Investigation of a tachykininergic proteases-associated oocyte growth
Project/Area Number |
20570077
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
|
Research Institution | Suntory Institute for Bioorganic Research |
Principal Investigator |
SATAKE Honoo Suntory Institute for Bioorganic Research, 分子生物学研究部, 主幹研究員 (20280688)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | タキキニン / カタユウレイボヤ / 卵細胞 / プロテアーゼ / 哺乳類 / 成長機構 / 卵巣 |
Research Abstract |
We have substantiated that a neuropeptide, tachykinin, up-regulates growth of vitellogenic oocytes via the activation of proteases such as cathepsin D, carboxypeptidase, and chymotrypsin. Mooreover, this novel oocyte growth pathway has been shown to be suppressed by another neuropeptide, neurotensin. We have also revealed that the protease-associated oocyte growth is essentially conserved in mice.
|
Report
(4 results)
Research Products
(79 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Calcitonin in a protochordate, Ciona intestinalis : the prototype of the vertebrate Calcitonin/Calcitonin gene related peptide family2009
Author(s)
Sekiguchi T., Suzuki N., Fujiwara N., Aoyama M., Kawada M., Sugase K., Murata Y., Sasayama Y., Ogasawara M., Satake H.
-
Journal Title
FEBS J. 276(16)
Pages: 4437-4447
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Neuropeptides and hormone peptides in Ciona intestinalis2009
Author(s)
Satake, Kawada, Aoyama, Sekiguchi, Fujie, Okada, Hotta, Sakai, Oka, Ogasawara, Satoh
Organizer
The 5th International Tunicate meeting
Place of Presentation
Okinawa
Year and Date
2009-06-24
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Handbook of Oxytocin Research : Synthesis, Storage and Release, Actions, and Drug Forms2009
Author(s)
Kawada, T., Sekiguchi, T., Sakai, T., Aoyama, M., Satake, H.
Total Pages
308
Publisher
Nova Science Publishers, Inc., Hauppauge, NY
Related Report
-
-
-
-
-