| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Knockdown experiments using siRNA of galectin-9 suggested that intrinsic galectin-9 modulates IFN action in cultured human endothelial cells. Confirmation experiments using new-generation siRNAs, however, demonstrated that the observation was due to the off-target effects of old-generation siRNAs. The experiments carried out on the last year suggested the relationship between galectin-9 and endoplasmic reticulum stress (ER stress) in human endothelial cells. I am continuing to investigate the role of galectin-9 in endothelial cells in relation to ER stress.
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