| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Estrogens are necessary for ovarian differentiation in most vertebrates including human. Estrogen actions are largely mediated through the estrogen receptors (ERs), which are hormone activated transcription factors. To understand the molecular evolution of ER, we tried to isolate cDNAs encoding ERs from amphioxus, ancient fishes, and other species. We found that amphioxus that is an invertebrate has already possessed the ER gene. Our functional analyses suggest that the function of ER as a hormone-dependent transcription factor might be gained through the evolutionary process.
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