| Project/Area Number |
20570055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
|
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| Research Institution | Shizuoka University |
|---|
Principal Investigator |
SUZUKI Masakazu Shizuoka University, 理学部, 准教授 (60280913)
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| Co-Investigator(Renkei-kenkyūsha) |
NARUSE Kiyoshi 基礎生物学研究所, バイオリソース研究室, 准教授 (50208089)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アクアポリン / 無尾両生類 / バソトシン / 水吸収 / 進化 / 遺伝子 / アマガエル / AQP / 水水吸収 |
|---|
| Research Abstract |
Although more genomic data are needed, it is suggested that a duplicated AQP0 might be the ancestor gene for AQP2, AQP5, and AQPa2. A current scenario is that AQP0 had arisen early in vertebrate evolution, and a gene duplication event then generated a AQP0 paralogue, prior to the divergence of the actinopterygian lineage and sarcopterygian lineage giving rise to tetrapods. Before the emergence of anuran amphibians, the AQP0 paralogue evolved to kidney-type AQP2 and AQP5, undergoing a tandem gene duplication. The resultant FAIM2-(AQP2, AQP5)-RACGAP1 gene linkage was basically inherited to contemporary tetrapods (Ensembl). Within the amphibian lineage to anurans, kidney-type AQP2 further underwent local gene duplications between FAIM2 and RACGAP1, leading to the occurrence of ventral skin-type and urinary bladder-type AQPa2 genes.
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