| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
A remarkable difference was observed in the liver pathology as a result of giving the calorie-rich food that caused the metabolic syndrome by using GM3 synthesis enzyme (GM3S) deficient mouse. As for a reaction of an immunity system cell, the increase of IL-6 was observed. Moreover, an increase in the amount of the cytokine under the LPS stimulation was observed in mouse embryo fibroblast (MEF) derived from GM3 knockout mouse. As for central nerve system, GM3 knockout mice showed the loss of function by behavior test. An amount of glycoprotein increased in the GM3 knockout mice.
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