Wastes2008

    • Author(s)
      J.Horiuchi, K.Tada
    • Journal Title

      J.Biotechnol. 136, Supplement 1

    • Related Report
      2010 Final Research Report
  • [Presentation] バイオマスを原料としたXanthophyllomyces dendrorhousによるキシリトール・アスタキサンチンの同時発酵生産2010

    • Author(s)
      鈴木由麻、多田清志、山内太、菅野亨、堀内淳一
    • Organizer
      第62回日本生物工学会大会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] バイオマスを原料としたXanthophyllomyces dendrorhousによるキシリトール・アスタキサンチンの同時醗酵生産2010

    • Author(s)
      鈴木由麻、多田清志、山内太、菅野亨、堀内淳一
    • Organizer
      第62回日本生物工学会大会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] エノキタケ廃培地を原料としたCandida magnoliaeによるキシリトール生産2010

    • Author(s)
      多田清志、原田陽、鈴木由麻、菅野亨、堀内淳一
    • Organizer
      化学工学会第42回秋季大会
    • Place of Presentation
      同志社大学
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] バイオリファイナリー:北海道産トウキビの芯からエタノール、乳酸、キシリトール、アスタキサンチンを作る2010

    • Author(s)
      堀内淳一
    • Organizer
      平成22年度日本生物工学会シンポジウム
    • Place of Presentation
      北見工業大学
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] コーンコブを原料としたキシリトール発酵の酸素供給制御2010

    • Author(s)
      多田清志、高村裕哉、水尻直樹、菅野亨、堀内淳一
    • Organizer
      平成22年度日本生物工学会シンポジウム
    • Place of Presentation
      北見工業大学
    • Year and Date
      2010-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] バイオリファイナリー:北海道産トウキビの芯からエタノール、乳酸、キシリトール、アスタキサンチンを作る2010

    • Author(s)
      堀内淳一
    • Organizer
      日本生物工学会シンポジウム
    • Place of Presentation
      北見工業大学
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] コーンコブを原料としたXanthophyllomyces dendrorhousによるキシリトール・アスタキサンチンの同時醗酵生産2010

    • Author(s)
      鈴木由麻、多田清志、山内太、菅野亨、堀内淳一
    • Organizer
      日本生物工学会シンポジウム
    • Place of Presentation
      北見工業大学
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] コーンコブを原料としたキシリトール醗酵の酸素供給制御2010

    • Author(s)
      多田清志、高村裕哉、水尻直樹、菅野亨、堀内淳一
    • Organizer
      日本生物工学会シンポジウム
    • Place of Presentation
      北見工業大学
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of metabolic flux analysis for optimization and control of microbial xylitol production from biomass2010

    • Author(s)
      J.Horiuchi, K.Tada
    • Organizer
      Metabolic Engineering Conference IIIV
    • Place of Presentation
      韓国・済州島
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of metabolic flux analysis for optimization and control of microbial xylitol production from biomass2010

    • Author(s)
      堀内淳一, 多田清志
    • Organizer
      Proceeding of Metabolic Engineering Conference IIIV
    • Place of Presentation
      Ceju, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] コーンコブを原料したバイオリファイナリーの構築2010

    • Author(s)
      堀内淳一、多田清志, 他
    • Organizer
      化学工学会年会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2010 Final Research Report
  • [Presentation] 寒冷地バイオ資源を活用したバイオリファイナリー2010

    • Author(s)
      堀内淳一
    • Organizer
      北見市汚泥利用協議会
    • Place of Presentation
      北見市
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 寒冷地バイオ資源を活用したバイオリファイナリー2010

    • Author(s)
      堀内淳一
    • Organizer
      CREST公開シンポジウム
    • Place of Presentation
      北見工業大学
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] コーンコブを原料としたバイオリファイナリーの構築2010

    • Author(s)
      堀内淳一, 他
    • Organizer
      化学工学会年会
    • Place of Presentation
      鹿児島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Biorefinery Based on Cascade Utilization of Agricultural Wastes2009

    • Author(s)
      堀内淳一, 多田清志
    • Organizer
      Proc.of YABEC2009
    • Place of Presentation
      Xiamen, China
    • Related Report
      2010 Final Research Report
  • [Presentation] 寒冷地バイオ資源を活用したバイオリファイナリー(第2報キシリトール生産)2009

    • Author(s)
      堀内淳一、多田清志, 他
    • Organizer
      化学工学会第41回秋季大会
    • Place of Presentation
      広島大学
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 寒冷地バイオ資源を活用したバイオリファイナリーの構築2009

    • Author(s)
      堀内淳一、多田清志, 他
    • Organizer
      日本生物工学会大会
    • Place of Presentation
      名古屋大学
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 寒冷地バイオ資源を活用したバイオリファイナリー2009

    • Author(s)
      堀内淳一
    • Organizer
      東農大オホーツク実学センター公開シンポジウム
    • Place of Presentation
      東京農業大学
    • Related Report
      2010 Final Research Report
  • [Presentation] 寒冷地バイオ資源を活用したバイオリファイナリー2009

    • Author(s)
      堀内淳一
    • Organizer
      東農大学オホーツク実学センター公開シンポジウム
    • Place of Presentation
      東京農業大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bioprocess Development for Microbial Xylitol Production from Agricultural Wastes2008

    • Author(s)
      J. Horiuchi and K. Tada.
    • Organizer
      International-Symvosium on Biotechnology 2008
    • Place of Presentation
      Dalian, China
    • Year and Date
      2008-10-16
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://bioprocess-eng.com/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi