Study for degradation mechanism of a cell cycle regulator induced by Stress-activated MAP kinases
| Project/Area Number |
20570126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
UCHIDA Sanae Kanazawa University, イノベーション創成センター, 博士研究員 (50464045)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Katsumi 金沢大学, 薬学系, 准教授 (10191280)
KUDO Yasusei 広島大学, 医歯(薬)学総合研究科, 助教 (50314753)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ストレス / シグナル伝達 / 細胞周期 / 蛋白分解 / 蛋白質分解 |
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| Research Abstract |
We previously found that non-genotoxic stress, whose primary target is not genomic DNA, induced cell cycle arrest through the degradation of Cdc25A and Cdc25B. In this study, we discovered that Cdc25B was degraded through the ubiquitylation by SCF^<βTrCP> induced by the phosphorylation of Ser101/103 by stress-activated MAP kinases.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Stress-activated mitogen-activated protein kinase c-Jun NH_2-terminal kinase and p38 target Cdc25B for degradation.2009
Author(s)
Uchida, S., Yoshioka, K., Kizu, R., Nakagama, H., Matsunaga, T., Ishizaka, Y., Poon, R., Y., Yamashita, K.
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Journal Title
Cancer Research 69
Pages: 6438-6444
Related Report
Peer Reviewed
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[Journal Article] The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF^<βTrCP>-dependent degradation for cell cycle arrest.2009
Author(s)
Isoda, M., Kanemori, Y., Nakajo, N., Uchida, S., Yamashita, K., Ueno, H., Sagata, N.
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Journal Title
Molecular and Cellular Biology 20
Pages: 2186-2195
Related Report
Peer Reviewed
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