Modulation of interferon action by intrinsic galectin-9 in cultured human endothelial cells.
| Project/Area Number |
20570133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
NISHI Nozomu Kagawa University, 総合生命科学研究センター, 准教授 (10145047)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ガレクチン / 血管内皮細胞 / インターフェロン / ケモカイン / RNA干渉 |
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| Research Abstract |
Knockdown experiments using siRNA of galectin-9 suggested that intrinsic galectin-9 modulates IFN action in cultured human endothelial cells. Confirmation experiments using new-generation siRNAs, however, demonstrated that the observation was due to the off-target effects of old-generation siRNAs. The experiments carried out on the last year suggested the relationship between galectin-9 and endoplasmic reticulum stress (ER stress) in human endothelial cells. I am continuing to investigate the role of galectin-9 in endothelial cells in relation to ER stress.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Involvement of Galectin-9 in Lung Eosinophilia in Patients with Eosinophilic Pneumonia.2010
Author(s)
Katoh S, Nobumoto A, Matsumoto N, Matsumoto K, Ehara N, Niki T, Inada H, Nishi N, Yamauchi A, Fukushima K, Hirashima M.
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Journal Title
Int Arch Allergy Immunol 153
Pages: 294-302
Related Report
Peer Reviewed
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[Journal Article] Tim-3/Galectin-9 Pathway : Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells.2010
Author(s)
Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK.
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Journal Title
J Immunol 185
Pages: 1383-1392
Related Report
Peer Reviewed
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[Journal Article] Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.2009
Author(s)
Nobumoto A, Oomizu S, Arikawa T, Katoh S, Nagahara K, Miyake M, Nishi N, Takeshita K, Niki T, Yamauchi A, Hirashima M.
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Journal Title
Clin Immunol 130
Pages: 322-330
Related Report
Peer Reviewed
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[Journal Article] Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.2008
Author(s)
Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M.
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Journal Title
Clin Immunol 127
Pages: 78-88
Related Report
Peer Reviewed
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[Presentation] CREST国際シンポジウム「獲得免疫と糖鎖生物学」2009
Author(s)
Jun Iwaki, Hiroaki Tateno, Sachiko Nakamura-Tsuruta, Noboru Uchiyama, Nozomu Nishi, Toshikazu Minamisawa, Junko Kominami, Takanori Nakamura, Jun Hirabayashi
Organizer
Frontal affinity chromatography reveals a common binding rule for galectins
Place of Presentation
かずさアカデミアホール(千葉県)国立京都国際会館(京都府)
Year and Date
2009-03-23
Related Report
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