Molecular analysis of iron -sulfur cluster biosynthesis machinery : Reaction mechanism based on conformational transition of IscU
| Project/Area Number |
20570130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Saitama University |
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Principal Investigator |
TAKAHASHI Yasuhiro Saitama University, 理工学研究科, 教授 (10154874)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUYAMA Keiichi 大阪大学, 理学研究科, 教授 (80032283)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 鉄硫黄タンパク質 / 鉄硫黄クラスター / 生合成 / 遺伝子 / タンパク質 |
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| Research Abstract |
Proteins containing Fe-S clusters are called Fe-S proteins and participate in a wide range of cellular processes from energy metabolism to gene regulation. The assembly of Fe-S clusters is achieved by a multicomponent machinery. In this study, we have characterized the IscU protein that plays a central role in the biosynthesis machinery and revealed its functionality based on the unique structure.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Molecular Dynamism of Fe-S Cluster Biosynthesis Implicated by the Structure of SufC2-SufD2 Complex2009
Author(s)
Kei Wada, Norika Sumi, Rina Nagai, Kenji Iwasaki, Takayuki Sato, Kei Suzuki, Yuko Hasegawa, Shintaro Kitaoka, Yoshiko Minami, F.Wayne Outten, Yasuhiro Takahashi, Keiichi Fukuyama
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Journal Title
J.Mol.Biol. 387
Pages: 245-258
Related Report
Peer Reviewed
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[Presentation] Crystal Structure of the SufC_2-SufD_2 Complex : Implications for Dynamic Rearrangement During Fe-S cluster Biosynthesis2009
Author(s)
Kei Wada, Norika Sumi, Rina Nagai, Kenji Iwasaki, Takayuki Sato, Kei Suzuki, Yuta Nagasaka, Yoshiko Minami, F.Wayne Outten, Yasuhiro Takahashi, Keiichi Fukuyama
Organizer
Fifth International Conference on Iron-Sulfur Cluster Biogenesis and Regulation.
Place of Presentation
Georgia, USA
Year and Date
2009-08-31
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