| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The chiral alcohol production from ketone catalyzed by immobilized ketoreductases (alcohol dehydrogenases) has been investigated in a gas-solid bioreactor. As fundamental design of continuous reaction process, the conditions for immobilized enzyme preparation as functions of the reduced pressure degree, the buffer pH as well as the buffer concentration and for reaction as functions of the water concentration and the temperature were optimized. Also, the optimal reaction systems and enzyme sources for the gas phase reaction were investigated.
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