| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In the amphibian digestive tract, thyroid hormone(TH) induces stem cells that generate the adult epithelium similar to the mammalian counterpart. In the present study, to clarify molecular mechanisms regulating the stem cells, we performed tissue recombinant culture experiments, using the small intestine of transgenic Xenopus laevis tadpoles. Our results indicate that both TH response genes expressed in the epithelium and those in the connective tissue are necessary for the larval epithelium to dedifferentiate into the adult stem cells. In addition, expression analyses of TH response genes suggest important roles of Shh and Wnt signaling pathways in establishment of the stem cell niche.
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