Enhanced xylitol fermentation based on the activation of central metabolism caused by metabolic modification
| Project/Area Number |
20560724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kitami Institute of Technology |
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Principal Investigator |
HORIUCHI Jun-ichi Kitami Institute of Technology, 工学部, 教授 (30301980)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Kiyoshi 北見工業大学 (90333666)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | キシリトール / バイオマス / 代謝反応モデル / 最適化 / xylitol / Candida / Biorefinery / oxygen supply / optimization / Xylitol / Central metabolism / Fermentation / Biomass / 中枢代謝 / エネルギー代謝 / 酵母 |
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| Research Abstract |
Microbial xylitol production from renewable resources is expected to have potentials to realize a cheaper production of xylitol with low environmental impact. In this study, in order to realize enhanced production of xylitol using Candida magnoliae from corn cobs, we developed a simplified metabolic reaction model concerning xylose metabolism. The metabolic flux analysis was successfully applied for effective production of xylitol and it can be a useful tool to obtain reliable information not only for genetic modification but also for operational improvements in microbial processes.
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Report
(4 results)
Research Products
(30 results)
