| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We have substantiated that a neuropeptide, tachykinin, up-regulates growth of vitellogenic oocytes via the activation of proteases such as cathepsin D, carboxypeptidase, and chymotrypsin. Mooreover, this novel oocyte growth pathway has been shown to be suppressed by another neuropeptide, neurotensin. We have also revealed that the protease-associated oocyte growth is essentially conserved in mice.
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