| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The purpose of this project is to clarify the mechanism of the redoxand CO-dependent transcription by NPAS2. By using resonance Raman technique, we found that CO can bind to heme located inside NPAS2, which leads to a small conformational change around heme peripheral groups. Such a conformational change around heme is a trigger for the protein whole structural change to modulate the affinity of NPAS2 to the target DNA.
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